Recombinant Human LIPA Protein (22-399 aa), His-tagged
Cat.No. : | LIPA-2158H |
Product Overview : | Recombinant Human LIPA Protein (22-399 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cardiovascular. Protein Description: Full Length of Mature Protein. |
- Specification
- Gene Information
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Description : | Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. |
Source : | Yeast |
Species : | Human |
Tag : | His |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 45.0 kDa |
Protein length : | 22-399 aa |
AA Sequence : | SGGKLTAVDPETNMNVSEIISYWGF PSEEYLVETEDGYILCLNRIPHGRK NHSDKGPKPVVFLQHGLLADSSNWV TNLANSSLGFILADAGFDVWMGNSR GNTWSRKHKTLSVSQDEFWAFSYDE MAKYDLPASINFILNKTGQEQVYYV GHSQGTTIGFIAFSQIPELAKRIKM FFALGPVASVAFCTSPMAKLGRLPD HLIKDLFGDKEFLPQSAFLKWLGTH VCTHVILKELCGNLCFLLCGFNERN LNMSRVDVYTTHSPAGTSVQNMLHW SQAVKFQKFQAFDWGSSAKNYFHYN QSYPPTYNVKDMLVPTAVWSGGHDW LADVYDVNILLTQITNLVFHESIPE WEHLDFIWGLDAPWRLYNKIINLMR KYQ |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA will be sent along with the products. Please refer to it for detailed information. |
Gene Name : | LIPA lipase A, lysosomal acid, cholesterol esterase [ Homo sapiens ] |
Official Symbol : | LIPA |
Synonyms : | LIPA; CESD; LAL; Wolman disease; sterol esterase; |
Gene ID : | 3988 |
mRNA Refseq : | NM_000235 |
Protein Refseq : | NP_000226 |
MIM : | 613497 |
UniProt ID : | P38571 |
Products Types
◆ Lysates | ||
LIPA-4727HCL | Recombinant Human LIPA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionLIPA protein deficiency impairs the breakdown of cholesterol esters and triglycerides, leading to their accumulation in various tissues and organs.
Diagnosis of LIPA protein deficiency is typically made through genetic testing and measurement of LIPA enzyme activity in blood samples.
Patients with LIPA protein deficiency are often advised to follow a low-fat, high-carbohydrate diet to help manage their lipid levels.
LIPA protein deficiency can result in the accumulation of cholesterol esters and triglycerides in the liver, leading to liver damage and dysfunction.
Yes, researchers are actively studying LIPA protein deficiency and potential therapeutic approaches, including gene therapy and novel enzyme replacement strategies.
Customer Reviews (3)
Write a reviewIts reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.
The reliable performance of the LIPA protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.
Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.
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