nfkb1
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  • Official Full Name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • Background
  • This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • NFKB1; p50; KBF1; p105; EBP-1; MGC54151; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; DKFZp686C01211; nuclearfactor NF-kappa-Bp105subunit; NF-kappabeta; OTTHUMP00000161765; OTTHUMP00000216418; OTTHUMP00000219572; DNA binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit
Cat.#:NFKB1-105HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1
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Cat.#:NFKB1-120HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, T7/His-tagged
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Cat.#:NFKB1-1847HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His & GST-tagged
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Cat.#:NFKB1-300HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NFKB1 protein, MYC/DDK-tagged
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Cat.#:NFKB1-301HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His/T7-tagged
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Cat.#:NFKB1-30382THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFKB1
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Cat.#:NFKB1-30383THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFKB1
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Cat.#:NFKB1-309HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His/MBP-tagged
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Cat.#:NFKB1-310HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His/MBP-tagged
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Cat.#:NFKB1-633HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human NFKB1, His-tagged
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Cat.#:NFKB1-85HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFkB-p50 protein, active, GST-tagged
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Cat.#:NFKB1-10622MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NFKB1 Protein
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Cat.#:Nfkb1-1848MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nfkb1 protein, His & T7-tagged
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Cat.#:Nfkb1-1849RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nfkb1 protein, His & GST-tagged
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Cat.#:NFKB1-3015RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NFKB1 Protein, His-tagged
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Cat.#:NFKB1-1846CTag:His/T7
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken NFKB1 protein, His & T7-tagged
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Cat.#:NFKB1-6691CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NFKB1
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Cat.#:NFKB1-3850HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NFKB1 293 Cell Lysate
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Involved Pathway

