Active Recombinant Human LEPR Protein, His&Avi tagged

• Cat.No.: LEPR-75H
• Product Overview: ObR protein dimer contains an ObR extracellular domain (UniProt# P48357) fused with a proprietary cis-dimer motif followed by a tandem His-Avi tag at the C-terminus.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 22-839 aa
• Description: Human obesity receptor (ObR) is a Type I transmembrane receptor belonging to the cytokine receptor family. ObR is the receptor of leptin, a hormone secreted by fat cells that plays a crucial role in regulating appetite, metabolism, and energy homeostasis. ObR is also known as OB-R, leptin receptor (LEPR), LEPRD, and cluster of differentiation 295 (CD295). ObR contains an extracellular domain with an N-terminal cytokine receptor homology domain (CRH-1); an immunoglobulin-like (Ig-like) domain; a second CRH domain (CRH-2), also referred to as the leptin-binding domain (LBD); and two fibronectin type III (FNIII) domains followed by a transmembrane domain and cytoplasmic domain. ObR functions as a dimer to mediate leptin signaling. ObR binds leptin and its activity regulates adipose-tissue mass making ObR an attractive target when it comes to combating obesity.
• Molecular Mass: 207 kDa
• Homodimer/Heterodimer: Homodimer
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for ObR-specific antibody and leptin ligand protein binding assays. Suggested Applications: ELISA for ObR-specific antibody and leptin ligand protein binding assays. SPR & BLI for ObR-specific antibody and leptin protein binding assays. Animal immunization, RUO.
• Storage: At -80 centigrade
• Storage Buffer: 0.2μm filtered PBS, pH 7.4, no preservatives
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name 2: LEPR leptin receptor [Homo sapiens (human)]
• Official Symbol 2: LEPR
• Synonyms 2: LEPR; leptin receptor; CD295; OBR; huB219; OB receptor; OB-R; LEP-R; DKFZp686B1731
• Gene ID 2: 3953
• mRNA Refseq 2: NM_001003679
• Protein Refseq 2: NP_001003679
• MIM 2: 601007
• UniProt ID 2: P48357
• Gene Name: IL2RG interleukin 2 receptor, gamma [Homo sapiens (human)]
• Official Symbol: IL2RG
• Synonyms: IL2RG; interleukin 2 receptor, gamma; CIDX, combined immunodeficiency, X linked, IMD4, SCIDX1, severe combined immunodeficiency; cytokine receptor common subunit gamma; CD132; gammaC; gamma(c); CD132 antigen; common gamma-chain; IL-2R subunit gamma; IL-2 receptor subunit gamma; severe combined immunodeficiency; combined immunodeficiency, X-linked; common cytokine receptor gamma chain; interleukin-2 receptor subunit gamma; P64; CIDX; IMD4; SCIDX; IL-2RG; SCIDX1
• Gene ID: 3561
• mRNA Refseq: NM_000206
• Protein Refseq: NP_000197
• MIM: 308380
• UniProt ID: P31785