nfkb1
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  • Official Full Name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • Background
  • This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • NFKB1; p50; KBF1; p105; EBP-1; MGC54151; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; DKFZp686C01211; nuclearfactor NF-kappa-Bp105subunit; NF-kappabeta; OTTHUMP00000161765; OTTHUMP00000216418; OTTHUMP00000219572; DNA binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit
Cat.#:NFKB1-105HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1
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Cat.#:NFKB1-120HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, T7/His-tagged
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Cat.#:NFKB1-1847HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His & GST-tagged
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Cat.#:NFKB1-300HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NFKB1 protein, MYC/DDK-tagged
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Cat.#:NFKB1-301HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His/T7-tagged
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Cat.#:NFKB1-30382THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFKB1
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Cat.#:NFKB1-30383THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFKB1
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Cat.#:NFKB1-309HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His/MBP-tagged
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Cat.#:NFKB1-310HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His/MBP-tagged
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Cat.#:NFKB1-633HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human NFKB1, His-tagged
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Cat.#:NFKB1-85HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFkB-p50 protein, active, GST-tagged
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Cat.#:NFKB1-10622MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NFKB1 Protein
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Cat.#:Nfkb1-1848MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nfkb1 protein, His & T7-tagged
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Cat.#:Nfkb1-1849RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nfkb1 protein, His & GST-tagged
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Cat.#:NFKB1-3015RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NFKB1 Protein, His-tagged
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Cat.#:NFKB1-1846CTag:His/T7
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken NFKB1 protein, His & T7-tagged
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Cat.#:NFKB1-6691CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NFKB1
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Cat.#:NFKB1-3850HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NFKB1 293 Cell Lysate
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Involved Pathway