NFKB1 involved in several pathways and played different roles in them. We selected most pathways NFKB1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF6; HSP70; RASGRP3; CACNB3A; PLA2G4D; RPS6KA2; MKNK2; MKNK2A; ATF4; CD14
Ras signaling pathway
VEGFB; PLA2G4F; RAP1B; PLA2G2E; CALM2; ZAP70; RASSF1; FGF10; RAC3; Kitl
cAMP signaling pathway
PTGER2; CNGA3; ORAI1; HCN2; CALM1; PPP1CA; FFAR2; PPARA; PIK3CB; ROCK1
Chemokine signaling pathway
CCL3L1; CCR8; GNG12; PF4; CCL21B; RELA; GRK7; RLN1; CCL28; GNG10
NF-kappa B signaling pathway
LBP; IKBKB; SYK; CCL4L2; PLCG2; ERC1; GM13304; TRAF2; TRAF6; CD40
HIF- signaling pathway
IFNGR1; PIK3CD; PIK3R3; PLCG1; CAMK2G; MAP2K1; TCEB1; GAPDH; NOX3; ALDOA
Sphingolipid signaling pathway
PIK3CG; BCL2; PPP2CB; PPP2R5C; PPP2R1A; ACER1; PLD1; KRAS; RAC3; MAP2K2
PIK-Akt signaling pathway
CD19; IKBKB; PCK1; PIK3R5; PDPK1; IFNA16; ITGB1; YWHAG; KITLG; IFNA6
Apoptosis
DSP; CAPN1A; IL1R1; OCLN; Casp3; CLSPN; PPP3R2; IRF4; RNF8; DIABLOB
Osteoclast differentiation
TEC; SIRPB1; PPP3R1; FCGR4; IKBKG; PIK3CB; RAC1; IFNG; LILRB4; PLCG2
Toll-like receptor signaling pathway
IKBKG; TNF; STAT1A; NFKBIAA; TLR5; IFNPHI1; TLR2-2; IFNA17; IFNA5; IKBKE
NOD-like receptor signaling pathway
NFKBIAB; MAPK10; CARD18; CCL2; CASP5; TRIP6; PYCARD; MAPK12A; MAP3K7; RIPK2
RIG-I-like receptor signaling pathway
IFNA14; RIPK1L; ATG12; RNF125; DAK; IFNA16; DDX3; PL10; TANK; TRAF3
Cytosolic DNA-sensing pathway
POLR3GLB; POLR3F; TMEM173; POLR2F; IFNA21; IFNA12; NFKBIA; MB21D1; POLR2K; IFNA3
T cell receptor signaling pathway
MAP2K2; IL5; PRKCQ; PAK3; NFKBIB; OXSR1A; SHB; MAPK11; VAV3; PIK3R3
B cell receptor signaling pathway
CSK; BTK; SOS1; PRKCB; PIK3AP1; PIK3CB; DOK1; PIK3R1; BLK; CD81
TNF signaling pathway
VEGFC; BIRC3; SELE; CXCL10; PIK3CG; CREB3L3; CREB3L1; TRADD; BAG4; TNFRSF1B
Neurotrophin signaling pathway
NTF4; RPS6KA5; CALM1; PIK3CD; BAD; NGF; NTRK1; NTF3; PIK3CG; ZNF274
Prolactin signaling pathway
PIK3R2; SHC1; NRAS; SHC4; KRAS; PIK3CB; STAT3; PIK3CD; NEK3; ELF5
Adipocytokine signaling pathway
POMC; ACSL1B; PCK1; ACSL4A; TRAF2; ADIPOR1B; RXRGB; STK11; PRKAG3; ACSL3B
Insulin resistance
PIK3CG; PPP1CA; GFPT2; NFKB1; CREB1A; NFKBIA; INSRA; PRKCE; MAPK8; PIK3R3
Non-alcoholic fatty liver disease (NAFLD)
NDUFA5; MAPK9; COX8C; PIK3CG; NDUFA11; NDUFB9; AKT1; IL6R; ERN1; ITCH
Cocaine addiction
CREB3L3; DRD1; GPSM1; GNAI2; CDK5; DRD2; GRIN1; BDNF; ATF6B; TH
Epithelial cell signaling in Helicobacter pylori infection
ATP6V0D2; TCIRG1; ATP6V0A4; ATP6V1F; MAPK9; ATP6V0D1; CDC42; ATP6V1G1; ATP6V1C1; PTPN11
Shigellosis
RELA; NFKB1; RHOG; ROCK2; MAPK10; ACTG1; MAPK8; DIAPH1; CD44; ITGA5
Salmonella infection
WASF1; CASP1; TLR4; DYNC1LI2; ROCK1; MAPK12B; RAC1A; CCL3L3; MAPK11; MAPK8
Pertussis
IRF1; IL23; ITGA5; CASP1; C4BP; C1RA; MAPK13; C1QB; Itgam&Itgb2; C1QC
Legionellosis
CXCL3; Itgam&Itgb2; TLR2; HSPA1B; NAIP7; RELA; NLRC4; NFKB1; NFKB2; HSPA6
Leishmaniasis
PRKCB; TGFB3; HLA-DQB1; HLA-DOB; MARCKSL1; IRAK1; H2-AA; TRAF6; NCF2; STAT1
Chagas disease (American trypanosomiasis)
CALR; TLR2; PIK3R1; Fasl; PPP2R2C; PPP2CB; IRAK1; PIK3R2; SMAD3; IKBKG
Toxoplasmosis
GNAI2; HLA-DPB1; Toxoplasma Gondii Microneme Protein MIC3; NFKB1; Toxoplasma Gondii Profilin Family Protein; LAMA1; CASP8; TLR2; TLR4; HLA-DRB3
Amoebiasis
COL2A1; COL5A2; ARG2; PIK3CG; LAMB2; COL4A6; PLCB4; TGFB1; MUC2; COL1A1
Tuberculosis
IL1A; RAF1; HLA-DQA1; MAPK12; IL18; HLA-DOA; IL10RA; H2-AA; CYCS; NFYB
Hepatitis C
IKBKE; CLDN1; BAD; PPP2R2C; PIK3CD; CLDN8; OAS2; TNFRSF1A; TRADD; MAPK12
Hepatitis B
Ifna15; Casp3; CREB3L3; IFNA16; SRC; CCNA1; PIK3R3; TGFB3; STAT2; BAX
Measles
TP53; CCND2; TLR2; IFNA6; FYN; PIK3CG; AKT2; CD28; DOK1; NFKBIA
Influenza A
TRIM25; FURIN; NUP98; RNASEL; IFNA10; PRSS1; SLC25A6; IFNA2; PIK3CA; PABPN1
HTLV-I infection
TNF; WNT1; GM-CSF; CRTC1; SRF; HLA-C; CREM; MSX1; WNT5B; NFKBIA
Herpes simplex infection
PER1; IFNA3; EP300; TAP1; HLA-DPA1; TRP53; IFNA1; MAP3K7; STAT1A; TBK1
Epstein-Barr virus infection
NFKBIE; CCNA2; PSMC4; PSMD4; HLA-DQA2; POLR2I; EIF2AK1; PSMD2; MDM2; PIK3CB
Pathways in cancer
GLI3; IL-8; CBL; PIAS2; WNT2B; LAMA2; AGTR1B; RUNX1; TCEB2; RXRB
Transcriptional misregulation in cancer
IL-8; MMP3; ETV4; PAX7; MET; TSPAN7; SS18; MLL1; TAF15; BCL2L1
Viral carcinogenesis
HDAC9; HIST1H2BQ; SND1; PKM; DLG1; HLA-B; SRF; Casp3; HIST1H2BJ; SCIN
MicroRNAs in cancer
CCND1; PRKCA; MAP2K2; MMP9; WNT3A; TRP63; SPRY2; ROCK1; TGFB2; PDGFRB
Pancreatic cancer
PLD1; TGFBR2; PIK3R5; RALB; SMAD3; TGFBR1; BCL2L1; PIK3R2; ARHGEF6; BAD
Prostate cancer
ERBB2; GRB2; PDGFD; SMARCA4; CREB5; PIK3CD; CREB3L1; CCNE2; AKT1; INS1
Chronic myeloid leukemia
HRAS; RELA; MECOM; CBLB; SHC2; TGFB2; TGFB1; MAP2K1; PIK3CB; CCND1
Acute myeloid leukemia
ZBTB16; PIK3R5; SOS1; RELA; GRB2; AKT1; PIK3R3; MYC; PIK3CG; STAT5A
Small cell lung cancer
ITGA3; AKT2; FN1; NOS2; XIAP; CASP9; NFKBIA; TRAF6; FHIT; LAMA3
Inflammatory bowel disease (IBD)
Il2; IL18R1; IL18; TGFB1; TBX21; TNF; IFNGR2; Il4ra; H2-AB1; HLA-DQA2

