pten
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  • Official Full Name
  • phosphatase and tensin homolog
  • Background
  • This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PTEN; phosphatase and tensin homolog; BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatase and tensin-like protein; mutated in multiple advanced cancers 1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;
Cat.#:PTEN-342HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTEN Protein, His-tagged
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Cat.#:PTEN-1619HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Phosphatase And Tensin Homolog, GST-tagged
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Cat.#:PTEN-2042HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTEN, GST-tagged
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Cat.#:PTEN-523HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PTEN protein, His-tagged
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Cat.#:PTEN-663HTag:His
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human PTEN Protein, His-tagged
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Cat.#:PTEN-13631MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PTEN Protein
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Cat.#:PTEN-3686RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PTEN Protein, His-tagged
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Cat.#:PTEN-1094HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphatase And Tensin Homolog
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Cat.#:PTEN-482HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Phosphatase And Tensin Homolog
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Cat.#:PTEN-2721HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PTEN 293 Cell Lysate
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Involved Pathway

PTEN involved in several pathways and played different roles in them. We selected most pathways PTEN participated on our site, such as Inositol phosphate metabolism, FoxO signaling pathway, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTEN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PIP5K1B; MTMR2; PLCZ1; INPP5A; ITPK1; PLCH2; NUDT4A; ALDH6A1; PTENB; PIP5KL1
FoxO signaling pathway
G6PCA.1; ATM; TGFB2; KLF2B; GABARAPA; MAPK9; CDKN2B; KLF2; BRAF; GADD45AA
Phosphatidylinositol signaling system
PPIP5K1; ITPKC; IMPA1; PIP4K2C; PLCD3A; PIK3C2B; PI4KB; INPPL1A; PIP4K2AA; PIP5K1C
Sphingolipid signaling pathway
RHOA; PIK3R2; PLD2; TRP53; TNFRSF1A; GNAI3; GNAI2; PPP2R2C; PPP2R3C; S1PR4
p signaling pathway
SHISA5; CCND1; PTENA; BAXA; MDM2; RRM2B; CASP9; CCNE2; THBS1; GADD45AB
mTOR signaling pathway
MAPK1; VEGFA; RPS6KA6; EIF4BB; RRAGCB; CAB39; ULK1; RRAGD; INSB; RPTOR
PIK-Akt signaling pathway
PPP2R1B; LAMB1; PPP2R5C; GH1; RPS6; TNN; PCK2; EIF4E1B; ITGA8; IL4
Focal adhesion
MYL12.2; LAMC2; MAPK8B; RAPGEF1; PPP1R12C; PRKCBB; VASP; PIK3R3B; MYLPFB; PPP1CBL
Tight junction
SPTAN1; PRKCH; AKT2L; F11R; PARD6A; CLDN10; EPB41L3B; RHOAA; SHROOM2; ACTN3A
Insulin resistance
NFKBIAA; RPS6KAL; MAPK8A; MAPK8; G6PC3; PCK2; CRTC2; TNF; SLC27A4; IRS1
Hepatitis B
CCNE2; AKT2; BAX; IFNA21; RELA; STAT3; TICAM2; TP53; SRC; BAD
Pathways in cancer
TRAF4; FZD2; LPAR2; HSP90AB1; CCNE2; BIRC7; TGFB1; NFKBIA; WNT7A; RELA
MicroRNAs in cancer
RDX; MMP9; FGFR3; PIK3R2; ABCC1; Pdgfa&Pdgfb; NOTCH3; HOXD10; FOXP1; ABCB1A
Endometrial cancer
CCND1; TRP53; PIK3R3; PDPK1; GSK3B; BAD; MAP2K2; CTNNA2; MAP2K1; ILK
Glioma
TRP53; CAMK2D; CCND1; CALM2; PIK3CD; RAF1; PTEN; CALM4; ARAF; PRKCA
Prostate cancer
INS2; TCF7; ACTL6B; GSK3B; ARID1A; FOXA1; SPINK1; MTOR; TRP53; NRAS
Melanoma
HGF; FGF16; PDGFB; NRAS; FGF12; PDGFA; IGF1R; FGF8; PIK3R2; TP53
Small cell lung cancer
ITGAV; PTGS2; PIK3CD; CKS2; TRAF6; XIAP; PTK2; IKBKG; TRP53; LAMA4
Central carbon metabolism in cancer
G6PD; SLC2A2; MTOR; SLC1A5; RAF1; IDH1; PDHA1; GLS2; MAP2K1; AKT2

