INHBB
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Official Full Name
inhibin, beta B
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Overview
Type I Diabetes is mainly characterised by limited or fully missing secretion of the hormone insulin. Morphological studies demonstrated a destruction of the beta cells of the so-called Langerhans cells (islet cells) in type I diabetics. Numerous researchers described the appearance of antibodies directed against the islet cells and insulin as the causal reason for the onset of the disease.<br/>Anti-Insulin antibodies are found in 37 percent of patients with newly detected Type I Diabetes, in 4 percent of their relatives of the first degree and in up to 1.5 percent of healthy controls. A positive correlation between the appearance of anti-Insulin and anti-islet cell antibodies has been reported. Anti-Insulin autoantibodies may be detected several months and in some cases years before the onset of the fully clinical manifestation of the diseases. Occasionally also autoantibodies to Pro-Insulin may appear.<br/>These ''true'' anti-Insulin autoantibodies directed against endogenous insulin have to be distinguished from those autoantibodies which are developed in insulin dependent diabetics undergoing therapy with insulin preparations of animal origin. In fact the latter have to be referred to side effects. These side effects may occur as local reactions of the skin by development of insulin-specific autoantibodies. These autoantibodies are causing the formation of an insulin depot and they may simulate a resistance against the hormonal treatment with animal insulin. Additionally other immunological phenomenon have been reported for Type I diabetics. A lot of other autoantibody specificities have been detected in those patients, too, but these antibodies must not cause additional autoimmune phenomenon. -
Synonyms
INHBB; inhibin, beta B; inhibin, beta B (activin AB beta polypeptide); inhibin beta B chain; Inhibin, beta-2; activin beta-B chain; activin AB beta polypeptide; MGC157939;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Pig
- Rat
- Zebrafish
- CHO
- E.coli
- HEK293
- Hi-5 Insect Cell
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Nicotiana Benthamiana
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His(C
- ter)
- His|GST
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | INHBB-956H | Active Recombinant Human INHBB Protein | Hi-5 Insect Cell | N/A | ||
Human | INHBA&INHBB-146H | Active Recombinant Human INHBA&INHBB, His-tagged, Animal Free | Nicotiana Benthamiana | His | ||
Human | INHBA&INHBB-736H | Active Recombinant Human INHBA&INHBB | CHO | N/A | ||
Human | INHBB-139H | Active Recombinant Human INHBB, Animal Free | Nicotiana Benthamiana | N/A | ||
Human | INHBB-1764H | Recombinant Human INHBB protein, His & GST-tagged | E.coli | His/GST | Gly50~Cys404 | |
Human | INHBA&INHBB-1544H | Recombinant human Activin AB, Active, His-tagged | Nicotiana Benthamiana | His | ||
Human | INHBB-2885H | Recombinant Human Activin B | Insect Cell | N/A | ||
Human | INHBB-2261H | Active Recombinant Human INHBB protein(Met1-Ala407), His-tagged | HEK293 | C-His | Met1-Ala407 | |
Human | INHBB-1546H | Recombinant human Activin B, Active, His-tagged | Nicotiana Benthamiana | His | ||
Human | INHBB-138H | Recombinant Human INHBB, Animal Free | Nicotiana Benthamiana | N/A | ||
Human | INHBB-1763H | Recombinant Human INHBB protein, His-tagged | E.coli | His | Gly293~Ala407 (Accession # P09529) | |
Human | INHBB-1545H | Recombinant human Activin B | Nicotiana Benthamiana | N/A | ||
Human | Activin-B-3122H | Recombinant Human Activin-B | Nicotiana Benthamiana | N/A | 407 | |
Human | INHBB-2612HCL | Recombinant Human INHBB cell lysate | Human Cell | N/A | ||
Human | INHBB-3116H | Recombinant Human INHBB Protein (Gly293-Ala407), C-His tagged | Mammalian cells | C-His | Gly293-Ala407 | |
Human | INHBB-185H | Active Recombinant Human INHBB Protein (Gly293-Ala407), C-His tagged, Animal-free, Carrier-free | E.coli | C-His | Gly293-Ala407 | |
Human | INHBB-5119H | Active Recombinant Human INHBB Protein | Insect Cell | N/A | ||
Human | INHBB-5118H | Recombinant Human INHBB Protein, GST-tagged | Wheat Germ | GST | ||
