nfkb1
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  • Official Full Name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • Background
  • This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • NFKB1; p50; KBF1; p105; EBP-1; MGC54151; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; DKFZp686C01211; nuclearfactor NF-kappa-Bp105subunit; NF-kappabeta; OTTHUMP00000161765; OTTHUMP00000216418; OTTHUMP00000219572; DNA binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit
Cat.#:NFKB1-105HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1
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Cat.#:NFKB1-120HTag:T7|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, T7/His-tagged
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Cat.#:NFKB1-1847HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His & GST-tagged
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Cat.#:NFKB1-300HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NFKB1 protein, MYC/DDK-tagged
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Cat.#:NFKB1-301HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His/T7-tagged
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Cat.#:NFKB1-30382THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFKB1
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Cat.#:NFKB1-30383THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFKB1
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Cat.#:NFKB1-309HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His/MBP-tagged
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Cat.#:NFKB1-310HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His/MBP-tagged
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Cat.#:NFKB1-633HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human NFKB1, His-tagged
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Cat.#:NFKB1-85HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFkB-p50 protein, active, GST-tagged
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Cat.#:NFKB1-10622MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NFKB1 Protein
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Cat.#:Nfkb1-1848MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nfkb1 protein, His & T7-tagged
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Cat.#:Nfkb1-1849RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nfkb1 protein, His & GST-tagged
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Cat.#:NFKB1-3015RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NFKB1 Protein, His-tagged
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Cat.#:NFKB1-1846CTag:His|T7
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken NFKB1 protein, His & T7-tagged
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Cat.#:NFKB1-6691CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NFKB1
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Cat.#:NFKB1-3850HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human NFKB1 293 Cell Lysate
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Involved Pathway

