Recombinant Full Length Human MCL1 Protein, C-Flag-tagged

• Cat.No.: MCL1-337HFL
• Product Overview: Recombinant Full Length Human MCL1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 37.2 kDa
• AA Sequence: MFGLKRNAVIGLNLYCGGAGLGAGS GGATRPGGRLLATEKEASARREIGG GEAGAVIGGSAGASPPSTLT PDSRRVARPPPIGAEVPDVTATPAR LLFFAPTRRAAPLEEMEAPAADAIM SPEEELDGYEPEPLGKRPAV LPLLELVGESGNNTSTDGSLPSTPP PAEEEEDELYRQSLEIISRYLREQA TGAKDTKPMGRSGATSRKAL ETLRRVGDGVQRNHETAFQGMLRKL DIKNEDDVKSLSRVMIHVFSDGVTN WGRIVTLISFGAFVAKHLKT INQESCIEPLAESITDVLVRTKRDW LVKQRGWDGFVEFFHVEDLEGGIRN VLLAFAGVAGVGAGLAYLIRTRTRP LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane

Gene Information

• Gene Name: MCL1 MCL1 apoptosis regulator, BCL2 family member [ Homo sapiens (human) ]
• Official Symbol: MCL1
• Synonyms: TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT
• Gene ID: 4170
• mRNA Refseq: NM_021960.5
• Protein Refseq: NP_068779.1
• MIM: 159552
• UniProt ID: Q07820