Active Recombinant Human IL29 Protein
|Product Overview :||Human IL29 (Q8IU54 , 24 a.a. - 200 a.a.) partial recombinant protein expressed in Escherichia coli.|
- Gene Information
- Related Products
|Description :||This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq|
|Source :||E. coli|
|Bio-activity :||The ED50 is determined in an anti-viral assay using human HepG2 cells infected with EMCV is typically 1-5 ng/mL.|
|Molecular Mass :||20 kDa|
|AA Sequence :||TSKPTTTGKGCHIGRFKSLSPQELA SFKKARDALEESLKLKNWSCSSPVF PGNWDLRLLQVRERPVALEAELALT LKVLEAAAGPALEDVLDQPLHTLHH ILSQLQACIQPQPTAGPRPRGRLHH WLHRLQEAPKKESAGCLEASVTFNL FRLLTRDLKYVADGNLCLRTSTHPE ST|
|Endotoxin :||< 0.1 ng/μg (1 EU/μg)|
|Purity :||> 90% by SDS-PAGE and HPLC|
|Applications :||Functional Study
|Storage :||Store at -20 centigrade on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4 centigrade for 1 month or store at -20 centigrade for 6 months. Aliquot to avoid repeated freezing and thawing.|
|Storage Buffer :||Lyophilized from 20 mM PB, 130 mM NaCl, pH 7.5|
|Gene Name :||IL29 interleukin 29 (interferon, lambda 1) [ Homo sapiens ]|
|Official Symbol :||IL29|
|Synonyms :||IL29; interleukin 29 (interferon, lambda 1); interleukin 29; interleukin-29; IFNL1; IL 29; IFN-lambda-1; cytokine Zcyto21; interferon lambda-1; interferon-lambda-1; interferon, lambda 1; IL-29;|
|Gene ID :||282618|
|mRNA Refseq :||NM_172140|
|Protein Refseq :||NP_742152|
|UniProt ID :||Q8IU54|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
The dose of IL29 should be determined according to the specific disease and patient situation, and the most appropriate dose usually needs to be determined through clinical trials and individualized treatment.
IL29 and IL28 are two similar interferons that are similar in structure and function, but with some minor differences such as receptor affinity and signaling pathways.
IL29 is highly targeted and safe, and can stimulate the response of the own immune system, which has better therapeutic effect and fewer side effects than traditional drugs.
At present, there are no clear studies to prove that IL29 has a direct antioxidant effect, but it may indirectly affect oxidative stress response by regulating immune system function.
IL29 has potential in the treatment of rheumatoid arthritis, hepatitis B, psoriasis and other autoimmune diseases.
It may cause some mild side effects, such as fever, fatigue, headache, etc., but it is generally reversible, and serious side effects are rare.
Customer Reviews (3)Write a review
Detect whether recombinant IL-29 protein causes immune responses, including allergic reactions, to avoid potential safety concerns. -
The biological activity of recombinant IL-29 protein was verified by cell experiments, including its effects on target cells, such as inhibiting viral proliferation and enhancing immune response. At the same time, to understand its interaction with relevant signaling pathways, to further evaluate its efficacy. -
It has the function of inhibiting virus proliferation and enhancing immune response. -
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