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Recombinant Mouse Interleukin 7 Receptor

Cat.No. : Il7r-1758M
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  • Gene Information
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Cat. No. : Il7r-1758M
Description : IL-7 receptor alpha (IL-7Ra), also known as CD127, is expressed on bone marrow lymphoid precursors, pro-B cells, monocytes/macrophages, natural killer (NK) cells, naïve T cells and memory CD4+ and CD8+ T cells. IL-7Ra is also expressed on non-immune somatic cells such as intestinal colorectal and renal carcinoma cell lines and keratinocytes. IL-7Ralpha displays a synergistic decrease in the number of T-cell, NK-cell and multipotent progenitors in the thymus, indicating that these distinct survival pathways converge to promote the development of multipotent lymphoid progenitors.
Molecular Weight : The predicted molecular weight of Recombinant Mouse IL-7 Rα is Mr 51.6 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55-60 kDa.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >90% by SDS Page and analyzed by silver stain..
Endotoxin : <0.1 ng per 1 µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : Il7r interleukin 7 receptor [ Mus musculus ]
Synonyms : Il7r; interleukin 7 receptor; CD127; MGC107557; IL-7Ralpha; 15 A1; IL-7 receptor alpha chain; interleukin 7 receptor alpha chain
Gene ID : 16197
mRNA Refseq : NM_008372
Protein Refseq : NP_032398
UniProt ID : P16872
Chromosome Location : 15 4.6 cM
Pathway : Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway; Primary immunodeficiency
Function : cytokine receptor activity; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the prospect of recombinant IL7R in tumor immunotherapy? 11/19/2022

IL7R is a potential drug for tumor immunotherapy, which is expected to enhance anti-tumor immune response, but further research and clinical demonstration are still needed.

Is there any research showing that recombinant IL7R can be used to treat immune system failure? 09/23/2022

Recombinant IL7R can enhance the body's immune response, but there is not enough evidence to show that it can be used to treat immune system failure.

How the role of IL7R in immunotherapy? 05/05/2022

It can enhance the immune response ability of T cells and improve the immune response of the body, so as to have a therapeutic effect on immune-related diseases.

Does IL7R have synergistic effects with immune checkpoint inhibitors? 04/20/2022

There is no clear evidence that IL7R has a synergistic effect with immune checkpoint inhibitors, but this research direction deserves further exploration.

Which diseases is IL7R associated with? 08/03/2020

IL7R has been associated with immune-related diseases such as cancer, inflammatory bowel disease, and rheumatoid arthritis.

Is there any restriction on the use of IL7R? 10/13/2019

The use of IL7R is patient specific and may be subject to some limitations, such as pregnant and lactating women and patients with certain immune-related diseases.

Customer Reviews (3)

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Reviews
02/21/2022

    The pharmacodynamic parameters of IL7R were good.

    02/01/2022

      IL7R has good compatibility and stability with various excipients.

      09/30/2021

        Strong potential to desensitize specific allergens.

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