NFKB1 involved in several pathways and played different roles in them. We selected most pathways NFKB1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP3K5; MAP2K2A; GRB2A; ZAK; RAF1A; Pdgfa&Pdgfb; PDGFRA; TNF; TGFB3; PDGFRB
Ras signaling pathway
GRIN2A; CALML3; FGF6; REL; PDGFC; PAK2; PLCG2; RAP1A; FGF14; PRKCG
cAMP signaling pathway
GPR119; SLC9A1; EP300; ATP1A3; HCAR2; PPP1CA; HCN4; GRIN1; ARAP3; PIK3R2
Chemokine signaling pathway
CCL22; Cxcl15; PIK3R3; CXCR1; ADRBK1; IL-8; GM2506; ROCK1; GNGT2; JAK2
NF-kappa B signaling pathway
LYN; LCK; LAT; TNFRSF1A; NFKB2; PRKCQ; TNFSF11; RIPK1; ICAM1; LBP
HIF- signaling pathway
FLT1; PIK3R1; AKT2; ENO1; PIK3CG; NFKB1; TCEB2; RPS6; SERPINE1; LDHA
Sphingolipid signaling pathway
PIK3CD; TRAF2; BCL2; PLCB2; SGMS1; MAPK11; BID; PPP2CB; ROCK1; PRKCZ
PIK-Akt signaling pathway
INSR; TNXB; PIK3R5; RPS6KB1; VEGFC; LAMB1; ITGAV; GNG3; ITGB5; PGF
Apoptosis
DBNLA; PRKAR2A; DNM1L; HDR; CASP6; IRF2A; CDKN2A; PRKACB; IRF4; BCL2L1
Osteoclast differentiation
FCGR1A; FOS; CSF1R; CSF1; TNFRSF1A; TRAF2; CYBB; BTK; PIK3R3; CALCR
Toll-like receptor signaling pathway
CXCL9; PIK3CB; IRAK1; TRAF6; CCL3L1; IFNA16; RIPK1; NFKB1; IFNA10; TLR2-1
NOD-like receptor signaling pathway
TAB2; NAIP6; BIRC3; IL8L1; HSP90AB1; Ccl12; CXCL2; MAPK14B; TAB3; NFKBIAA
RIG-I-like receptor signaling pathway
MAP3K1; MAPK12B; IL8L1; MAPK10; MAPK8; IFNA5; TBKBP1; IL12A; IKBKG; MAPK14A
Cytosolic DNA-sensing pathway
TMEM173; POLR3F; IL33; RELA; Ifna11; IFN-a; CCL4L2; POLR3D; POLR3B; IFNA13
T cell receptor signaling pathway
PAK3; CD247; MAP3K14; MAPK12; CD8B; PDCD1; FYN; DBNLB; PIK3R1; MAP2K7
B cell receptor signaling pathway
HRAS; STAP1; PLEKHA1; ITPR2; IKBKG; PPP3CC; PIK3R2; PLCG2; PIK3CA; CD19
TNF signaling pathway
CCL2; PIK3CB; CX3CL1; MAPK9; MLKL; ICAM1; TNFRSF1B; VEGFC; MAP2K7; AKT1
Neurotrophin signaling pathway
SH2B2; MAP2K2; NFKB1; SHC1; SHC4; MAP2K7; BDNF; GAB1; SH2B1; TRP53
Prolactin signaling pathway
SOCS4; GALT; SOCS5; PIK3CA; FOXO3; MAPK9; SHC3; GRB2; SHC2; SOCS3
Adipocytokine signaling pathway
CD36; RXRBA; ACSL4; AKT2L; G6PC; PRKAG1; G6PCA.1; TRADD; TNF; PRKAA2
Insulin resistance
PTPN11B; NFKBIAA; PPP1CC; PRKAG2A; PDPK1B; PPP1R3CB; PRKAG3B; MAPK8B; PTEN; RPS6KA2
Non-alcoholic fatty liver disease (NAFLD)
RAC1; COX6B2; IRS2; LEPR; NDUFS2; NDUFB11; NDUFB8; SDHC; IL6; COX8C
Cocaine addiction
PRKACA; FOSB; CREB5; NFKB1; CREB3L1; GRIN2C; DDC; RELA; GRIN2A; DRD1A
Epithelial cell signaling in Helicobacter pylori infection
JAM3; ATP6V0D1; MAPK10; ATP6V1G2; LYN; MAP3K14; NFKBIA; ATP6V1A; MAPK13; ATP6V1E2
Shigellosis
ROCK1; MAPK8; ABL1; ROCK2; WASF1; MAPK12; ATG5; ELMO3; ITGB1; RHOG
Salmonella infection
TLR4BA; CCL4L2; RHOGB; DYNC1I2A; MAPK11; DYNC1LI1; MAPK1; MAPK14B; ROCK1; WAS
Pertussis
RELA; ITGB2; FOS; RHOA; GM5077; MAPK3; C1S; C4BP; GNAI3; IL-8
Legionellosis
CASP1; SEC22B; CYCS; IL12B; CASP9; CR1; SAR1A; TLR5; SAR1B; IL6
Leishmaniasis
HLA-DQA2; STAT1; Itgam&Itgb2; PTPN6; NCF4; PRKCB; FCGR1A; IFNGR2; TNF; HLA-DRB3
Chagas disease (American trypanosomiasis)
MAPK3; CD247; TGFBR1; IRAK4; CFLAR; GNAI1; MAPK12; GNAQ; PIK3CA; PIK3R5
Toxoplasmosis
GNAI2; HSPA8; CASP9; H2-AB1; ITGB1; HSPA6; HLA-DQA2; TGFB2; MAPK10; IKBKG
Amoebiasis
ARG1; COL4A5; LAMC1; LAMA1; LAMC2; ITGB2L; IL1B2; COL1A1; GNAS; ARG2
Tuberculosis
HLA-DRB1; RFXAP; H2-AB1; TGFB2; IFNA8; ITGAM; Il23a; Il12b; Pla2r1; LSP1; HLA-DQB1
Hepatitis C
IKBKE; IFNA1; TRAF2; MAPK13; TRP53; CLDN23; CD81; NFKBIA; KRAS; EIF2AK2
Hepatitis B
IFNB1; TGFB3; TIRAP; TICAM2; CCND1; CCNE2; CREB3L3; PTEN; NFKBIA; DDX3X
Measles
CD3E; CD3D; TNFSF10; MAVS; SLAMF1; HSPA6; FYN; CLEC4M; TLR9; IL12B; IRAK1
Influenza A
Ccl12; IFNA16; FURIN; VDAC1; TBK1; PIK3R3; MAP2K4; PRSS1; TNFRSF1A; SOCS3
HTLV-I infection
HLA-DPB1; VDAC3; EGR2; TSPO; WNT7B; ZFP36; LTA; STAT5B; H2-AA; ATM
Herpes simplex infection
HLA-DQA1; IKBKE; CFP; TBP; HNRPK; IL12BA; ALYREF; IFNA13; IRF3; ABCB3L1
Epstein-Barr virus infection
STAT3; NFKBIE; TRAF5; PSMC5; TBP; SHFM1; POLR3H; PSMC3; GTF2E1; IL10RA
Pathways in cancer
PTGER1; PAX8; KRAS; CCNA1; Fzd4; RB1; EGLN2; GNB2; TRAF2; CTBP2
Transcriptional misregulation in cancer
SUPT3H; REL; PAX8; TGFBR2; NR4A3; SIN3A; ERG; Aff1; JMJD1C; HIST1H3A
Viral carcinogenesis
HRAS; LYN; MDM2; UBE3A; TTC6; IRF7; PIK3R5; H2-Q10; SKP2; PRKACG
MicroRNAs in cancer
BCL2; WNT3A; PIK3CA; MAP2K1; CDC25C; MDM4; CCND2; SLC7A1; PLCG2; ST14
Pancreatic cancer
ARAF; PIK3R1; RALGDS; STAT1; PIK3R2; BRAF; TRP53; TGFBR1; CCND1; SMAD2
Prostate cancer
INS; IKBKB; CREB3L2; SPINK1; MAPK3; HSP90AB1; MAPK1; PDGFD; RAF1; CPN1
Chronic myeloid leukemia
PIK3CD; STAT5B; CRKL; TGFB3; PIK3R1; RELA; BRAF; ARAF; AKT1; ABL1
Acute myeloid leukemia
BAD; NRAS; PIK3R5; PIK3R1; CHUK; MAPK3; LEF1; MAP2K2; PIK3CB; ZBTB16
Small cell lung cancer
CKS2; PIK3R3; LAMA1; BIRC3; PTGS2; PTK2; CCNE1; TP53; IKBKB; CCNE2
Inflammatory bowel disease (IBD)
HLA-DMA; STAT6; IL4; TLR4; FOXP3; SMAD3; IL18R1; IL21; IL12B; Il23a

