pthlh
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  • Official Full Name
  • parathyroid hormone-like hormone
  • Background
  • The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.
  • Synonyms
  • PTHLH; HHM; PLP; BDE2; PTHR; PTHRP; MGC14611; parathyroid hormone-like hormone; Parathyroid hormone-related protein
Cat.#:PTHLH-111HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Parathyroid Hormone-like Hormone
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Cat.#:PTHLH-112HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTHLH, His-tagged
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Cat.#:PTHLH-322HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PTHLH
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Cat.#:PTHLH-664HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTHLH Protein
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Cat.#:PTHLH-665HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTHLH Protein, His-tagged
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Cat.#:PTHLH-666HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTHLH Protein, His-tagged
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Cat.#:Pthlh-7767MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pthlh protein, His-tagged
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Cat.#:PTHLH-4821RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTHLH Protein
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Cat.#:Pthlh-7768RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pthlh protein, His & S-tagged
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Cat.#:PTHLH-3695RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PTHLH Protein, His-tagged
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Cat.#:PTHLH-7765DTag:His/S
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog PTHLH protein, His & S-tagged
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Cat.#:PTHLH-4076CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTHLH
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Cat.#:PTHLH-7766CTag:His/S
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken PTHLH protein, His & S-tagged
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Cat.#:PTHLH-7764CTag:His/S
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle PTHLH protein, His & S-tagged
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Cat.#:PTHLH-2701HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PTHLH 293 Cell Lysate
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Cat.#:PTHLH-2702HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PTHLH 293 Cell Lysate
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Cat.#:PTHLH-2703HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PTHLH 293 Cell Lysate
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Involved Pathway

PTHLH involved in several pathways and played different roles in them. We selected most pathways PTHLH participated on our site, such as Class B/2 (Secretin family receptors), Endochondral Ossification, G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTHLH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Class B/2 (Secretin family receptors)
PTHRP2; CD97; ADCYAP1B; PTHLHA; CRHB; EMR3; GCGA; ADM2; GHRH; FZD10
Endochondral Ossification
SERPINH1; MMP13; RUNX3; NKX3.2; PTH; PTHLH; FRZB; DDR2; ADAMTS5; ADAMTS4
G alpha (s) signalling events
CRHR1; TAAR1; CRHB; CRHR2; RLN3A; GHRH; RAMP1; ADORA2A; CGA; CALCB
GPCR downstream signaling
INSL5; OR10A5; OPN4A; GNA13; VIP2; PENKB; RGS7; RGS6; DGKB; CNR1
GPCR ligand binding
OXGR1A.2; S1PR1; NPS; HEBP1; ADRA2B; CD97; PENKB; TAS2R7; GPR31B; CCRL2
Signal Transduction
SDR9C7; ARHGAP20; ARHGAP24; EVC; MDKB; PAG1; TJP2B; NCKIPSD; BBS13; RAB6A
Signaling by GPCR
OXGR1A.2; ARHGEF17; GPR55A; OXGR1A.1; PENKB; OPN5; RGS4; RGS14; NPB; PENKA
Signaling events mediated by the Hedgehog family
PTHLH; LRPAP1

Protein Function

PTHLH has several biochemical functions, for example, hormone activity, peptide hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTHLH itself. We selected most functions PTHLH had, and list some proteins which have the same functions with PTHLH. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein LEPA; PRL7B1; AGT; CALCA; SMTLA; FSD1; URP2; PRL7A2; GCG; EDN1
Function peptide hormone receptor binding
Related Protein NPPC; PTHLHA; RUNDC3A; JAK2; PTPN11; NPPA; LEP; PTHLH; PTH; ADCYAP1

Interacting Protein

PTHLH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTHLH here. Most of them are supplied by our site. Hope this information will be useful for your research of PTHLH.
PLK1

PTHLH Related Articles

Dale, MD; Mortimer, EM; et al. Bone-Remodeling Transcript Levels Are Independent of Perching in End-of-Lay White Leghorn Chickens. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16:2663-2677(2015).
Galloway, TS; Fletcher, T; et al. PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. CHEMOSPHERE 120:555-562(2015).