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Official Full Name phosphodiesterase 1B, calmodulin-dependent
Background The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms PDE1B; phosphodiesterase 1B, calmodulin-dependent; PDES1B; calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B; cam-PDE 1B; 63 kDa Cam-PDE; calmodulin-stimulated phosphodiesterase PDE1B1; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B; PDE1B1
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His/GST
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PDE1B-04H Recombinant Human PDE1B Protein, His/GST-tagged Insect Cell His/GST
    Human PDE1B-2292H Recombinant Human PDE1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Pde1b-4743M Recombinant Mouse Pde1b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PDE1B-1164H Recombinant Human PDE1B, His & GST tagged Insect Cell His/GST
    Human PDE1B-1599H Recombinant Human PDE1B, GST-tagged E.coli GST
    Human PDE1B-29995TH Recombinant Human PDE1B N/A
    Human PDE1B-442H Recombinant Human PDE1B, GST-tagged Sf9 Insect Cell GST
    Human PDE1B-627HCL Recombinant Human PDE1B cell lysate Insect Cell N/A
    Human PDE1B-745H Recombinant Human PDE1B Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse PDE1B-12548M Recombinant Mouse PDE1B Protein Mammalian Cell His
    Rat PDE1B-4326R Recombinant Rat PDE1B Protein Mammalian Cell His
    Rhesus Macaque PDE1B-3346R Recombinant Rhesus monkey PDE1B Protein, His-tagged Mammalian Cell His
    Kit-1825 PDE1B Assay Kit N/A
    Kit-1826 PDE1B Cell-Based Reporter Assay Kit N/A
    Kit-1827 PDE1B TR-FRET Assay Kit N/A

    PDE1B involved in several pathways and played different roles in them. We selected most pathways PDE1B participated on our site, such as Purine metabolism, Calcium signaling pathway, Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism NME2B.2; POLR1C; ADA; POLR2A; DGUOK; HDDC3; DCK; POLR3GL; PRUNE; NUDT5
    Calcium signaling pathway CACNA1B; HTR2A; TACR1A; P2RX3A; F2R; CALM1; HTR5A; ATP2A2A; ITPR3; CALM3B
    Olfactory transduction OLFR497; OLFR493; GUCY2E; OLFR5; CAMK2B; OLFR508; PDE1C; PRKACB; OR5B2; OR6K3
    Renin secretion GNAI3; PDE1C; PDE3A; PLCB1; PTGER2; PRKG2; CLCA4; PDE1A; PTGER4; REN2
    Morphine addiction GABBR1; GNG12; GABRA1; GABRR2; GNG7; PDE8A; GNGT2; PDE4A; GABRG2; GNAS

    PDE1B has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, calcium- and calmodulin-regulated 3,5-cyclic-GMP phosphodiesterase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE1B itself. We selected most functions PDE1B had, and list some proteins which have the same functions with PDE1B. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-AMP phosphodiesterase activity PDE7A; TDP2B; PDE4C; PDE8B; PDE4D; PDE4B; PDE4A; USB1; PDE3A; PDE7B
    calcium- and calmodulin-regulated 3,5-cyclic-GMP phosphodiesterase activity PDE1B
    calmodulin binding MYO1G; MARCKSL1B; MYO9B; EPB41B; OBSCN; PNCK; ORAI1; KCNN1A; MARCKSL1; RYR1
    calmodulin-dependent cyclic-nucleotide phosphodiesterase activity TDP2B; USB1; PDE1A; PDE1B; PDE1C
    metal ion binding FKBP8; PRKCI; POLR2B; ALOX8; ZSCAN2; ZFP12; Adamts19; FTR14; ASGR1; ZC3H3
    protein binding PCTP; FZD5; RWDD2B; ZFP110; ASTE1; RTN4; GOSR2; WBP11; SH3GL1; PHB

    PDE1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE1B.

    POT1; UBE3A

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