Protein Function

NFKB1 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKB1 itself. We selected most functions NFKB1 had, and list some proteins which have the same functions with NFKB1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein POU4F1; H3F3A; NFATC1; NR1H4; NR5A2; RXRB; H3F3B; CDX1; ATF2; RUVBL2
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein HOXD9; DMRT1; ETV5; BARHL1B; H2AFY2; GLIS1; ZNF549; SP3; SNAI1; GATA4
Function actinin binding
Related Protein TTN; MICALL2; RELA; CSRP3; NFKB1; PKD2; PROM1; PDLIM5
Function chromatin binding
Related Protein RING1; POLG; PBX2; RNF20; POLR3D; HINFP; LHX2; NKX2; HOXD13; MB21D2
Function heat shock protein binding
Related Protein PARK2; PPP5C; DNAJA3A; DNAJA3; CDC37; NFKBIA; EEF1D; APAF1; PDXP; LIMK1
Function identical protein binding
Related Protein AGER; NFKB1; RAD52; CBX3; YWHAZ; PKD2L1; KCNJ10; SHANK3; DYNLT1F; CDC42
Function protein binding
Related Protein SERPINA1; PTPRR; TRIM35; PTGER4; TSPYL4; TMUB2; HOOK3; EIF6; GK; EPRS
Function protein heterodimerization activity
Related Protein NFE2L2A; ATF1; IKZF4; HIST1H4L; PDGFA; VAPA; HIST2H3C; TAS1R2; H2BFWT; SYT14
Function protein homodimerization activity
Related Protein TRIM8; IDE; UGT1A1; GPD1L; PEX11B; CHMP4B; MYH7; ADAM10; SIAH1A; HPGD
Function regulatory region DNA binding
Related Protein IRF5; IRF1B; HMGA2; IRF1A; IRF8; IRF3; IRF4A; IRF6; NFKB1; IRF2A
Function transcription factor activity, sequence-specific DNA binding
Related Protein SMAD6; NFIL3-4; ZSCAN16; VED; MESPBA; ZFP12; ZNF493; ZC3H8; CREBBP; ZNF549
Function transcription factor binding
Related Protein MYC; SMARCA4; CDKN2A; MED12L; NFATC2; SMARCD3; Trl; HDAC9; NKX3; NAB1
Function transcription regulatory region DNA binding
Related Protein Arid4b; ZFP639; SNCA; H2AFY2; RNF10; HIVEP2A; CREB3L1; NCOR1; CTCF; DDIT3
Function transcription regulatory region sequence-specific DNA binding
Related Protein SIN3A; SOX12; BACH1B; CRY2; PER2; SUV39H1; NFE2L2B; NFE2L1B; BAHD1; NR5A1B
Function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein SFPI1; FOXH1; SIX6; NFE2L2; PROP1; ARID3B; ZEB2; CDX1; SPI1; NFE2L1
Function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein BCL6; ZNF350; KLF12; VAX1; ZC3H8; SATB1; MITF; DMBX1; MSX1; ZBTB4

Interacting Protein

NFKB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKB1.
MAP3K8; RELA

NFKB1 Related Articles

Chen, Y; Lu, RQ; et al. The NFKB1 polymorphism (rs4648068) is associated with the cell proliferation and motility in gastric cancer. BMC GASTROENTEROLOGY 15:-(2015).
Jacque, E; Schweighoffer, E; et al. IKK-induced NF-kappa B1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. JOURNAL OF EXPERIMENTAL MEDICINE 211:2085-2101(2014).