LIN28A Protein, lin-28 homolog A (C. elegans)


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Official Full Name lin-28 homolog A (C. elegans)
Background Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.
Synonyms LIN28A; lin-28 homolog A (C. elegans); CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A; protein lin-28 homolog A; RNA-binding protein LIN-28; zinc finger, CCHC domain containing 1; zinc finger CCHC domain-containing protein 1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Tag :
    • Arg
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LIN28A-129H Recombinant Human LIN28A protein, Arginine-tagged E.coli Arg
    Human LIN28A-1577H Recombinant Human LIN28A protein E.coli N/A
    Human LIN28A-29947TH Recombinant Human LIN28A E.coli N/A
    Human LIN28A-4734HCL Recombinant Human LIN28A 293 Cell Lysate HEK293 N/A
    Human LIN28A-643H Recombinant Human LIN28A Protein E.coli N/A
    Human LIN28A-8467H Recombinant Human LIN28A, His-tagged E.coli His
    Human PF4V1-257H Recombinant Human Lin-28 Homolog A (C. elegans), His-tagged Human His
    Mouse LIN28A-9112M Recombinant Mouse LIN28A Protein Mammalian Cell His
    Chicken LIN28A-3254C Recombinant Chicken LIN28A Mammalian Cell His
    Zebrafish LIN28A-11314Z Recombinant Zebrafish LIN28A Mammalian Cell His

    LIN28A involved in several pathways and played different roles in them. We selected most pathways LIN28A participated on our site, such as Cardiac Progenitor Differentiation, Developmental Biology, Transcriptional regulation of pluripotent stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIN28A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cardiac Progenitor Differentiation NIPAL1; ZFP42; LIN28B; NKX2; ROR2; LIN28A; SIRPA; IRX4; NOG; TBX5
    Developmental Biology COL6A1; RGMB; HELZ2; COL9A1A; PTPRA; GPC1A; COL6A3; DPYSL2B; KBTBD7; ACTR2B
    Transcriptional regulation of pluripotent stem cells NR6A1; HIF3A; TDGF1; LIN28A; NR5A1; POU5F3; PRDM14; FOXD3; SALL4

    LIN28A has several biochemical functions, for example, DNA binding, RNA binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIN28A itself. We selected most functions LIN28A had, and list some proteins which have the same functions with LIN28A. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding TCF7L1B; UPF1; HIST1H2BK; PAX4; ZNF530; RX1; ZBTB39; CXXC1A; GZF1; HOXC9A
    mRNA binding TSN; HNRNPAB; DCP1B; IGF2BP2A; TDRD7; RPS13; RPL13A; ZFP36; DXO; LUC7L3
    miRNA binding EIF2C3; MEF2C; POU5F1; SOX2; DICER1; AGO4; LIN28A; TRIM71; TARBP2; AGO1
    protein binding MPL; IRF5; ASB2; DHH; STRAP; NUDCD3; GRIN2B; KLK4; TET2; RRAGA
    translation initiation factor binding POLR2GL; EIF3F; POLR2D; EIF2B4; LIN28A; EIF3B; ZFP259; POLR2G; CELF1; TRIM32
    zinc ion binding SNRPC; LIMS1; ERAP1; CBLL1; ZRANB2; MMP7; ZDHHC16; LIMS3L; FHL2B; KAT7

    LIN28A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIN28A here. Most of them are supplied by our site. Hope this information will be useful for your research of LIN28A.

    ZCCHC11; pre-let-7a; ZDHHC17

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