IRF5 Protein, interferon regulatory factor 5

IRF5

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IRF5

Official Full Name interferon regulatory factor 5
Background This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.
Synonyms IRF5; interferon regulatory factor 5; SLEB10; IRF-5; OTTHUMP00000212904; OTTHUMP00000212905; OTTHUMP00000212907; OTTHUMP00000212910
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IRF5-299H Recombinant Human IRF5 protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human IRF5-587H Recombinant Human IRF5 protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human IRF5-588H Recombinant Human IRF5 protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human IRF5-589H Recombinant Human IRF5 protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human IRF5-590H Recombinant Human IRF5 protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human IRF5-591H Recombinant Human IRF5 protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human IRF5-592H Recombinant Human IRF5 protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human IRF5-593H Recombinant Human IRF5 protein, His-tagged E.coli His
    Mouse Irf5-594M Recombinant Mouse Irf5 protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human IRF5-595H Recombinant Human IRF5 protein, His-tagged E.coli His
    Human IRF5-001H Recombinant Human IRF5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human IRF5-002H Recombinant Human IRF5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human IRF5-003H Recombinant Human IRF5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human IRF5-004H Recombinant Human IRF5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human IRF5-005H Recombinant Human IRF5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human IRF5-006H Recombinant Human IRF5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human IRF5-007H Recombinant Human IRF5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human IRF5-008H Recombinant Human IRF5 Protein, His-tagged E. coli His
    Human IRF5-009H Recombinant Human IRF5 Protein, His-tagged E. coli His
    Mouse Irf5-010M Recombinant Mouse Irf5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human IRF5-011H Recombinant Human IRF5 Protein, His-tagged E. coli His
    Mouse IRF5-585M Recombinant Mouse IRF5 Protein (1-497 aa), His-SUMO-tagged E.coli His/SUMO
    Human IRF5-5037H Recombinant Human IRF5 Protein, GST-tagged Wheat Germ GST
    Human IRF5-5121H Recombinant Human IRF5, His-tagged E.coli His
    Human IRF5-5162HCL Recombinant Human IRF5 293 Cell Lysate HEK293 N/A
    Human IRF5-5163HCL Recombinant Human IRF5 293 Cell Lysate HEK293 N/A
    Human IRF5-5164HCL Recombinant Human IRF5 293 Cell Lysate HEK293 N/A
    Mouse Irf5-7159M Recombinant Mouse Irf5 protein, His & T7-tagged E.coli His/T7
    Mouse IRF5-8303M Recombinant Mouse IRF5 Protein Mammalian Cell His
    Chicken IRF5-3228C Recombinant Chicken IRF5 Mammalian Cell His
    Zebrafish IRF5-12134Z Recombinant Zebrafish IRF5 Mammalian Cell His

    IRF5 involved in several pathways and played different roles in them. We selected most pathways IRF5 participated on our site, such as Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Toll-like receptor signaling pathway IFNA10; MAPK11; CD86; IFNA2; IFNA13; RELA; TRAF6; IFNAR1; IRAK4; IFNPHI1

    IRF5 has several biochemical functions, for example, protein binding, regulatory region DNA binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF5 itself. We selected most functions IRF5 had, and list some proteins which have the same functions with IRF5. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PLOD3; BCR; DSCAM; AICDA; UBAC1; EMP1; KITLG; ITM2C; KBTBD6; RAD18
    regulatory region DNA binding IRF6; IRF4A; IRF5; NFKB1; HMGA2; IRF3; IRF2A; IRF8; IRF1B; IRF1A
    transcription factor activity, sequence-specific DNA binding RXRB; SOX4; PCGF2; ASCL1B; ZBTB14; ZFP367; DMRT3; PLAG1; ZNF239; TADA2A

    IRF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF5.

    SGTA; RELA; MAVS; tnfa_human_isre1_dna-probe; TNF; GTPBP1; IRF6; PPM1G; CEP152; HIVEP1; RGS3

    Ren, JY; Chen, X; et al. IKK beta is an IRF5 kinase that instigates inflammation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:17438-17443(2014).
    AlFadhli, S; Jahabani, I; et al. Association of interferon regulatory factor 5 (IRF5) markers with an increased risk of lupus and overlapping autoimmunity in a Kuwaiti population. ANNALS OF HUMAN BIOLOGY 41:531-539(2014).

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