il7r
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  • Official Full Name
  • IL7R interleukin 7 receptor
  • Background
  • CD127 is a 60-90 kD type I transmembrane glycoprotein, also known as IL-7 receptor alpha chain or IL-7Ralpha. It forms heterodimer with the common gamma chain (gammac or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.
  • Synonyms
  • IL7R; interleukin 7 receptor; interleukin-7 receptor subunit alpha; CD127; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; ILRA; IL7RA; CDW127; IL-7R-alpha;
Cat.#:IL7R-2179HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL7R Protein, MYC/DDK-tagged
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Cat.#:IL7R-5168HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL7R Protein, GST-tagged
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Cat.#:IL7R-5169HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL7R Protein
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Cat.#:IL7R-129HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 7 Receptor, Fc Chimera
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Cat.#:IL7R-130HTag:Fc/Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL7R Protein, Fc & Avi-tagged, Biotinylated
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Cat.#:IL7R-1951HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL7R protein, His & GST-tagged
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Cat.#:IL7R-2260HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL7R, His tagged
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Cat.#:IL7R-29272THTag:
Source (Host):Species:Human
Product nameRecombinant Human IL7R
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Cat.#:IL7R-301HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Interleukin 7 Receptor, MIgG2a Fc-tagged
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Cat.#:IL7R-302HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Interleukin 7 Receptor, HIgG1 Fc-tagged
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Cat.#:IL7R-788HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL7R, Fc-His tagged
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Cat.#:IL7R-951HTag:Fc/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human IL7R Protein, Fc/His-tagged
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Cat.#:Il7r-1758MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Interleukin 7 Receptor
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Cat.#:Il7r-1952MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il7r protein, His-tagged
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Cat.#:Il7r-3272MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il7r, His tagged
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Cat.#:Il7r-1953RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il7r protein, His & T7-tagged
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Cat.#:IL7R-291RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il7r, His tagged
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Cat.#:Il7r-679RTag:Fc Chimera
Source (Host):NSO cellsSpecies:Rat
Product nameRecombinant Rat Il7r, Fc Chimera
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Cat.#:Il7r-8711RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il7r, Fc tagged
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Cat.#:IL7R-1231CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL7R Protein, His-tagged
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Cat.#:IL7R-621CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL7R Protein, His-tagged
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Cat.#:IL7R-3603CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL7R
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Cat.#:IL7R-6306ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL7R
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Cat.#:IL7R-2595HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL7R cell lysate
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Cat.#:IL7R-2473MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL7R cell lysate
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Cat.#:IL7R-959RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat IL7R cell lysate
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Involved Pathway

IL7R involved in several pathways and played different roles in them. We selected most pathways IL7R participated on our site, such as Cytokine-cytokine receptor interaction, FoxO signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL7R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TNFRSF11B; CXCL6; VEGFA; TNFRSF14; CCR1; CCL27B; IL7; TNFRSF10A; EDAR; IL12BA
FoxO signaling pathway
AKT2; PLK1; CAT; MAPK12A; FBXO32; PRKAB2; BNIP3; FOXO6; PDPK1; GRB2A
PIK-Akt signaling pathway
TNR; CREB5; IFNA2; PDGFD; CREB3L1; MET; PPP2R1A; IFNA5; ITGA7; INS1
Jak-STAT signaling pathway
SOCS3; Il23a; Il12b; OSM; JAK2B; CCND2; M17; MYCB; IL13; IL7R; IL10RA
Hematopoietic cell lineage
CD1D2; CD2; CSF1R; FLT3LG; HLA-DRB3; CSF1; CD1B; TFRC; HLA-DRB1; ITGA2B
Primary i
ORAI1; RAG1; CD40; RFXAP; CD8B1; AIRE; PTPRC; CD40LG; CD8A; IL2RG
nodeficiency
TAP2; RFX5; IGLL1; CD3D; PTPRC; BLNK; CD8A; CD4; CD40LG; ICOS

Protein Function

IL7R has several biochemical functions, for example, antigen binding, interleukin-7 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL7R itself. We selected most functions IL7R had, and list some proteins which have the same functions with IL7R. You can find most of the proteins on our site.
Function
Related Protein
Function antigen binding
Related Protein IGJ; TGFB1; Ighg2a; HNRNPM; PPP2R1A; LILRA3; LILRA2; SPON2; IGHM; MHC1UKA
Function interleukin-7 receptor activity
Related Protein IL7R
Function protein binding
Related Protein HINFP; AKT3; LRFN2; PIPOX; KTI12; ASF1B; BCL11B; FGFR4; PRDM1; GTF3C6

Interacting Protein

IL7R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL7R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL7R.
IL7; IL2RG; hmwC

IL7R Related Articles

Bayer, DK; Martinez, CA; et al. Vaccine-associated varicella and rubella infections in severe combined immunodeficiency with isolated CD4 lymphocytopenia and mutations in IL7R detected by tandem whole exome sequencing and chromosomal microarray. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:459-469(2014).
Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).