ilk
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  • Official Full Name
  • integrin-linked kinase
  • Background
  • Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • ILK; integrin-linked kinase; integrin-linked protein kinase; ILK-1; p59ILK; integrin-linked kinase-2; 59 kDa serine/threonine-protein kinase; P59; ILK-2; DKFZp686F1765
Cat.#:ILK-1179HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ILK Protein (1-228 aa), His-tagged
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Cat.#:ILK-5158HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ILK Protein, GST-tagged
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Cat.#:ILK-12HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ILK, MYC/DDK-tagged
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Cat.#:ILK-8187MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ILK Protein
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Cat.#:ILK-3052RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ILK Protein
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Cat.#:ILK-2259RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ILK Protein, His-tagged
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Cat.#:ILK-5768CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ILK
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Cat.#:ILK-10850ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ILK
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Cat.#:ILK-904HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Integrin-Linked Kinase, His-tagged
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Cat.#:ILK-5219HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ILK 293 Cell Lysate
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Cat.#:ILK-5220HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ILK 293 Cell Lysate
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Involved Pathway

ILK involved in several pathways and played different roles in them. We selected most pathways ILK participated on our site, such as PPAR signaling pathway, Focal adhesion, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ILK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
FABP1A; ACSBG1; ACSL3A; ACSL1; APOA5; CYP27A1; MMP1A; SLC27A1A; ACADL; PPARAB
Focal adhesion
IGF1R; BADB; PAK2A; PAK7; GSK3AA; ARHGAP35; RAP1A; RHOAA; RAC3; SRC
Bacterial invasion of epithelial cells
FN1; DOCK1; DNM3; SHC4; CLTC; WASL; ITGB1; VCL; RHOA; CLTA
Endometrial cancer
PIK3CB; TCF7L2; TP53; PIK3R2; CDH1; CASP9; MAPK3; AXIN1; PIK3R1; HRAS

Protein Function

ILK has several biochemical functions, for example, ATP binding, SH3 domain binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ILK itself. We selected most functions ILK had, and list some proteins which have the same functions with ILK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PCCB; KIAA1804; DYRK1AA; PASK; HELQ; SMC1A; EPHA2A; ABCB9; CDK9; CDK7
Function SH3 domain binding
Related Protein ARHGAP27; CYBA; CD3E; ELMO3; KHDRBS1; NCF1; VASP; LANCL1; EVLB; OSTF1
Function integrin binding
Related Protein CXADR; ADAM22; TGFBI; EDIL3; FN1; ITGB5; ICAM3; PPAP2B; P4HB; ACTN2
Function protein binding
Related Protein MITD1; RBM12B; C10orf33; TTC30B; APOE; GPSM3; LIN28B; GPR177; NEURL1B; NIPSNAP3A
Function protein kinase binding
Related Protein VRK1; PPP1R12A; SPRY2; CD226; CCND3; ZFP36; DUSP3; MAP3K5; LCK; LIPE
Function protein serine/threonine kinase activity
Related Protein NLK1; ERN1; RIOK2; CSNK1G2; PBK; PRKAA2; CLK3; MAPK11; GSK3A; LATS2
Function signal transducer activity
Related Protein FLNA; LGALS9; GNAI2A; BST2; GNAQ; MIER1B; DKK1; LITAF; TAAR10D; EEF1D

Interacting Protein

ILK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ILK here. Most of them are supplied by our site. Hope this information will be useful for your research of ILK.
PARVA; LIMS1

ILK Related Articles

Li, T; Zhu, Y; et al. RHO KINASE ACTS AS A DOWNSTREAM MOLECULE TO PARTICIPATE IN PROTEIN KINASE C epsilon REGULATION OF VASCULAR REACTIVITY AFTER HEMORRHAGIC SHOCK IN RATS. SHOCK 42:239-245(2014).
Locatelli, M; Buelli, S; et al. Shiga Toxin Promotes Podocyte Injury in Experimental Hemolytic Uremic Syndrome via Activation of the Alternative Pathway of Complement. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 25:1786-1798(2014).