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PTHLH

  • Official Full Name

    parathyroid hormone-like hormone

  • Overview

    The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.
  • Synonyms

    PTHLH; HHM; PLP; BDE2; PTHR; PTHRP; MGC14611; parathyroid hormone-like hormone; Parathyroid hormone-related protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Dog
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Protein Conjugation
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|S
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTHLH-111H Recombinant Human Parathyroid Hormone-like Hormone E.coli N/A
Human PTHLH-664H Recombinant Human PTHLH protein E.coli N/A 86
Human PTHLH-112H Recombinant Human PTHLH, His-tagged E.coli His
Human PTHLH-665H Recombinant Human PTHLH Protein, His-tagged E.coli His 37-175aa
Human PTHLH-666H Recombinant Human PTHLH Protein, His-tagged E.coli His
Human PTHLH-322H Recombinant Human PTHLH Mammalian Cell His
Human PTHLH-2701HCL Recombinant Human PTHLH 293 Cell Lysate HEK293 N/A
Human PTHLH-2702HCL Recombinant Human PTHLH 293 Cell Lysate HEK293 N/A
Human PTHLH-2703HCL Recombinant Human PTHLH 293 Cell Lysate HEK293 N/A
Human PTHLH-339H Recombinant Human PTHLH protein E.coli N/A 86
Human PTHLH-3943H-B Recombinant Human PTHLH Protein Pre-coupled Magnetic Beads HEK293
Human PTHLH-4047H Recombinant Human PTHLH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTHLH-113H Recombinant Human PTHLH protein, His/S-tagged E.coli His/S 193
Human PTHLH-3943H Recombinant Human PTHLH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PTHLH-6703H Recombinant Human PTHLH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTHLH-6076H Recombinant Human PTHLH Protein (Ala37-Arg175), C-His tagged E.coli C-His Ala37-Arg175
Human PTHLH-301482H Recombinant Human PTHLH protein, GST-tagged E.coli GST Ala37-Arg175
Mouse Pthlh-7767M Recombinant Mouse Pthlh protein, His-tagged E.coli His Ala37~His175
Mouse Pthlh-5226M Recombinant Mouse Pthlh Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Pthlh-7768R Recombinant Rat Pthlh protein, His & S-tagged E.coli His/S Ala37~His177 (Accession # P13085)
Rat PTHLH-4821R Recombinant Rat PTHLH Protein Mammalian Cell His
Rat PTHLH-4480R Recombinant Rat PTHLH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Pthlh-2830R Recombinant Rat Pthlh Protein, His-tagged, KLH Conjugated Protein Conjugation N-His Thr69-Pro84
Rat PTHLH-4480R-B Recombinant Rat PTHLH Protein Pre-coupled Magnetic Beads HEK293
Dog PTHLH-7765D Recombinant Dog PTHLH protein, His & S-tagged E.coli His/S Ala37~His177 (Accession # P52211)
Cattle PTHLH-7764C Recombinant Cattle PTHLH protein, His & S-tagged E.coli His/S Ala37~His177 (Accession # P58073)
Rhesus Macaque PTHLH-3695R Recombinant Rhesus monkey PTHLH Protein, His-tagged Mammalian Cell His
Rhesus Macaque PTHLH-3513R Recombinant Rhesus Macaque PTHLH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PTHLH-3513R-B Recombinant Rhesus Macaque PTHLH Protein Pre-coupled Magnetic Beads HEK293
Chicken PTHLH-7766C Recombinant Chicken PTHLH protein, His & S-tagged E.coli His/S Ala38~Arg176 (Accession # P17251)
Chicken PTHLH-4076C Recombinant Chicken PTHLH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTHLH Related Articles

PTHLH involved in several pathways and played different roles in them. We selected most pathways PTHLH participated on our site, such as Class B/2 (Secretin family receptors), Endochondral Ossification, G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTHLH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class B/2 (Secretin family receptors)GCGB;FZD10;PTHLH;PTHRP2;PTH2;ADM2A;PTHLHA;CRHB;SETD6
Endochondral OssificationCOL10A1;NKX3-2;CST5;NKX3.2;CDKN1C;MGP;SOX5;CTSL2;RUNX2A
G alpha (s) signalling eventsADM2;RLN3;GCGA;RAMP2;GPBAR1;ADCYAP1B;VIP2;CRHR2;ADM2A
GPCR downstream signalingUTS2D;RGS20;PROKR1A;VIP;CALCA;TAS2R13;GPR132;OXER1;CHRM3
GPCR ligand bindingGPR77;CCK;GPR39;EMR3;ADRA2B;OPN1MW;TAAR1;ADM2A;NPSR1
Signal TransductionGMIP;ARHGEF1A;ABR;RYK;FAM13B1;TTC21B;JUPA;RGS20;FAM13A
Signaling by GPCRUTS2;PROKR1;GPR132B;GPR65;TAS2R7;GPR55A;OPN4A;GPR120;RGS11
Signaling events mediated by the Hedgehog familyPTHLH;LRPAP1

PTHLH has several biochemical functions, for example, hormone activity, peptide hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTHLH itself. We selected most functions PTHLH had, and list some proteins which have the same functions with PTHLH. You can find most of the proteins on our site.

Function Related Protein
hormone activityINHBAB;ADCYAP1A;SST1.1;PRL8A8;LEP;PPY;ADM2A;INS-IGF2;EPO
peptide hormone receptor bindingLEP;PTH;FYN;RUNDC3A;NPPA;ADCYAP1;PTPN11;PTHLH;NPPC

PTHLH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTHLH here. Most of them are supplied by our site. Hope this information will be useful for your research of PTHLH.

PLK1

Dale, MD; Mortimer, EM; et al. Bone-Remodeling Transcript Levels Are Independent of Perching in End-of-Lay White Leghorn Chickens. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16:2663-2677(2015).
Galloway, TS; Fletcher, T; et al. PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. CHEMOSPHERE 120:555-562(2015).
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