Human | INHBB-5890HF | Recombinant Full Length Human INHBB Protein, GST-tagged | In Vitro Cell Free System | GST | 407 amino acids | |
Human | INHBB-222H | Recombinant Active Human INHBB Protein, His-tagged(C-ter) | E.coli | His(C-ter) | ||
Human | INHBB-01H | Recombinant Human INHBB Protein | CHO | |||
Mouse | Inhbb-1765M | Recombinant Mouse Inhbb protein, His-tagged | E.coli | His | Gly297~Ala411 (Accession # Q04999) | |
Mouse | INHBB-8214M | Recombinant Mouse INHBB Protein | Mammalian Cell | His | ||
Mouse | INHBB-4548M-B | Recombinant Mouse INHBB Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | INHBB-4548M | Recombinant Mouse INHBB Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Inhbb-221M | Recombinant Active Mouse INHBB Protein, His-tagged(C-ter) | E.coli | His(C-ter) | ||
Mouse | Inhbb-64M | Active Recombinant Mouse Inhbb Protein (Gly297-Ala411), C-His tagged, Animal-free, Carrier-free | E.coli | C-His | Gly297-Ala411 | |
Rat | Inhbb-1767R | Recombinant Rat Inhbb protein, His-tagged | E.coli | His | Gly297~Ala411 (Accession # P17491) | |
Rat | INHBB-3066R | Recombinant Rat INHBB Protein | Mammalian Cell | His | ||
Rat | INHBB-2722R | Recombinant Rat INHBB Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | INHBB-2722R-B | Recombinant Rat INHBB Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | INHBB-8696Z | Recombinant Zebrafish INHBB | Mammalian Cell | His | ||
Pig | INHBB-1766P | Recombinant Pig INHBB protein, His-tagged | E.coli | His | Gly293~Ala407 (Accession # P04088) | |
Chicken | INHBB-6759C | Recombinant Chicken INHBB | Mammalian Cell | His | ||
Chicken | INHBB-1762C | Recombinant Chicken INHBB protein, His-tagged | E.coli | His | Gly277~Ala391 (Accession # P27093) |
- Involved Pathway
- Protein Function
- Interacting Protein
- INHBB Related Research Area
INHBB involved in several pathways and played different roles in them. We selected most pathways INHBB participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with INHBB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | IL-15RA;Ifna15;BMPR1B;CCL18;PF4V1;IFNPHI3;TNFRSF19;IL28A;IL12B |
TGF-beta signaling pathway | ACVR1C;BMPR1AA;RPS6KB1B;CUL1;FST;TGFBR2;ID1;ACVR1L;RBX1 |
Signaling pathways regulating pluripotency of stem cells | MAPK11;SMARCAD1;PIK3R1;BMPR1A;HESX1;MAPK13;MAP2K1;AXIN1;PAX6 |
INHBB has several biochemical functions, for example, cytokine activity, growth factor activity, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INHBB itself. We selected most functions INHBB had, and list some proteins which have the same functions with INHBB. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
cytokine activity | TNFSF13B;SCGB3A1;CD70;Il1f6;IFNA21;TNFSF4;INHBAB;VEGFA;Il1f9 |
growth factor activity | NENF;FGF8A;NODAL;FGF5;TDGF1;Artn;NRTN;THBS4;GDF6 |
hormone activity | GNRH3;IGF2B;UTS2D;PTH1A;UCN3;UCN2;APLN;PRL3C1;STC2 |
host cell surface receptor binding | |
protein binding | SOCS6;USP17L2;CCDC53;WT1;EFS;RBM15;MRFAP1L1;STMN2;TRPV5 |
protein homodimerization activity | PAFAH1B2;CADM1;SFTPC;PITX2;AXIN1;SLC11A1;TNNC1;MUC13;PPP2R4 |
transforming growth factor beta receptor binding | INHBA;SPAW;BMP8B;USP15;NDR1;GDF10;MSTN;GDF2;BMP7B |
INHBB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INHBB here. Most of them are supplied by our site. Hope this information will be useful for your research of INHBB.
ACVR1C; FNTA
- Q&As
- Reviews
Q&As (7)
Ask a questionINHBB is encoded by the INHBB gene.
INHBB plays a role in regulating reproductive functions.
Mutations in the INHBB gene can be linked to reproductive disorders.
The molecular weight is approximately 43 kDa.
INHBB is often expressed in the testes and ovaries.
The full name is “Inhibin subunit beta B.”
Yes, INHBB can interact with various proteins involved in reproductive pathways.
Customer Reviews (3)
Write a reviewIt met stringent safety standards, allowing us to work with confidence in a controlled laboratory environment.
We observed minimal changes in results even after prolonged storage, showcasing its long-term stability.
The product’s durability allowed us to confidently plan experiments without concerns about degradation.
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