NFKB1 involved in several pathways and played different roles in them. We selected most pathways NFKB1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PAK2A; NGF; MAP3K3; TGFBR1; MRAS; CACNG2A; PTPRR; SRFA; TRP53; MAPK1
Ras signaling pathway
INSR; FOXO4; RGL2; NGF; CSF1; FGF7; GNG12; ARF6; FGF11; PIK3CB
cAMP signaling pathway
CNGA3; GRIN1; FSHR; CAMK2G; NFKB1; PIK3CD; HTR1F; ATP1B4; PPARA; LIPE
Chemokine signaling pathway
CXCR1; CCL14; VAV3; CCL2; Ccl12; CCL5; Cxcl15; CXCL16; KRAS; GNG7
NF-kappa B signaling pathway
IL1R1; TRIM25; ZAP70; CXCL12; ICAM1; MYD88; NFKBIA; TRAF1; ERC1; GADD45B
HIF- signaling pathway
HK2; STAT3; ANGPT2; TCEB1; PDHB; RPS6KB1; ANGPT4; EPO; CUL2; BCL2
Sphingolipid signaling pathway
PPP2R3C; BDKRB2; PLCB3; FCER1G; RAC2; CERS2; NFKB1; GNAI3; MS4A2; TRADD
PIK-Akt signaling pathway
YWHAZ; FGF22; IL7; FGF14; ITGA10; PCK2; GNG11; ATF4; CRTC2; THBS1
Apoptosis
PANK1A; RELA; IRAK3; PRKAR2AA; PRKAR1B; DYNLL2; RIPK1; DIABLOB; NFKB1; CDKN2A
Osteoclast differentiation
TRAF6; IFNGR1; MAPK8; CYBB; TEC; FCGR1; SIRP-BETA; PPP3CA; PIK3CB; IL1A
Toll-like receptor signaling pathway
PIK3R3; MAP2K7; CD86; IL12A; IKBKB; PIK3CG; RIPK1L; TLR7; CXCL11; CCL4L1
NOD-like receptor signaling pathway
PSTPIP1A; CARD8; HSP90AA1.1; MAPK8A; NLRP3; TNFAIP3; BIRC2; NLRC4; PSTPIP1B; PYCARD
RIG-I-like receptor signaling pathway
DAK; TBKBP1; IFNK; IKBKB; RNF125; TBK1; MAPK12A; Ifna15; IFNA7; IL12B
Cytosolic DNA-sensing pathway
NFKBIAB; CXCL10; CCL5; IFNPHI1; POLR3G; TMEM173; IFNA14; CCL4L2; IFNA12; NFKB1
T cell receptor signaling pathway
PPP3CB; Il2; CBL; CD247; PIK3CD; FOS; RAF1; PIK3CA; AKT2; VAV1
B cell receptor signaling pathway
RAC3; BANK1; CR2; DOK1B; CRKL; SOS1; GSK3AB; PPP3CB; IKBKG; NFATC1
TNF signaling pathway
MLKL; CFLAR; PGAM5; NFKBIA; NFKB1; IL6; CCL5; MMP9; AKT2; MMP14
Neurotrophin signaling pathway
CAMK2B; NFKBIB; CALM1; CALM3; RELA; Fasl; MAPK8; RAP1B; TRP53; SHC2
Prolactin signaling pathway
NRAS; AKT1; SIRPA; TH; MAP2K1; SHC3; SLC2A2; SOCS6; PIK3CD; GALT
Adipocytokine signaling pathway
LEP; SLC2A4; LEPR; PRKAB2; SOCS3; G6PC; RXRA; LEPA; PPARGC1A; TRAF2
Insulin resistance
PCK2; PIK3R5; PRKCZ; PRKAA1; CREB3L1; PRKAG2; GFPT2; PIK3R3B; PPP1R3B; PPP1CA
Non-alcoholic fatty liver disease (NAFLD)
CASP8; NDUFC1; MAP3K11; PIK3R5; COX6B2; PIK3CB; NDUFV2; NDUFA2; COX7B; Fasl
Cocaine addiction
MAOB; NFKB1; PDYN; CREB3L1; CREB3L4; GRM2; BDNF; CREB3L3; CREB3; FOSB
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1B1; ATP6V1G3; ATP6V0D1; MAPK8; MAPK12; ATP6V0A4; ATP6V1A; CXCR1; CXCR2; MAPK11
Shigellosis
ELMO3; MAPK3; ELMO2; UBE2D2; RELA; MAPK10; IKBKG; DIAPH1; ROCK1; ACTB
Salmonella infection
MAPK3; RAB7B; PFN2; MAPK8; CXCL2; WASLB; MAPK12; RAC1B; ROCK2A; DYNC1I2A
Pertussis
IRF1; C3; IL6; CALM1; IL-8; TNF; CXCL5; IRF3; CASP7; TICAM2
Legionellosis
SEC22B; ITGAM; CASP1; HBS1L; APAF1; CXCL1; NFKB1; EEF1G; Casp3; EEF1A1
Leishmaniasis
FOS; FCGR2C; FCGR3A; HLA-DQA1; FCGR3; NFKBIA; TLR4; FCGR3B; IL1B; TNF
Chagas disease (American trypanosomiasis)
C1QA; C3; MAPK9; TRAF6; CD3G; TLR6; CCL3L3; PIK3CB; TLR2; CCL3L1
Toxoplasmosis
IL12B; ALOX5; HSPA1L; TGFB3; LAMB3; LAMA2; MAP3K7; TGFB1; AKT1; BIRC2
Amoebiasis
RAB7; ARG2; PIK3CD; CXCL8; COL4A6; GNA15; NFKB1; SERPINB3; CXCL1; ACTN4
Tuberculosis
CLEC4M; C3; MAPK9; HLA-DPB1; TLR4; FCGR3; ITGAX; RIPK2; CLEC4E; IFNA10
Hepatitis C
RIPK1; IFNA17; KRAS; PIK3R5; IFNA8; TYK2; MAPK11; EIF2AK1; PIK3CB; CXCL8
Hepatitis B
PIK3CB; ATP6AP1; RAF1; AKT1; CASP9; TLR3; CXCL8; CREB3L2; ELK1; YWHAZ
Measles
PIK3CB; TP53; MSN; DOK1; TNFRSF10C; PIK3R2; CCND2; IL1A; IFNA16; FAS
Influenza A
RAE1; MAPK1; TLR3; PIK3CB; IL12A; ADAR; IKBKB; HLA-DPA1; MAP2K7; TNFRSF1A
HTLV-I infection
FDPS; PRKACA; CD40; HLA-DRB3; PIK3CD; Fzd4; HRAS; HLA-G; PCNA; IL2RA
Herpes simplex infection
JAK2B; TYK2; IKBKE; CASP8; FB06F03; PVRL1; MAPK8; HNRPKL; IRF3; TRAF1
Epstein-Barr virus infection
SFPI1; MAP3K14; HLA-F; POLR2C; PIK3R5; NFKBIA; IFNG; PSMC6; RBPJL; CD44
Pathways in cancer
GNG5; FASLG; FLT3LG; ITGAV; FH; RHOA; HGF; TRAF1; GRB2; MET
Transcriptional misregulation in cancer
ETV6; BMP2K; FCGR1A; LRP2BP; ZBTB17; BCL2L1; HOXA11; MDM2; Bcl2a1b; RUNX1T1
Viral carcinogenesis
DDX3X; HIST1H4K; RBPJL; SRF; STAT5B; LTBR; TRADD; GTF2A2; MAPK1; H2-Q10
MicroRNAs in cancer
ATM; WNT3A; MMP16; IRS1; FGFR3; GLS; CDC25B; CD44; MAPK7; MTOR
Pancreatic cancer
PIK3R1; PIK3R3; MAP2K1; SMAD4; MAPK3; STAT3; ARHGEF6; PLD1; ARAF; TGFB1
Prostate cancer
PDGFB; CREB3L3; TCF7; NDRG1; SRD5A2; PDGFRA; Ar; AKT2; TCF7L2; PDPK1
Chronic myeloid leukemia
PIK3R5; TP53; MAP2K1; SHC1; RUNX1; AKT1; RB1; STAT5A; GAB2; PTPN11
Acute myeloid leukemia
RUNX1; BAD; MAP2K2; JUP; RAF1; PIK3R2; FLT3; PIK3R5; CEBPA; PIK3CG
Small cell lung cancer
ITGA3; LAMB4; IKBKG; IKBKB; BIRC3; LAMA5; COL4A1; LAMC2; PTEN; CCND1
Inflammatory bowel disease (IBD)
HLA-DPA1; H2-AB1; HLA-DRB3; IL18; Il23a; IL12RB1; IL21; RORA; IL12A; RELA

