Recombinant Full Length Human IL7R Protein, C-Flag-tagged

• Cat.No.: IL7R-1471HFL
• Product Overview: Recombinant Full Length Human IL7R Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 49.4 kDa
• AA Sequence: MTILGTTFGMVFSLLQVVSGESGYA QNGDLEDAELDDYSFSCYSQLEVNG SQHSLTCAFEDPDVNITNLE FEICGALVEVKCLNFRKLQEIYFIE TKKFLLIGKSNICVKVGEKSLTCKK IDLTTIVKPEAPFDLSVIYR EGANDFVVTFNTSHLQKKYVKVLMH DVAYRQEKDENKWTHVNLSSTKLTL LQRKLQPAAMYEIKVRSIPD HYFKGFWSEWSPSYYFRTPEINNSS GEMDPILLTISILSFFSVALLVILA CVLWKKRIKPIVWPSLPDHK KTLEHLCKKPRKNLNVSFNPESFLD CQIHRVDDIQARDEVEGFLQDTFPQ QLEESEKQRLGGDVQSPNCP SEDVVITPESFGRDSSLTCLAGNVS ACDAPILSPSRSLDCRESGKNGPHV YQDLLLSLGTTNSTLPPPFS
  LQSGILTLNPVAQGQPILTSLGSNQ EEAYVTMSSFYQNQTRTRPLEQKLI SEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway, Primary immunodeficiency

Gene Information

• Gene Name: IL7R interleukin 7 receptor [ Homo sapiens (human) ]
• Official Symbol: IL7R
• Synonyms: ILRA; CD127; IL7RA; CDW127; IMD104; lnc-IL7R; IL-7R-alpha
• Gene ID: 3575
• mRNA Refseq: NM_002185.5
• Protein Refseq: NP_002176.2
• MIM: 146661
• UniProt ID: P16871