LEPR

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LEPR

Official Full Name leptin receptor
Background The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
Synonyms OBR; OB-R; CD295; LEP-R; LEPR; leptin receptor
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Rhesus monkey
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293F
    • Human Cell
    • Mammalian Cell
    • NSO
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • hIgG1
    • hIgG4
    • T7
    • human
    • IgG1
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LEPR-1249H Recombinant Human Leptin Receptor E.coli N/A
    Human LEPR-1662H Recombinant Human Leptin Receptor, Fc-His NSO Fc/His
    Human LEPR-2175HCL Recombinant Human LEPR cell lysate Human Cell N/A
    Human LEPR-29427TH Recombinant Human LEPR Wheat Germ N/A
    Human LEPR-3160H Recombinant Human LEPR, His tagged Human Cell His
    Human LEPR-505H Recombinant Human LEPR Mammalian Cell His
    Human LEPR-515H Recombinant Human LEPR protein, His-tagged HEK293F His
    Human LEPR-669H Recombinant Human LEPR protein, His & T7-tagged E.coli His/T7
    Human LEPR-799H Recombinant Human LEPR protein, Fc-tagged HEK293 human/IgG1/Fc
    Human LEPR-800H Recombinant Human LEPR, Fc-His tagged Human Cell Fc/His
    Human LEPR-801H Recombinant Human LEPR Wheat Germ N/A
    Mouse Lepr-01M Recombinant Mouse Lepr, His-tagged Human Cell His
    Mouse Lepr-1766M Recombinant Mouse Leptin Receptor NSO N/A
    Mouse Lepr-670M Recombinant Mouse Lepr protein, His & T7-tagged E.coli His/T7
    Mouse LEPR-9049M Recombinant Mouse LEPR Protein Mammalian Cell His
    Rat Lepr-671R Recombinant Rat Lepr protein, His & T7-tagged E.coli His/T7
    Rhesus monkey LEPR-1688R Recombinant Rhesus Monkey LEPR Protein HEK293 N/A
    Rhesus monkey LEPR-1689R Recombinant Rhesus Monkey LEPR Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey LEPR-1690R Recombinant Rhesus Monkey LEPR Protein, hIgG4-tagged HEK293 hIgG4
    Rhesus Macaque LEPR-2497R Recombinant Rhesus monkey LEPR Protein, His-tagged Mammalian Cell His
    Chicken LEPR-1250C Recombinant Chicken Leptin Receptor E.coli N/A
    Chicken LEPR-5896C Recombinant Chicken LEPR Mammalian Cell His
    Zebrafish LEPR-6284Z Recombinant Zebrafish LEPR Mammalian Cell His

    LEPR involved in several pathways and played different roles in them. We selected most pathways LEPR participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CXCL1; CCL27; ACKR3B; CCL20; CXCL8; GHRA; TNFRSF1B; IL17RA; TNFRSF18; TNFSF11
    Neuroactive ligand-receptor interaction GRIA3B; TAAR14I; P2RY8; P2RX4A; THRB; CALCRL; GPR156; OXTR; GABRQ; S1PR5A
    AMPK signaling pathway RPS6KB1; CCNA1; CREB3L3; AKT2; PPP2R5C; FBP1; MTOR; Scd2; PRKAA1; INS1
    Jak-STAT signaling pathway IL7R; IFNA2; IFNA6; MCL1; SOCS9; CSH2; CRLF2; IFNA8; IL15; BCL2L1
    Adipocytokine signaling pathway PRKAA2; PCK1; G6PC; PRKAB1B; CHUK; MAPK10; ACSL3; ACSL1B; PRKAG3; NPY
    Non-alcoholic fatty liver disease (NAFLD) MAPK10; CASP7; NDUFA4; PIK3R2; PRKAA1; NDUFV1; UQCRC2; NDUFS3; NDUFB8; NDUFB2

    LEPR has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by LEPR itself. We selected most functions LEPR had, and list some proteins which have the same functions with LEPR. You can find most of the proteins on our site.

    Function Related Protein
    cytokine receptor activity CRFB4; IRX1; LIFRB; CRFB15; PRLRA; IL12RB2; IL2RGB; IL4R.1; IL13RA1; IL11RA
    identical protein binding B2M; PHYKPL; SERPINA1D; ITGA2B; COL1A1; SMAD1; PTPRM; IFIT3; GOT1; TYSND1
    protein binding DMC1; NFKBIL1; ACTR6; PPP1R2P9; RNF168; ALDOC; ITGA4; CD274; PLSCR1; HOMEZ
    transmembrane signaling receptor activity IL11RA; LILRB3; SLAMF1; CELSR1; GPR98; CD97; ADCYAP1R1A; FCGR2C; PTH1RA; CLDN3

    LEPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEPR here. Most of them are supplied by our site. Hope this information will be useful for your research of LEPR.

    PTPN11; PTPRC; PTPRJ; GRB2; CSNK2B; PIN1; JAK2; JAK3

    Kapodistria, K; Tsilibary, EP; et al. Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling. MOLECULAR AND CELLULAR ENDOCRINOLOGY 400:112-128(2015).
    Lei, MM; Wu, SQ; et al. Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens. DOMESTIC ANIMAL ENDOCRINOLOGY 50:55-64(2015).

    IL

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