MAP3K14 Protein, mitogen-activated protein kinase kinase kinase 14

MAP3K14

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MAP3K14

Official Full Name mitogen-activated protein kinase kinase kinase 14
Background This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
Synonyms MAP3K14; mitogen-activated protein kinase kinase kinase 14; FTDCR1B; HS; HSNIK; NIK; serine/threonine protein kinase; NF-kappa-beta-inducing kinase; serine/threonine protein-kinase; serine/threonine-protein kinase NIK
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Source :
    • HEK293
    • Insect
    • Insect cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • GST-His
    • His
    • His&GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP3K14-01H Recombinant Human MAP3K14 Protein, GST&His-tagged Insect GST-His
    Human MAP3K14-894H Recombinant Human MAP3K14 Protein, His/GST-tagged Insect cell His&GST
    Human MAP3K14-1065 Recombinant Human MAP3K14 protein, GST-tagged Insect Cell GST
    Human MAP3K14-1065H Recombinant Human MAP3K14, GST-tagged Sf9 Insect Cell GST
    Human MAP3K14-30381TH Recombinant Human MAP3K14 N/A
    Human MAP3K14-4507HCL Recombinant Human MAP3K14 293 Cell Lysate HEK293 N/A
    Human MAP3K14-556H Recombinant Human MAP3K14, GST-tagged Sf9 Insect Cell GST
    Rhesus Macaque MAP3K14-2668R Recombinant Rhesus monkey MAP3K14 Protein, His-tagged Mammalian Cell His
    Chicken MAP3K14-2616C Recombinant Chicken MAP3K14 Mammalian Cell His

    MAP3K14 involved in several pathways and played different roles in them. We selected most pathways MAP3K14 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF6; RELA; MOS; RASGRF2B; NTRK2; MAP3K6; FLNC; TRP53; MEF2CB; RAF1B
    NF-kappa B signaling pathway CD14; PRKCQ; CXCL2; LTBR; BTK; PIDD1; CCL4L2; LTB; CCL13; ZAP70
    Apoptosis FADD; BCL2L11; SATB1; GZME; DFFA; CASP6; PPP3CCB; CASP10; BID; CASP8L1
    Osteoclast differentiation TYK2; RELA; MAP2K6; LILRB5; PPARG; IFNB1; IKBKB; PPP3R2; FCGR3; MAPK8
    T cell receptor signaling pathway PTPRC; FOS; RELA; CARD11; RHOA; NFATC1; BCL10; CD3E; MAPK3; RAF1
    TNF signaling pathway PIK3CD; NFKB1; MAPK3; PIK3CA; FAS; LIF; PIK3CG; MAP3K7; MAPK13; ATF4
    Intestinal i TNFRSF17; CD28; HLA-DQB1; MAP3K14; IL15RA; CD40; TGFB1; HLA-DMB; HLA-DRA; CXCR4
    ne network for IgA production Il2; HLA-DMA; TNFRSF17; BMA2; H2-AA; CXCR4B; TGFB1; TGFB1A; MAP3K14; CD86
    Epithelial cell signaling in Helicobacter pylori infection MAPK9; MAPK12; PAK1; ATP6V1G2; ATP6V0A2; GIT1; PTPN11; TJP1; MAPK11; F11R
    HTLV-I infection CALR; TP53INP1; VDAC1; VDAC2; IL2RG; HLA-DRB5; TGFB2; HLA-F; NRAS; SLC25A6
    Epstein-Barr virus infection RELA; YWHAE; EP300; POLR2L; TRAF6; HLA-DPB1; IKBKG; CD38; NFKBIA; TP53

    MAP3K14 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, MAP kinase kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K14 itself. We selected most functions MAP3K14 had, and list some proteins which have the same functions with MAP3K14. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PBK; ATP10A; cka1; MAP3K1; RPS6KA6; IGF1R; SARS; ACSM5; DDX41; ABCG1
    MAP kinase kinase activity MAPK10; MAP3K20; MAP2K7; MAP2K2A; MAP2K1; LRRK2; MAP2K2B; MAP3K9; ALPK2; MAP2K6
    MAP kinase kinase kinase activity MAP3K15; MAP3K1; MAP3K6; EGFR; YSK4; STK3; MAP3K4; ZAK; MAP3K12; MAP3K5
    NF-kappaB-inducing kinase activity PPP4C; MAP3K14; RIPK3; ALK; ALPK2; IRAK1; IKBKE
    protein binding PSRC1; ADCK3; CD2AP; GAB3; CUL4B; ITPR3; RAPGEF3; DLGAP1; ZRSR2; RNF10
    protein kinase activity NLK; SGK3; CAMK2B1; SNRKB; MKNK2A; GSG2; MAP3K12; CLK2A; GM711; NPR1
    protein serine/threonine kinase activity DYRK1A; PRKACAB; MAP4K4; PLK1; SGK1; MAP3K10; PKMYT1; SYK; NEK9; NEK10

    MAP3K14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K14.

    CHUK; IKBKB; ALPL; HSP90AB1; CDC37; TRAF6

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