irf5
Share
  • Official Full Name
  • interferon regulatory factor 5
  • Background
  • This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.
  • Synonyms
  • IRF5; interferon regulatory factor 5; SLEB10; IRF-5; OTTHUMP00000212904; OTTHUMP00000212905; OTTHUMP00000212907; OTTHUMP00000212910
Cat.#:IRF5-585MTag:His-SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse IRF5 Protein (1-497 aa), His-SUMO-tagged
+Inquiry
Cat.#:IRF5-5037HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IRF5 Protein, GST-tagged
+Inquiry
Cat.#:IRF5-28725THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IRF5
+Inquiry
Cat.#:IRF5-5121HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF5, His-tagged
+Inquiry
Cat.#:IRF5-520HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human interferon regulatory factor 5, His-tagged
+Inquiry
Cat.#:Irf5-7159MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Irf5 protein, His & T7-tagged
+Inquiry
Cat.#:IRF5-8303MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IRF5 Protein
+Inquiry
Cat.#:IRF5-3228CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IRF5
+Inquiry
Cat.#:IRF5-12134ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IRF5
+Inquiry
Cat.#:IRF5-5162HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRF5 293 Cell Lysate
+Inquiry
Cat.#:IRF5-5163HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRF5 293 Cell Lysate
+Inquiry
Cat.#:IRF5-5164HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRF5 293 Cell Lysate
+Inquiry

Involved Pathway

IRF5 involved in several pathways and played different roles in them. We selected most pathways IRF5 participated on our site, such as Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Toll-like receptor signaling pathway
Ifna11; IFNAR1; TLR1LA; IFNA2; TRAF6; TRAF3; TLR1; TLR8; IFNA6; MAPK8B

Protein Function

IRF5 has several biochemical functions, for example, protein binding, regulatory region DNA binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF5 itself. We selected most functions IRF5 had, and list some proteins which have the same functions with IRF5. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein EIF4H; LGR6; NIPAL1; SCO2; KCNJ5; EHHADH; TTC30B; GTF2E1; GLS; THSD4
Function regulatory region DNA binding
Related Protein NFKB1; IRF4A; IRF3; IRF5; IRF1B; IRF1A; HMGA2; IRF2A; IRF8; IRF6
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF287; SUPT4H1; MGAA; HOXA4; DBPB; GATAD2A; TSC22D1; NPAS1; TCEAL1; FOXD4

Interacting Protein

IRF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF5.
SGTA; RELA; MAVS; tnfa_human_isre1_dna-probe; TNF; GTPBP1; IRF6; PPM1G; CEP152; HIVEP1; RGS3

IRF5 Related Articles

Ren, JY; Chen, X; et al. IKK beta is an IRF5 kinase that instigates inflammation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:17438-17443(2014).
AlFadhli, S; Jahabani, I; et al. Association of interferon regulatory factor 5 (IRF5) markers with an increased risk of lupus and overlapping autoimmunity in a Kuwaiti population. ANNALS OF HUMAN BIOLOGY 41:531-539(2014).