Recombinant Human Mcl1 (171-327) -delta(192-208) Protein

• Cat.No.: MCL135884H

Specification

• Description: Mcl1 (human) was expressed and purified from E. coli. The protein was expressed as a Nterminal HIS-fusion protein and purified by a 4-step chromatographic procedure comprising affinity, ion exchange and size exclusion chromatography steps including tag cleavage.
• Species: Human
• Molecular Mass: 18.1 kDa
• Purity: > 95%
• Storage: frozen; -80
• Storage Buffer: 20 mM TRIS 8.0;150 mM NaCl;2 mM DTT

Gene Information

• Gene Name: Mcl1 (171-327) -delta(192-208)
• Official Symbol: MCL1
• Synonyms: MDM2 Proto-Oncogene; MDM2 Proto-Oncogene; E3 Ubiquitin Protein Ligase; Oncoprotein Mdm2; Hdm2; Mdm2; Transformed 3T3 Cell Double Minute 2; P53 Binding Protein (Mouse); Mdm2; Transformed 3T3 Cell Double Minute 2; P53 Binding Protein; Mouse Double Minute 2; Human Homolog Of; P53-Binding Protein; Double Minute 2; Human Homolog Of; P53-Binding Protein; Mdm2; P53 E3 Ubiquitin Protein Ligase Homolog; MDM2 Oncogene; E3 Ubiquitin Protein Ligase
• Gene ID: 4170
• UniProt ID: Q07820

Reviews

06/20/2022

Another advantage of using MCL1 protein in trials is its potential as a therapeutic agent.

01/16/2022

The manufacturer's support and expertise further enhance the utility of MCL1 in my experimental work, ensuring reliable and high-quality results.

03/23/2016

This collaborative partnership greatly contributes to the success of my research projects and facilitates meaningful contributions to the scientific community.

Q&As

Can targeting MCL1 have implications beyond cancer therapy?

Yes, MCL1 modulation may have therapeutic implications in other diseases, such as neurodegenerative disorders, where apoptosis is a contributing factor.

Are there any diagnostic tools or biomarkers that can assess MCL1 expression in cancer patients?

Immunohistochemistry and molecular assays can be used to measure MCL1 expression levels, providing insights into the prognosis and potential treatment strategies.

How does the understanding of MCL1 function contribute to personalized medicine in cancer treatment?

Understanding MCL1 expression allows for the identification of patients who may benefit from targeted therapies, contributing to personalized treatment strategies.

Are there any ongoing clinical trials exploring MCL1 inhibitors as a therapeutic approach?

Yes, there are several clinical trials investigating the use of MCL1 inhibitors in different cancer types to assess their safety and efficacy.

How does the MCL1 protein interact with other proteins in the Bcl-2 family?

MCL1 interacts with pro-apoptotic and anti-apoptotic proteins in the Bcl-2 family, influencing the balance between cell survival and death.