map3k14
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  • Official Full Name
  • mitogen-activated protein kinase kinase kinase 14
  • Background
  • This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
  • Synonyms
  • MAP3K14; mitogen-activated protein kinase kinase kinase 14; FTDCR1B; HS; HSNIK; NIK; serine/threonine protein kinase; NF-kappa-beta-inducing kinase; serine/threonine protein-kinase; serine/threonine-protein kinase NIK
Cat.#:MAP3K14-1065Tag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human MAP3K14 protein, GST-tagged
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Cat.#:MAP3K14-1065HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAP3K14, GST-tagged
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Cat.#:MAP3K14-30381THTag:
Source (Host):Species:Human
Product nameRecombinant Human MAP3K14
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Cat.#:MAP3K14-556HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAP3K14, GST-tagged
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Cat.#:MAP3K14-2668RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAP3K14 Protein, His-tagged
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Cat.#:MAP3K14-2616CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAP3K14
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Cat.#:MAP3K14-4507HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAP3K14 293 Cell Lysate
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Involved Pathway

MAP3K14 involved in several pathways and played different roles in them. We selected most pathways MAP3K14 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PRKACBB; FGF6B; PAK2B; AKT3A; CDC42L; RPS6KA3; PPP3CC; PAK2; NLK; MAP2K7
NF-kappa B signaling pathway
LBP; TICAM2; VCAM1; PLAU; LAT; MAP3K14; PTGS2; TNFSF14; CCL19; RIPK1
Apoptosis
NFKB1; NFKBIAA; NFKBIAB; AKT2L; RIPK1L; PPP3R2; BIDA; FASLG; PIK3CA; BADB
Osteoclast differentiation
PPARG; IFNAR2; AKT2; SOCS1; SIRPA; MAP2K7; FOSL2; TYK2; LILRA5; OSCAR
T cell receptor signaling pathway
CD3E; CD8B; SHB; CBLC; MAPK9; VAV3; CBL; AKT2; IKBKG; IL5
TNF signaling pathway
Ccl12; MAPK1; MMP9; BIRC3; CX3CL1; PIK3R1; PIK3CA; IL15; TRAF1; MAPK8
Intestinal i
CCL25; MHC2DAB; IL5; AICDA; CCR10; Icosl; HLA-DMB; MHC2DEB; Il2; IL4
ne network for IgA production
BMA1; TNFSF13; CCL27B; TNFRSF17; HLA-DPB1; HLA-DQB1; H2-AA; HLA-DQA2; CD40LG; MHC2A
Epithelial cell signaling in Helicobacter pylori infection
MAPK13; PLCG1; NOD1; TJP1; ATP6V1B1; ATP6V1G1; ATP6AP1; CXCR2; SRC; ATP6V0A2
HTLV-I infection
CRTC2; CDC16; ITGAL; ATF1; IL15; VAC14; VCAM1; ANAPC7; TNF; FZD7
Epstein-Barr virus infection
PSMD13; TRAF5; HLA-DQA1; CD40; CD38; CR2; PIK3R3; POLR3K; MAP2K7; RIPK1

Protein Function

MAP3K14 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, MAP kinase kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K14 itself. We selected most functions MAP3K14 had, and list some proteins which have the same functions with MAP3K14. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KIF20A; PRPS2; TGFBR1; AXL; SMC5; DDX5; NTRK2; SBK3; CHKB; SLC14A2
Function MAP kinase kinase activity
Related Protein MAP2K6; LRRK2; MAPK10; SBK3; MAP2K7; MAP3K14; MAP2K2; MAPK14; MAP2K2A; MAP3K20
Function MAP kinase kinase kinase activity
Related Protein KIAA1804; BRAF; TAOK2; MAP3K4; MOS; MAP3K3; YSK4; STK4; MAP3K12; MAP3K8
Function NF-kappaB-inducing kinase activity
Related Protein PPP4C; ALPK2; IKBKE; IRAK1; ALK; RIPK3; MAP3K14
Function protein binding
Related Protein KDM5B; CPNE1; ATP6V1H; PSMA7; FAM83A; CRYBA4; MTMR7; TTLL6; EIF2S2; ZNF434
Function protein kinase activity
Related Protein KITB; CSNK1DB; GRK7A; MAPK8A; CHEK1; PRKCBA; RASSF2; PLK2B; RIPK4; SMOK2B
Function protein serine/threonine kinase activity
Related Protein PAK3; STK31; PRKD1; PRKCQ; TNIK; STK10; PRKCA; SNRKB; TTBK1; MAPK8

Interacting Protein

MAP3K14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K14.
CHUK; IKBKB; ALPL; HSP90AB1; CDC37; TRAF6