Protein Function

NFKB1 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKB1 itself. We selected most functions NFKB1 had, and list some proteins which have the same functions with NFKB1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein CDX1; CDX2; FLI1; PAX4; CREB1; BACH1; SFPI1; NFKB1; NFATC1; JUN
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein ZNF773; ETV7; IKZF5; HOXD8; SP5; ZNF691; H2AFY2; MYOG; PHOX2B; SKINT8
Function actinin binding
Related Protein RELA; TTN; PROM1; PDLIM5; PKD2; CSRP3; NFKB1; MICALL2
Function chromatin binding
Related Protein TPR; HDGF2; SUV39H1; TP73; NR5A5; CBX5; SMARCD1; TLE1; UBE2T; MEIS1
Function heat shock protein binding
Related Protein DNAJC9; DAXX; BAX; DNAJB6; DNAJC7; CDC37; DNAJA2; NFKB1; HSPA1B; SSUH2RS1
Function identical protein binding
Related Protein BRI3; ALK; UAP1; RASSF1; PYDC3; S100A2; EPHA4; INS; GAPDH; PRKAB2
Function protein binding
Related Protein CCNDBP1; HNRPLL; INPP4B; ASH2L; RYR1; EPB41B; CTTN; INPP5D; SNAI1; AGPAT4
Function protein heterodimerization activity
Related Protein IKZF2; THRA; HOMER2; KCNN1; MICU1; PDGFB; HIST1H47; PVRL1; APOA2; F11R.1
Function protein homodimerization activity
Related Protein SDCBP2; GSTZ1; MYH7; S100A16; TESCA; FAP; ZNF174; CITED1; IL6ST; SLC51A
Function regulatory region DNA binding
Related Protein IRF1B; IRF1A; IRF4A; HMGA2; IRF5; IRF8; IRF6; IRF2A; IRF3; NFKB1
Function transcription factor activity, sequence-specific DNA binding
Related Protein PBX3B; FOXB1A; NTNG1; HIC1; KAT7B; POU6F2; TCF7L1B; ZNF483; RCAN1; ELF1
Function transcription factor binding
Related Protein HDAC1; SUFU; MYBBP1A; PARP1; HDAC2; JUNBB; HDAC5; AIP; TFDP1B; FOSB
Function transcription regulatory region DNA binding
Related Protein GATA5; PRDM5; XRCC5; TBX21; HHEX; TBL1XR1; MTERFD3; NFE2L2; SALL2; CTCFL
Function transcription regulatory region sequence-specific DNA binding
Related Protein SOX11; SOX2; NFKB1; SOX12; ARNTL1A; MKL1; NR5A1A; DDIT3; NKX3-1; NR5A2
Function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein FOXH1; MIXL1; TARDBP; PROP1; CDX1; HMGA1; RELA; MEOX2; PBX3; HOXB5
Function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein ZNF350; BCL6A; ETV3; NR2F6; VAX1; ZBTB4; E4F1; CSDA; MITF; ETV7

Interacting Protein

NFKB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKB1.
MAP3K8; RELA

NFKB1 Related Articles

Chen, Y; Lu, RQ; et al. The NFKB1 polymorphism (rs4648068) is associated with the cell proliferation and motility in gastric cancer. BMC GASTROENTEROLOGY 15:-(2015).
Jacque, E; Schweighoffer, E; et al. IKK-induced NF-kappa B1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. JOURNAL OF EXPERIMENTAL MEDICINE 211:2085-2101(2014).