pde1b
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  • Official Full Name
  • phosphodiesterase 1B, calmodulin-dependent
  • Background
  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Synonyms
  • PDE1B; phosphodiesterase 1B, calmodulin-dependent; PDES1B; calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B; cam-PDE 1B; 63 kDa Cam-PDE; calmodulin-stimulated phosphodiesterase PDE1B1; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B; PDE1B1
Cat.#:PDE1B-745HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDE1B Protein, MYC/DDK-tagged
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Cat.#:PDE1B-1164HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDE1B, His & GST tagged
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Cat.#:PDE1B-1599HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDE1B, GST-tagged
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Cat.#:PDE1B-29995THTag:
Source (Host):Species:Human
Product nameRecombinant Human PDE1B
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Cat.#:PDE1B-442HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDE1B, GST-tagged
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Cat.#:PDE1B-12548MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDE1B Protein
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Cat.#:PDE1B-4326RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDE1B Protein
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Cat.#:PDE1B-3346RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PDE1B Protein, His-tagged
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Cat.#:PDE1B-627HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDE1B cell lysate
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Cat.#:Kit-1825Tag:
Source (Host):Species:
Product namePDE1B Assay Kit
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Cat.#:Kit-1827Tag:
Source (Host):Species:
Product namePDE1B TR-FRET Assay Kit
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Cat.#:Kit-1826Tag:
Source (Host):Species:
Product namePDE1B Cell-Based Reporter Assay Kit
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Involved Pathway

PDE1B involved in several pathways and played different roles in them. We selected most pathways PDE1B participated on our site, such as Purine metabolism, Calcium signaling pathway, Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
PDE10A; PDE6C; ITPA; AK1; ADA; GUCY2E; GUCY2C; AMPD3; GMPS; PDE1C
Calcium signaling pathway
PPP3R2; NOS1; TRHR; GNA11A; MYLK; CAMK2D1; PRKACBB; TACR3; PRKACA; PLCB4
Olfactory transduction
OLFR24; CALM3; OLFR958; OLFR18; SLC8A2; CALML3; CAMK2D; ANO2; OR10J1; OLFR49
Renin secretion
CALM4; PPP3CA; PDE1C; AGTR1A; PPP3CC; CLCA3; PLCB4; GNAS; PPP3R2; REN2
Morphine addiction
GABRR1; PRKACG; PDE11A; GABRR3; GNAI1; GABBR2; LOC100328615; GRK5; PDE4C; GNB4

Protein Function

PDE1B has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, calcium- and calmodulin-regulated 3,5-cyclic-GMP phosphodiesterase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE1B itself. We selected most functions PDE1B had, and list some proteins which have the same functions with PDE1B. You can find most of the proteins on our site.
Function
Related Protein
Function 3,5-cyclic-AMP phosphodiesterase activity
Related Protein PDE4D; PDE7A; PDE4A; PDE4B; PDE1B; PDE4C; USB1; PDE8B; PDE8A; TDP2B
Function calcium- and calmodulin-regulated 3,5-cyclic-GMP phosphodiesterase activity
Related Protein PDE1B
Function calmodulin binding
Related Protein ATP2B4; KCNQ1; PPP3CA; MYO1G; MYO1D; AEBP1; RIT2; MYO5C; MYH3; UBR4
Function calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
Related Protein TDP2B; USB1; PDE1B; PDE1A; PDE1C
Function metal ion binding
Related Protein MUSK; LIMCH1B; ASAP3; HIVEP2; NEK1; AGFG1B; MTL5; ATP2A1L; ZHX1; TRIM43C
Function protein binding
Related Protein FOXM1; PGF; PWWP2B; HSP90B1; TAF1C; KNG1; LONP1; TERF2; VPS28; LAMA4

Interacting Protein

PDE1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE1B.
POT1; UBE3A