lipa
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  • Official Full Name
  • lipase A, lysosomal acid, cholesterol esterase
  • Background
  • This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
  • Synonyms
  • LIPA; lipase A, lysosomal acid, cholesterol esterase; LAL; CESD; lysosomal acid lipase/cholesteryl ester hydrolase; sterol esterase; cholesteryl esterase; lysosomal acid lipase; cholesterol ester hydrolase; acid cholesteryl ester hydrolase;
Cat.#:LIPA-2158HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human LIPA Protein (22-399 aa), His-tagged
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Cat.#:LIPA-2402BTag:His
Source (Host):YeastSpecies:Bartonella Henselae
Product nameRecombinant Bartonella Henselae LIPA Protein (1-320 aa), His-tagged
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Cat.#:LIPA-627HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LIPA Protein (22-399 aa), GST-tagged
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Cat.#:LIPA-11HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human LIPA, MYC/DDK-tagged
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Cat.#:Lipa-7937MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lipa protein, His & T7-tagged
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Cat.#:Lipa-7938RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lipa protein, His & T7-tagged
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Cat.#:LIPA-2523RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey LIPA Protein, His-tagged
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Cat.#:LIPA-2533BTag:His
Source (Host):E. coli or YeastSpecies:Bacillus subtilis
Product nameRecombinant Bacillus subtilis LIPA protein, His-tagged
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Cat.#:LIPA-4727HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human LIPA 293 Cell Lysate
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Involved Pathway

LIPA involved in several pathways and played different roles in them. We selected most pathways LIPA participated on our site, such as Steroid biosynthesis, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Steroid biosynthesis
HSD17B7; DHCR24; SC5DL; LSS; MSMO1; CYP2R1; CELL; SQLEA; FDFT1; CYP51
Lysosome
CTSF; ACP5A; DNASE2; HEXA; SLC17A5; LAMP2; AP4B1; AP3S2; AP3D1; MCOLN1

Protein Function

LIPA has several biochemical functions, for example, lipase activity, sterol esterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LIPA itself. We selected most functions LIPA had, and list some proteins which have the same functions with LIPA. You can find most of the proteins on our site.
Function
Related Protein
Function lipase activity
Related Protein PNPLA7; LIPM; GOLT1BB; DAGLB; ABHD2B; GOLT1A; LIPA; LIPK; C2orf43; GOLT1B
Function sterol esterase activity
Related Protein LIPA; CES5A; Cel; CES3; CEL.1; CES1D; CES1

LIPA Related Articles

Frohnecke, N; Klein, S; et al. Protein-protein interaction studies provide evidence for electron transfer from ferredoxin to lipoic acid synthase in Toxoplasma gondii. FEBS LETTERS 589:31-36(2015).
Zhao, FH; Zhu, FC; et al. Baseline prevalence and type distribution of human papillomavirus in healthy Chinese women aged 18-25 years enrolled in a clinical trial. INTERNATIONAL JOURNAL OF CANCER 135:2604-2611(2014).