nfkb1
Share
  • Official Full Name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • Background
  • This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • NFKB1; p50; KBF1; p105; EBP-1; MGC54151; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; DKFZp686C01211; nuclearfactor NF-kappa-Bp105subunit; NF-kappabeta; OTTHUMP00000161765; OTTHUMP00000216418; OTTHUMP00000219572; DNA binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit
Cat.#:NFKB1-105HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1
+Inquiry
Cat.#:NFKB1-120HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, T7/His-tagged
+Inquiry
Cat.#:NFKB1-1847HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His & GST-tagged
+Inquiry
Cat.#:NFKB1-300HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NFKB1 protein, MYC/DDK-tagged
+Inquiry
Cat.#:NFKB1-301HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His/T7-tagged
+Inquiry
Cat.#:NFKB1-30382THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFKB1
+Inquiry
Cat.#:NFKB1-30383THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFKB1
+Inquiry
Cat.#:NFKB1-309HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His/MBP-tagged
+Inquiry
Cat.#:NFKB1-310HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB1 protein, His/MBP-tagged
+Inquiry
Cat.#:NFKB1-633HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human NFKB1, His-tagged
+Inquiry
Cat.#:NFKB1-85HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFkB-p50 protein, active, GST-tagged
+Inquiry
Cat.#:NFKB1-10622MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NFKB1 Protein
+Inquiry
Cat.#:Nfkb1-1848MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nfkb1 protein, His & T7-tagged
+Inquiry
Cat.#:Nfkb1-1849RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nfkb1 protein, His & GST-tagged
+Inquiry
Cat.#:NFKB1-3015RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NFKB1 Protein, His-tagged
+Inquiry
Cat.#:NFKB1-1846CTag:His/T7
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken NFKB1 protein, His & T7-tagged
+Inquiry
Cat.#:NFKB1-6691CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NFKB1
+Inquiry
Cat.#:NFKB1-3850HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NFKB1 293 Cell Lysate
+Inquiry

