Recombinant Human Parathyroid Hormone-like Hormone

• Cat.No.: PTHLH-111H
• Product Overview: Recombinant Human PTHrP produced inE.Coliis a 9.8 kDa protein consisting of 86 amino acid residues.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: Human Parathyroid Hormone-like related Protein (PTHrP) -is a member of the Parathyroid hormone family that is expressed in the mammary gland. It is known as a potent inhibitor of chondrocyte maturation. PTHrP is expressed by periarticular perichondrial cells and exerts its biological activity on PP-R expressing cells. During endochondral bone development PTHrP plays a major role in suppressing the onset of hypertrophic differentiation. It is also responsible for most cases of humoral hypercalcemia of malignancy.
• Supplied: The sterile filtered solution is lyophilized from 0.5x PBS, pH 7.1.
• Reconstitution: The lyophilized powder should be reconstituted in sterile DI water to a max concentration of 0.1-1mg/ml. Allow to set at least 30 minutes at 4°C, tighten cap and rotate to reconstitute any material on sides of vial. If desired, you can centrifuge at 1000 rpm for 1 minute to concentrate volume in bottom of vial. This solution can be diluted into water or other buffered solutions or stored at 4°Cfor up to 1 week or at – 20°Cfor future use.
• Note: If this material is not to be used for coating or labeling(or other applications requiring carrier free material), the addition of 0.1% BSA to dilution buffers or dilution in sterile culture media is recommended to enhance stability and minimize absorption to vial.
• Endotoxin: less than 0.1ng per ug.
• Reactivity: not determined
• Purity: >98% by SDS-Page and HPLC analysis.
• Storage: The lyophilized powder is stable at room temperature for a few weeks but it is best stored desiccated at -20°C. Reconstituted material should be stored in working aliquots at -20°C.Please avoid freeze-thaw cycles.
• Publications:
  Measurements of Osteoanabolic agents PTH (1-34) and PTHrP (1-36) in therapeutic studies and clinical diagnostics. (2017)

Gene Information

• Gene Name: PTHLH parathyroid hormone-like hormone [ Homo sapiens ]
• Synonyms: PTHLH; parathyroid hormone-like hormone; HHM; PLP; PTHR; PTHRP; MGC14611; osteostatin; PTH-related protein; parathyroid-like protein; parathyroid hormone-like protein; humoral hypercalcemia of malignancy; parathyroid hormone-related protein; parathyroid hormone-like related protein; PTH-rP; PTHrP; parathyroid hormone-like hormone
• Gene ID: 5744
• mRNA Refseq: NM_002820
• Protein Refseq: NP_002811
• MIM: 168470
• UniProt ID: P12272
• Chromosome Location: 12p12.1-p11.2
• Function: calcium ion binding; hormone activity