MCL1
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Official Full Name
myeloid cell leukemia sequence 1 (BCL2-related)
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Overview
MCL-1 (Myeloid cell leukemia-1) is a member of the BCL-2 family. The carboxy terminal of MCL-1 and BCL-2 share significant sequence homology. Expression of MCL-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in BCL-2. Like BCL-2, MCL-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis. This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. -
Synonyms
MCL1; myeloid cell leukemia sequence 1 (BCL2-related); induced myeloid leukemia cell differentiation protein Mcl-1; BCL2L3; Mcl 1; bcl-2-like protein 3; myeloid cell leukemia ES; bcl-2-related protein EAT/mcl1; TM; EAT; MCL1L; MCL1S; Mcl-1; MCL1-ES; bcl2-L-3; mcl1/EAT; MGC1839; MGC104264; myeloid cell leukemia sequence 1, isoform 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Felis catus (Cat) (Felis silvestris catus)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rhesus Macaque
- Rhesus monkey
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- MCL1 Related Articles
- MCL1 Related Gene Family
- MCL1 Related Signal Pathway
MCL1 involved in several pathways and played different roles in them. We selected most pathways MCL1 participated on our site, such as PIK-Akt signaling pathway, Jak-STAT signaling pathway, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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PIK-Akt signaling pathway | Itga10&Itgb1;PTK2;PPP2R2C;G6PC;RELA;GNB2;FGF3;COL4A1;FGF18 |
Jak-STAT signaling pathway | IFNA10;CRFB4;RAF1;IL28A;IL23;IFNA8;CNTFR;STAT5B;IL12RB2 |
MicroRNAs in cancer | Pdgfa&Pdgfb;FGFR3;NRAS;MMP16;PRKCG;SOS1;ZEB2;BMF;CDC25A |
MCL1 has several biochemical functions, for example, BH3 domain binding, protein binding, protein channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCL1 itself. We selected most functions MCL1 had, and list some proteins which have the same functions with MCL1. You can find most of the proteins on our site.
Function | Related Protein |
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BH3 domain binding | MCL1;BAX;BCL2L1;BCL2 |
protein binding | RCC2;KCNMB4;FSTL1;DRD4;UCHL1;UBE2O;ELL;SCAND1;ZEB1 |
protein channel activity | TIMM22;TOMM40;TOMM40L;TIMM23;MCL1 |
protein heterodimerization activity | BMP6;MAPK4;POU5F3;MEIS1;DRD1;MCL1A;HIST1H47;HIST1H2AA;ATF3 |
protein homodimerization activity | FGFR1OP2;TFRC;HLCS;AXIN1;RXRB;CHKA;GOT2;CARD9;DMRTC2 |
MCL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCL1.
BCL2L11; BAK1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, MCL1 modulation may have therapeutic implications in other diseases, such as neurodegenerative disorders, where apoptosis is a contributing factor.
Immunohistochemistry and molecular assays can be used to measure MCL1 expression levels, providing insights into the prognosis and potential treatment strategies.
Understanding MCL1 expression allows for the identification of patients who may benefit from targeted therapies, contributing to personalized treatment strategies.
Yes, there are several clinical trials investigating the use of MCL1 inhibitors in different cancer types to assess their safety and efficacy.
MCL1 interacts with pro-apoptotic and anti-apoptotic proteins in the Bcl-2 family, influencing the balance between cell survival and death.
Customer Reviews (3)
Write a reviewAnother advantage of using MCL1 protein in trials is its potential as a therapeutic agent.
The manufacturer's support and expertise further enhance the utility of MCL1 in my experimental work, ensuring reliable and high-quality results.
This collaborative partnership greatly contributes to the success of my research projects and facilitates meaningful contributions to the scientific community.
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