Involved Pathway

NFKB1 involved in several pathways and played different roles in them. We selected most pathways NFKB1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PDGFRB; MAP2K4; MAP4K2; PPP3CCA; MAPK8IP3; TGFB1; HSPA6; CDC25B; MAPK8IP2; BDNF
Ras signaling pathway
GNB3; PIK3R2; INS2; GRIN2A; FGFR3; RASSF5; FGF5; FGF1; KSR2; BAD
cAMP signaling pathway
PPARA; ROCK2; PDE3B; PPP1R12A; TSHR; RHOA; HTR1F; PIK3R2; PLD2; MLLT4
Chemokine signaling pathway
ELMO1; MAPK3; PIK3R5; ARRB2; IL-8; CXCL1; GRB2; FGR; GNG12; CCL3L3
NF-kappa B signaling pathway
MAP3K7; LBP; TNFRSF11A; CCL4L1; SYK; PIAS4; CCL21; Ccl21c; VCAM1; BCL2
HIF- signaling pathway
TFRC; TF; PDHA1; PIK3R5; ARNT; RBX1; PDHB; PIK3R1; RPS6KB2; ENO1
Sphingolipid signaling pathway
AKT1; LOC100328615; MAPK8; ASAH2; GAB2; LASS5; DEGS2; SGMS1; ASAH1; PRKCA
PIK-Akt signaling pathway
TNN; IFNA4; G6PC; PIK3R5; PDPK1; GNG10; YWHAE; PIK3R2; IFNA10; ITGB5
Apoptosis
BCL2A; CFLAR; HRK; CASP6; AKT3A; CLSPN; H1F0; PRKAR1AB; CAPN1B; TICAM1
Osteoclast differentiation
NFKB2; MAPK8; ITGB3; LILRB2; TNFRSF1A; LILRB5; TGFB2; SYK; PIK3CD; MAPK3
Toll-like receptor signaling pathway
TLR3; MAPK10; IL1B; TICAM2; CD14; TNF; TLR2; STAT1; IFNPHI1; AKT3A
NOD-like receptor signaling pathway
RIPK2; NLRC4; CARD9; TNF; HSP90AA1.2; ERBB2IP; NLRP3; HSP90AB1; PYDC1; HSP90AA1
RIG-I-like receptor signaling pathway
CASP8; MAPK9; MAPK13; IFNW1; OTUD5; CASP10; ISG15; IFNA17; IFNA1; IFNA21
Cytosolic DNA-sensing pathway
IFNA12; IFNPHI1; IFNA1; IRF7; IFNA21; NFKBIA; POLR3F; POLR2F; IFNB; CCL4L2
T cell receptor signaling pathway
NFATC1; KRAS; NFKB1; MAPK12; CD4; MUC1; MAP3K14; HRAS; PAK2; NFKBIA
B cell receptor signaling pathway
CRKL; AKT1; SOS1; HDAC5; PDPK1A; cgr2b; DUSP6; PDK2; BTK; CR2
TNF signaling pathway
BCL3; IKBKB; CXCL1; VCAM1; TNFRSF1B; TRADD; TRAF2; MAPK8; CXCL2; MAPK1
Neurotrophin signaling pathway
NTF3; BDNF; NGFRAP1; RHOA; MAPK8; SHC4; MAP2K5; TRP53; ABL1; IRAK2
Prolactin signaling pathway
GALT; PIK3CD; IRF1; SLC2A2; CSH; TNFRSF11A; GSK3B; MAPK11; TH; MAP2K1
Adipocytokine signaling pathway
PCK2; LEPA; ADIPOR2; CAMKK1; LEPR; G6PCA.2; CAMKK1A; G6PCA.1; RELA; RXRGA
Insulin resistance
SLC2A1; PPP1CBL; PIK3CD; PPP1R3D; OGT.1; PPARGC1B; PYGB; SLC2A2; FOXO1; GSK3B
Non-alcoholic fatty liver disease (NAFLD)
NDUFB11; COX6A2; MLXIPL; SREBF1; UQCR11; NDUFB3; AKT1; SDHA; INSR; NR1H3
Cocaine addiction
GRIN2A; GRM2; TH; SLC18A2; CREB3L4; GRM3; GNAI2; GRIN2B; CREB3L2; DRD1
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1G2; MAPK12; ATP6V0A2; RAC1; ATP6V1A; ATP6V1B2; ADAM17; MAP2K4; CXCR1; ATP6V1C2
Shigellosis
PFN3; MAPK13; UBE2D2; MAPK3; ACTG1; ITGA5; FBXW11; VCL; ELMO2; CDC42
Salmonella infection
KLC2; ROCK2A; PKN1; RAC1A; PFN2L; IFNGR1; IL8L1; MAPK10; CCL4L1; CD14
Pertussis
C1R; ITGA5; C5; TNF; IL12B; IRAK1; CALM4; LY96; MAPK9; RELA
Legionellosis
SEC22B; CLK1; MYD88; RELA; HSPA8; TLR4; EEF1A1; CR1; CASP7; IL12B
Leishmaniasis
HLA-DRB5; HLA-DQB1; NFKBIB; HLA-DPB1; PTPN6; TGFB1; H2-AB1; FCGR3A; NCF2; MAPK3
Chagas disease (American trypanosomiasis)
GNAI1; GNAS; PIK3CA; RELA; MAPK10; IFNGR2; IKBKG; MAP2K4; FAS; IRAK4
Toxoplasmosis
HLA-DRB5; PIK3CG; Toxoplasma Gondii Microneme Protein MIC3; LAMB4; IRGM1; HLA-DPB1; IL12A; TYK2; GNAI2; HSPA6
Amoebiasis
ITGB2; PIK3R5; ACTN3; RAB7B; C8A; PLCB1; ARG1; GM-CSF; LAMA2; C9
Tuberculosis
BID; LAMP1; FCGR3B; CALM1; IFNA4; KSR1; MYD88; IFNA6; SYK; TNF
Hepatitis C
MAPK9; LDLR; CLDN14; IL-8; TNF; RXRA; IFNA13; PPP2R2A; IFN-a; IRF7
Hepatitis B
TGFB3; PRKCG; PIK3CA; BIRC5; PIK3R3; SMAD3; IFNA7; IFIH1; PIK3R2; NFATC1
Measles
BBC3; CCND1; IRF7; STAT1; PIK3CD; PIK3R3; TNFRSF10A; MYD88; IFIH1; CD46
Influenza A
TNF; OAS1A; NFKB1; IL18; GSK3B; TMPRSS2; FAS; AKT1; MAP2K2; TNFRSF1A
HTLV-I infection
IL2RA; Fzd4; CRTC3; HLA-A; HLA-G; MAP3K14; TGFBR2; XBP1; CANX; ANAPC5
Herpes simplex infection
GLTSCR2; IL12B; CDC34; UBE2R2; HCFC2; CASP8; NXF1; PPP1CC; Ifna11; SRSF6
Epstein-Barr virus infection
CSNK2B; GTF2E2; HDAC4; POLR3D; CD40; POLR2B; POLR2H; POLR2D; POLR2G; PIK3R1
Pathways in cancer
LAMA3; EGLN2; FGFR1; RALGDS; CCNE1; LPAR3; MMP1A; GNB4; TRAF6; PIK3CD
Transcriptional misregulation in cancer
TSPAN7; IL3; Aff1; HIST1H3G; PTCRA; SPI1; CDK14; LYL1; ETV5; MET
Viral carcinogenesis
HIST1H4J; HIST1H4D; NFKBIA; HPN; PIK3R3; HLA-B; RHOA; HIST2H2BB; PSMC1; HIST1H4C
MicroRNAs in cancer
MMP9; EFNA3; DNMT3A; Pdgfa&Pdgfb; ITGB3; CCNE1; CDC25B; ERBB3; ABL1; MTOR
Pancreatic cancer
RAD51; MAPK9; TGFBR1; PIK3CD; ERBB2; MAP2K1; RAF1; PIK3R5; AKT2; BCL2L1
Prostate cancer
RAF1; PIK3R5; NDRG1; PIK3CA; HSP90B1; NKX3; TGFA; HSP90AA1; PTEN; INSRR
Chronic myeloid leukemia
TGFBR2; BCL2L1; PIK3R1; GRB2; PIK3R3; BRAF; NFKB1; TP53; CTBP2; AKT2
Acute myeloid leukemia
PIM1; MAP2K2; RELA; CCNA1; MAP2K1; RARA; CCND1; PIM2; RUNX1; PIK3R2
Small cell lung cancer
PIK3CG; TP53; LAMC1; ITGA2; LAMB1; PIK3CA; LAMA2; XIAP; PTEN; TRAF5
Inflammatory bowel disease (IBD)
Il2; IL18RAP; IL23R; IL18; IL1B; STAT4; IL4; HLA-DOB; IL12RB2; NFKB1

