nudt1
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  • Official Full Name
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1
  • Background
  • Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
  • Synonyms
  • NUDT1; nudix (nucleoside diphosphate linked moiety X)-type motif 1; MTH1; 7,8-dihydro-8-oxoguanine triphosphatase; 7; 8 dihydro 8 oxoguanine triphosphatase; 8 oxo 7; 8 dihydrodeoxyguanosine triphosphatase; 8 dihydroguanosine triphosphatase; 8 oxo dGTPase
Cat.#:NUDT1-2411HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human NUDT1 Protein (19-197 aa), His-tagged
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Cat.#:NUDT1-2809HTag:His
Source (Host):BaculovirusSpecies:Human
Product nameRecombinant Human NUDT1 Protein (19-197 aa), His-tagged
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Cat.#:NUDT1-1398HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NUDT1, GST-tagged
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Cat.#:NUDT1-775HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NUDT1 Protein, His-tagged
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Cat.#:NUDT1-798HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NUDT1, His-tagged
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Cat.#:NUDT1-10961MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NUDT1 Protein
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Cat.#:NUDT1-4114RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NUDT1 Protein
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Cat.#:NUDT1-3123RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NUDT1 Protein, His-tagged
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Cat.#:NUDT1-1311CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NUDT1
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Cat.#:NUDT1-12590ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NUDT1
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Cat.#:NUDT1-3655HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human NUDT1 293 Cell Lysate
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Cat.#:NUDT1-3656HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human NUDT1 293 Cell Lysate
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Involved Pathway

NUDT1 involved in several pathways and played different roles in them. We selected most pathways NUDT1 participated on our site, such as Metabolism, Metabolism of nucleotides, Phosphate bond hydrolysis by NUDT proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUDT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism
CYP2B6; NUDT4B; PAOX; CERS5; NEU4; ZDHHC21; KHK; KCNB1; MMADHC; KCNS3
Metabolism of nucleotides
DUT; DPYDA.1; UPP2; NUDT18; DCK; DPYS; PNP5B; GLRX; TYMP; ADK
Phosphate bond hydrolysis by NUDT proteins
NUDT15; NUDT18; NUDT16; NUDT1; NUDT5
oxidized GTP and dGTP detoxification
NUDT1

Protein Function

NUDT1 has several biochemical functions, for example, 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity, 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity, ATP diphosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NUDT1 itself. We selected most functions NUDT1 had, and list some proteins which have the same functions with NUDT1. You can find most of the proteins on our site.
Function
Related Protein
Function 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
Related Protein NUDT1; NUDT15
Function 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
Related Protein NUDT15; NUDT1; DOM3Z; NUDT19
Function ATP diphosphatase activity
Related Protein NUDT1
Function GTP diphosphatase activity
Related Protein NUDT1
Function GTPase activity
Related Protein RRAGCA; RAB11B; IRGE4; EEF2B; RAB41; RAB3AA; RAB11BA; RAB5AB; GBP2; GNAV1
Function NOT m7G(5)pppN diphosphatase activity
Related Protein NUDT5; NUDT4; NUDT7; NUDT1; NUDT16L1
Function metal ion binding
Related Protein MGAT4A; MCEE; ZNF43; ZMYND17; ZNF695; HSCB; B3GNT1; CYP27C1; SNAI1A; ATMIN
Function protein binding
Related Protein MDM4; STOML1; CTNNBL1; PARL; LRP1; PIK3CD; SMARCB1; LASP1; TTC25; MPG
Function snoRNA binding
Related Protein NUDT16L1; TBL3; IMP3; DDX21; UTP15; NUDT7; NUDT4; PWP2H; NUDT5; HEATR1

Interacting Protein

NUDT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUDT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUDT1.
HEL-S-5; NTHL1; RNMTL1; s-crizotinib; sch51344; GABARAP; GABARAPL2; MAP1LC3B; GABARAPL1

NUDT1 Related Articles

Albayrak, O; Putter, C; et al. Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 162B:295-305(2013).
Wilson, GRS; Morton, JD; et al. The locus for an inherited cataract in sheep maps to ovine chromosome 6. MOLECULAR VISION 18:1384-1394(2012).