lin28a
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  • Official Full Name
  • lin-28 homolog A (C. elegans)
  • Background
  • Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.
  • Synonyms
  • LIN28A; lin-28 homolog A (C. elegans); CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A; protein lin-28 homolog A; RNA-binding protein LIN-28; zinc finger, CCHC domain containing 1; zinc finger CCHC domain-containing protein 1;
Cat.#:LIN28A-643HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LIN28A Protein
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Cat.#:LIN28A-129HTag:Arg
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LIN28A protein, Arginine-tagged
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Cat.#:LIN28A-1577HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human LIN28A protein
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Cat.#:LIN28A-29947THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LIN28A
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Cat.#:LIN28A-8467HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LIN28A, His-tagged
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Cat.#:PF4V1-257HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Lin-28 Homolog A (C. elegans), His-tagged
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Cat.#:LIN28A-9112MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LIN28A Protein
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Cat.#:LIN28A-3254CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LIN28A
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Cat.#:LIN28A-11314ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LIN28A
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Cat.#:LIN28A-4734HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LIN28A 293 Cell Lysate
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Involved Pathway

LIN28A involved in several pathways and played different roles in them. We selected most pathways LIN28A participated on our site, such as Cardiac Progenitor Differentiation, Developmental Biology, Transcriptional regulation of pluripotent stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIN28A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cardiac Progenitor Differentiation
TBX20; NKX2; IRX4; BMP1; LIN28B; ROR2; ZFP42; NOG; LIN28A; TBX5
Developmental Biology
WDR83; RANBP9; CAP1; SREBF2; EGR2; CSNK2A2; SEMA3A; CNKSR1; LGI1B; SCN2A
Transcriptional regulation of pluripotent stem cells
NR5A1; SALL4; LIN28A; POU5F3; PRDM14; FOXD3; TDGF1; HIF3A; NR6A1

Protein Function

LIN28A has several biochemical functions, for example, DNA binding, RNA binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIN28A itself. We selected most functions LIN28A had, and list some proteins which have the same functions with LIN28A. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein H2AFX; GLYR1; TBX3A; BLZF1; POGZ; SOX1B; LBX2; ZNF83; DNMT1; AIFM2
Function RNA binding
Related Protein RPS3A; HNRNPAB; CELF5; D19BWG1357E; ZBP1; KHNYN; HNRPK; IFIT12; RALY; DDX59
Function mRNA binding
Related Protein RBM38; LIN28A; RBFOX2; SNRNP35; RBMY1A1; MRPL13; D19BWG1357E; NUDT21; PIWIL2; ZFP36L1
Function miRNA binding
Related Protein EIF2C3; TRIM71; SOX2; RBM4; AGO4; POU5F1; DICER1; AGO1; LIN28A; TARBP2
Function protein binding
Related Protein STX19; TMPO; ZNF230; MOBKL1A; ABI1; CLEC16A; cgr2b; TINF2; PPP2R2C; H3F3B
Function translation initiation factor binding
Related Protein LIN28A; TRIM32; EIF2B3; EIF2B5; CELF1; EIF3BA; EIF3M; RPS24; TBL2; EIF3B
Function zinc ion binding
Related Protein HIF1AN; RNF182; ADAM10; SIAH2L; RNF144B; RERE; FBXO11; PIAS1; WBP7; KAT6A

Interacting Protein

LIN28A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIN28A here. Most of them are supplied by our site. Hope this information will be useful for your research of LIN28A.
ZCCHC11; pre-let-7a; ZDHHC17