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Recombinant Human LIPA Protein (22-399 aa), GST-tagged

Cat.No. : LIPA-627H
Product Overview : Recombinant Human LIPA Protein (22-399 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Research Area: Metabolism. Protein Description: Full Length of Mature Protein.
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Description : Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
Source : E. coli
Species : Human
Tag : GST
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 70.0 kDa
Protein length : 22-399 aa
AA Sequence : SGGKLTAVDPETNMNVSEIISYWGF PSEEYLVETEDGYILCLNRIPHGRK NHSDKGPKPVVFLQHGLLADSSNWV TNLANSSLGFILADAGFDVWMGNSR GNTWSRKHKTLSVSQDEFWAFSYDE MAKYDLPASINFILNKTGQEQVYYV GHSQGTTIGFIAFSQIPELAKRIKM FFALGPVASVAFCTSPMAKLGRLPD HLIKDLFGDKEFLPQSAFLKWLGTH VCTHVILKELCGNLCFLLCGFNERN LNMSRVDVYTTHSPAGTSVQNMLHW SQAVKFQKFQAFDWGSSAKNYFHYN QSYPPTYNVKDMLVPTAVWSGGHDW LADVYDVNILLTQITNLVFHESIPE WEHLDFIWGLDAPWRLYNKIINLMR KYQ
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Gene Name : LIPA lipase A, lysosomal acid, cholesterol esterase [ Homo sapiens ]
Official Symbol : LIPA
Synonyms : LIPA; CESD; LAL; Wolman disease; sterol esterase;
Gene ID : 3988
mRNA Refseq : NM_000235
Protein Refseq : NP_000226
MIM : 613497
UniProt ID : P38571

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does LIPA protein deficiency affect lipid metabolism? 04/30/2021

LIPA protein deficiency impairs the breakdown of cholesterol esters and triglycerides, leading to their accumulation in various tissues and organs.

How is LIPA protein deficiency diagnosed? 09/14/2020

Diagnosis of LIPA protein deficiency is typically made through genetic testing and measurement of LIPA enzyme activity in blood samples.

Are there any specific dietary recommendations for individuals with LIPA protein deficiency? 03/23/2020

Patients with LIPA protein deficiency are often advised to follow a low-fat, high-carbohydrate diet to help manage their lipid levels.

How does LIPA protein deficiency affect the liver? 01/06/2019

LIPA protein deficiency can result in the accumulation of cholesterol esters and triglycerides in the liver, leading to liver damage and dysfunction.

Are there any ongoing research efforts focused on LIPA protein and its clinical applications? 05/19/2016

Yes, researchers are actively studying LIPA protein deficiency and potential therapeutic approaches, including gene therapy and novel enzyme replacement strategies.

Customer Reviews (3)

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Reviews
03/02/2019

    Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.

    01/18/2018

      The reliable performance of the LIPA protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.

      03/05/2017

        Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.

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