Protein Function

PTEN has several biochemical functions, for example, PDZ domain binding, anaphase-promoting complex binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTEN itself. We selected most functions PTEN had, and list some proteins which have the same functions with PTEN. You can find most of the proteins on our site.
Function
Related Protein
Function PDZ domain binding
Related Protein GRIA1; SLC9A3R2; ATP2B1A; USHBP1; PROSAPIP1; F11R; DLG3; MAP2K2; GIPC1; GRIK5
Function anaphase-promoting complex binding
Related Protein PTEN; CLSPN; PLK1
Function enzyme binding
Related Protein CYP2C8; Ar; SLPI; CBS; HIST1H2AI; UGT1A7; RPS3; KDM4C; CALU; HNRNPUL1
Function identical protein binding
Related Protein PTPRM; C14orf166; MBIP; SP100; MTPAP; SRI; TARDBP; RALYL; VIL1; DRD2
Function inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
Related Protein PTEN
Function lipid binding
Related Protein PCYT1A; STARD6; SEC14L4; TRIP10A; HSP12; UNC119; FABP7A; BPIFB3; VCP; EPN1
Function magnesium ion binding
Related Protein NT5C1B; GEM; CIB3; EPHX2; ENO1A; ABL1; ITPK1A; ERN2; RPS6KA3B; PINK1
Function phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
Related Protein PTENB; PTENA; PTEN
Function phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
Related Protein PTEN; PTENA; PTENB
Function phosphatidylinositol-3-phosphatase activity
Related Protein FIG4; PTEN; MTM1; MTMR1B; MTMR2; SACM1L; MTMR1; MTMR8; MTMR3; MTMR14
Function phosphoprotein phosphatase activity
Related Protein PPM1AA; PTPRU; CDC14A; PTPN2B; PTPRUB; PPM1LA; CTDSPL2A; PTEN; PPTC7A; CTDNEP1A
Function platelet-derived growth factor receptor binding
Related Protein PDGFAA; PDGFRA; VEGFA; ITGB3; PDGFD; Pdgfa&Pdgfb; LYN; TYMP; PDGFA; PTEN
Function protein binding
Related Protein LIG4; CCDC53; GTF3C3; MED30; PPP3CB; C1orf109; ATPAF1; DLL4; CEACAM21; PAX8
Function protein kinase binding
Related Protein TELO2; CCNT2B; FGF19; STX1B; CNPPD1; PKD1; MLKL; TPRKB; THY1; ADIPOR1
Function protein serine/threonine phosphatase activity
Related Protein PPM1AA; PPP5C; PPM1H; UBLCP1; PPM1BB; LCK; CTDNEP1; PDP1; PPEF1; PPEF2
Function protein tyrosine phosphatase activity
Related Protein PTPN4B; PTEN; DUSP5; TPTE; CDC25D; DUSP9; PTPRC; PTP4A2A; SSH2B; CDC14AA
Function protein tyrosine/serine/threonine phosphatase activity
Related Protein PXYLP1; SACM1L; DUPD1; DUSP3B; CDC14B; DUSP22A; CDKN3; PTP4A2A; DUSP9; TPTE

Interacting Protein

PTEN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTEN here. Most of them are supplied by our site. Hope this information will be useful for your research of PTEN.
SLC9A3R1; PDGFRB; FRK; SLC9A3R2

PTEN Related Articles

Ritprajak, P; Azuma, M; et al. Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma. ORAL ONCOLOGY 51:221-228(2015).
Collaud, S; Tischler, V; et al. Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN. BMC CANCER 15:-(2015).