Protein Function

NFKB1 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKB1 itself. We selected most functions NFKB1 had, and list some proteins which have the same functions with NFKB1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein HNRNPC; RXRB; REL; H2AFZ; MEOX2; H3F3B; SIX3; JUN; BACH1; TFAP2C
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein LMO2; ZFP551; MYOD1; NHLH2; AASS; BARHL1B; ETV6; NR1D1; XBP1; FOXF1
Function actinin binding
Related Protein NFKB1; CSRP3; RELA; TTN; PROM1; MICALL2; PDLIM5; PKD2
Function chromatin binding
Related Protein MEIOB; CALCOCO1; UBTFL; ING5; MKRN1; SREBF1; OVOL2; CENPB; ZFP932; RNF2
Function heat shock protein binding
Related Protein FKBP4; HSPA8; PPID; PARK2; GM5506; NFKB1; LMAN2; DNAJA2; BAK1; EEF1D
Function identical protein binding
Related Protein ACTG1; SHANK1; SERPINA1E; VPS4B; DNMT3A; DDX58; PHYKPL; SMG9; BNIP3; ATG101
Function protein binding
Related Protein GPR158; PPIL2; SIKE1; RAG1; KCNE1; WDR74; ABCG8; KPNA3; FUBP3; CAPN1
Function protein heterodimerization activity
Related Protein ATF2; HIST1H2BO; DLG4B; HER1; SLC51B; LIFR; UBA2; NEUROD1; SIM2; BAXA
Function protein homodimerization activity
Related Protein TREX2; TIRAP; PRTFDC1; SDCBP2; ADRB3; CD4; CISD2; BIRC5; ODZ4; BAXA
Function regulatory region DNA binding
Related Protein IRF4A; HMGA2; IRF8; IRF1A; IRF1B; IRF6; IRF2A; NFKB1; IRF5; IRF3
Function transcription factor activity, sequence-specific DNA binding
Related Protein VED; ZNF207; FEV; CNOT8; TBX4; RARAA; MAP3K7; FOXI3B; KAT7; ZFP583
Function transcription factor binding
Related Protein SP100; RNF19A; ATF7; PIK3R1; SP1; SORBS3; Ar; HYAL1; RB1; PPP1R13BB
Function transcription regulatory region DNA binding
Related Protein SALL4; SOX17; ZNF335; KLF17; ARID5B; SOX2; FOXA2; RFX6; TFAP4; ATF6B
Function transcription regulatory region sequence-specific DNA binding
Related Protein ARNTL; GATA1; SOX11; TBX18; SUV39H1; PSPC1; SIN3A; NONO; NKX3; SOX4
Function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein POU4F1; FUBP1; NFKB1; NFATC1; ARID3B; HMGA1; PBX3; MIXL1; SIX3; PROP1
Function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein NR2F6; POU5F1; ZEB1; HES6; MSX1; ZC3H8; HMX1; JARID2; MSX2; VAX1

Interacting Protein

NFKB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKB1.
MAP3K8; RELA

NFKB1 Related Articles

Chen, Y; Lu, RQ; et al. The NFKB1 polymorphism (rs4648068) is associated with the cell proliferation and motility in gastric cancer. BMC GASTROENTEROLOGY 15:-(2015).
Jacque, E; Schweighoffer, E; et al. IKK-induced NF-kappa B1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. JOURNAL OF EXPERIMENTAL MEDICINE 211:2085-2101(2014).