lepr
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  • Official Full Name
  • leptin receptor
  • Background
  • The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
  • Synonyms
  • OBR; OB-R; CD295; LEP-R; LEPR; leptin receptor
Cat.#:LEPR-1249HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Leptin Receptor
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Cat.#:LEPR-1662HTag:FC/His
Source (Host):NS0Species:Human
Product nameRecombinant Human Leptin Receptor, Fc-His
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Cat.#:LEPR-29427THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human LEPR
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Cat.#:LEPR-3160HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LEPR, His tagged
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Cat.#:LEPR-505HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human LEPR
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Cat.#:LEPR-515HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human LEPR protein, His-tagged
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Cat.#:LEPR-669HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEPR protein, His & T7-tagged
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Cat.#:LEPR-799HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human LEPR, Fc-tagged
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Cat.#:LEPR-800HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LEPR, Fc-His tagged
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Cat.#:LEPR-801HTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human LEPR
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Cat.#:Lepr-01MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Lepr, His-tagged
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Cat.#:Lepr-1766MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Leptin Receptor
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Cat.#:Lepr-670MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lepr protein, His & T7-tagged
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Cat.#:LEPR-9049MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LEPR Protein
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Cat.#:Lepr-671RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lepr protein, His & T7-tagged
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Cat.#:LEPR-1688RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey LEPR Protein
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Cat.#:LEPR-1689RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey LEPR Protein, hIgG1-tagged
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Cat.#:LEPR-1690RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey LEPR Protein, hIgG4-tagged
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Cat.#:LEPR-2497RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey LEPR Protein, His-tagged
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Cat.#:LEPR-5896CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LEPR
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Cat.#:LEPR-6284ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LEPR
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Cat.#:LEPR-1250CTag:N/A
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken Leptin Receptor
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Cat.#:LEPR-2175HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human LEPR cell lysate
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Involved Pathway

LEPR involved in several pathways and played different roles in them. We selected most pathways LEPR participated on our site, such as Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCR7; PDGFC; LEPA; IL21R; CLCF1; IL18R1; CCL25B; CCR5; XCR1; EDA
Neuroactive ligand-receptor interaction
PTGER1; GRIN2D; GRIA2A; GRIN2BB; GABRA4; GRIK3; OPRD1B; FSHR; CHRM5B; GRIN1A
AMPK signaling pathway
G6PC; SREBF1; INS; ADRa1A; CPT1A; RPS6KB2; PPARG; PPP2CA; MLYCD; PIK3R2
Jak-STAT signaling pathway
IL20RA; STAT6; IL2RGA; M17; Ifna11; Ifna15; RNF207B; JAK2A; PTPN6; IL7
Adipocytokine signaling pathway
PRKAB1B; MAPK9; IKBKB; TRADD; NPY; LEP; ACSBG2; CAMKK1; JAK2; ACACB
Non-alcoholic fatty liver disease (NAFLD)
ADIPOQ; PIK3CG; XBP1; PRKAG2; PRKAB1; NDUFB5; NDUFA5; NDUFB7; SDHA; MAPK9

Protein Function

LEPR has several biochemical functions, for example, cytokine receptor activity, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEPR itself. We selected most functions LEPR had, and list some proteins which have the same functions with LEPR. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine receptor activity
Related Protein IL12RB1; IL20RB; CSF3R; CRFB12; CRFB16; IL13RA2; Il6ra; GHRA; IL17RB; GHR
Function identical protein binding
Related Protein MVK; DPP9; ZDHHC17; CEACAM16; SMURF2; TPCN2; COL7A1; PRPF3; SAFB2; UGP2
Function protein binding
Related Protein SIX1; FAM164A; MED23; TEX14; DSCAM; BMF; HEY2; PIP4K2B; KCNRG; RTF1
Function transmembrane signaling receptor activity
Related Protein GIPR; FCGR2C; FZD1; BCAM; M6PR; OR4D2; OR103-4; NRXN1; OR4C12; OR4N4

Interacting Protein

LEPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEPR here. Most of them are supplied by our site. Hope this information will be useful for your research of LEPR.
PTPN11; PTPRC; PTPRJ; GRB2; CSNK2B; PIN1; JAK2; JAK3

LEPR Related Articles

Kapodistria, K; Tsilibary, EP; et al. Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling. MOLECULAR AND CELLULAR ENDOCRINOLOGY 400:112-128(2015).
Lei, MM; Wu, SQ; et al. Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens. DOMESTIC ANIMAL ENDOCRINOLOGY 50:55-64(2015).

LEPR Related Gene Family

IL