|Official Full Name||lin-28 homolog A (C. elegans)|
|Background||Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.|
|Synonyms||LIN28A; lin-28 homolog A (C. elegans); CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A; protein lin-28 homolog A; RNA-binding protein LIN-28; zinc finger, CCHC domain containing 1; zinc finger CCHC domain-containing protein 1;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
LIN28A involved in several pathways and played different roles in them. We selected most pathways LIN28A participated on our site, such as Cardiac Progenitor Differentiation, Developmental Biology, Transcriptional regulation of pluripotent stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIN28A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cardiac Progenitor Differentiation||NIPAL1; ZFP42; LIN28B; NKX2; ROR2; LIN28A; SIRPA; IRX4; NOG; TBX5|
|Developmental Biology||COL6A1; RGMB; HELZ2; COL9A1A; PTPRA; GPC1A; COL6A3; DPYSL2B; KBTBD7; ACTR2B|
|Transcriptional regulation of pluripotent stem cells||NR6A1; HIF3A; TDGF1; LIN28A; NR5A1; POU5F3; PRDM14; FOXD3; SALL4|
LIN28A has several biochemical functions, for example, DNA binding, RNA binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIN28A itself. We selected most functions LIN28A had, and list some proteins which have the same functions with LIN28A. You can find most of the proteins on our site.
|DNA binding||TCF7L1B; UPF1; HIST1H2BK; PAX4; ZNF530; RX1; ZBTB39; CXXC1A; GZF1; HOXC9A|
|RNA binding||KIAA0430; ELAVL4; HNRNPF; CWC22; ILF3; NSUN3; ADARB1; UBR5; MIF4GD; SRBD1|
|mRNA binding||TSN; HNRNPAB; DCP1B; IGF2BP2A; TDRD7; RPS13; RPL13A; ZFP36; DXO; LUC7L3|
|miRNA binding||EIF2C3; MEF2C; POU5F1; SOX2; DICER1; AGO4; LIN28A; TRIM71; TARBP2; AGO1|
|protein binding||MPL; IRF5; ASB2; DHH; STRAP; NUDCD3; GRIN2B; KLK4; TET2; RRAGA|
|translation initiation factor binding||POLR2GL; EIF3F; POLR2D; EIF2B4; LIN28A; EIF3B; ZFP259; POLR2G; CELF1; TRIM32|
|zinc ion binding||SNRPC; LIMS1; ERAP1; CBLL1; ZRANB2; MMP7; ZDHHC16; LIMS3L; FHL2B; KAT7|
LIN28A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIN28A here. Most of them are supplied by our site. Hope this information will be useful for your research of LIN28A.
ZCCHC11; pre-let-7a; ZDHHC17