Protein Function

NFKB1 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKB1 itself. We selected most functions NFKB1 had, and list some proteins which have the same functions with NFKB1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein POU4F1; REL; FLI1; H3F3A; SOX10; NR2F6; NONO; GZF1; NR1H4; NFE2L2
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein IKZF3; ZNF8; SOX13; PHF21B; GATA4; TRPS1; CUX2; GATA2; CGGBP1; BCL6AB
Function actinin binding
Related Protein CSRP3; PKD2; NFKB1; MICALL2; PDLIM5; TTN; PROM1; RELA
Function chromatin binding
Related Protein PHC1; HMGB3B; TMPOA; TCF7L1A; WDHD1; POU1F1; ARID5A; HMGB2B; DHX30; MEF2A
Function heat shock protein binding
Related Protein DNAJA2; SSUH2RS1; NFKBIA; CDC37L1; HSPA1L; DNAJA3; HSPA1A; DNAJC9; LIMK1; EEF1D
Function identical protein binding
Related Protein EGFR; C14orf166; GBP5; CLDN10; GOT1; CASP6; LRRK1; CLDN15; S100B; CNTN2
Function protein binding
Related Protein CD163; ITPR1; ATF2; TTYH2; KIR2DL1; EEF1A2; SLC25A6; CBLN3; AIM2; SERTAD1
Function protein heterodimerization activity
Related Protein SOX6; HIST1H2AA; HIST1H4A; HER5; HEXB; HIST3H2BB; HNF1B; TBX15; HIST2H2AA4; UBXN6
Function protein homodimerization activity
Related Protein LDB1; BAX; DMRTC1B; ALDH5A1; UGT1A3; AADAT; MYH7; ASMT; ACOT7; TERF1
Function regulatory region DNA binding
Related Protein IRF1A; NFKB1; IRF2A; IRF3; IRF5; HMGA2; IRF4A; IRF8; IRF6; IRF1B
Function transcription factor activity, sequence-specific DNA binding
Related Protein FOXI3A; AHCTF1; TEFB; GATA2B; RORCB; PRDM15; STAT5A; ZNF584; ZNF615; PPARA
Function transcription factor binding
Related Protein GATA6; MED25; MAFB; RB1; PSMD4; PIAS1; SORBS3; PBX1; CDKN2A; PSMC5
Function transcription regulatory region DNA binding
Related Protein TBX21; TOMM20A; SOX6; CREB3L1; GABPA; XRCC5; FOXA2; BCOR; XBP1; ZBTB14
Function transcription regulatory region sequence-specific DNA binding
Related Protein MEF2CA; BACH1B; NR5A1B; CREB3L3; NR5A5; MEF2AA; POU2F1; PSPC1; NFE2; HIF1AL
Function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein BACH1; PBX3; NFE2L2; SIX3; SPI1; MIXL1; RELA; HMGA1; MEOX2; HCFC1
Function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein NFKB1; SATB1; ETV3; CGGBP1; FERD3L; BCL6A; CSDA; FOXD3; VAX1; ZBTB4

Interacting Protein

NFKB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKB1.
MAP3K8; RELA

NFKB1 Related Articles

Chen, Y; Lu, RQ; et al. The NFKB1 polymorphism (rs4648068) is associated with the cell proliferation and motility in gastric cancer. BMC GASTROENTEROLOGY 15:-(2015).
Jacque, E; Schweighoffer, E; et al. IKK-induced NF-kappa B1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. JOURNAL OF EXPERIMENTAL MEDICINE 211:2085-2101(2014).