Recombinant Human MCL1, GST-tagged

• Cat.No.: MCL1-782H
• Product Overview: Recombinant Human MCL1 was expressed as gst-tagged fusion protein by E.Coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-327aa
• Description: This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
• Storage: The protein is stored in PBS buffer at -20 oC. Repeated freeze-thaw cycles should be avoided.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: MCL1 myeloid cell leukemia sequence 1 (BCL2-related) [ Homo sapiens (human) ]
• Official Symbol: MCL1
• Synonyms: MCL1; TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT; myeloid cell leukemia sequence 1 (BCL2-related); induced myeloid leukemia cell differentiation protein Mcl-1; bcl-2-like protein 3; myeloid cell leukemia ES; bcl-2-related protein EAT/mcl1
• Gene ID: 4170
• mRNA Refseq: NM_021960
• Protein Refseq: NP_068779
• MIM: 159552
• UniProt ID: Q07820
• Chromosome Location: 1q21
• Pathway: Apoptosis Modulation and Signaling; Direct p53 effectors; HIF-1-alpha transcription factor network
• Function: BH3 domain binding; protein binding; protein channel activity