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PTPN6

  • Official Full Name

    protein tyrosine phosphatase, non-receptor type 6

  • Overview

    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms

    PTPN6; protein tyrosine phosphatase, non-receptor type 6; HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1; tyrosine-protein phosphatase non-receptor type 6; hematopoietic cell phosphatase; protein-tyrosine phosphatase 1C; protein-tyrosine phosphatase SHP-1; hematopoietic cell protein-tyrosine phosphatase;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Strep
  • SUMO
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTPN6-71H Active Recombinant Human Protein Tyrosine Phosphatase, Non-receptor Type 6 E.coli N/A
Human PTPN6-1520H Active Recombinant Human PTPN6, GST-tagged E.coli GST Full length
Human PTPN6-289H Active Recombinant Human PTPN6 protein, His-tagged E.coli His
Human PTPN6-31401TH Recombinant Human PTPN6 E.coli N/A
Human PTPN6-222H Recombinant Human PTPN6 protein, His-tagged E.coli His Lys243-Ile541
Human PTPN6-1802H Recombinant Human PTPN6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PTPN6-2576H Recombinant Human PTPN6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTPN6-3390H Recombinant Human PTPN6 protein, His-SUMO-tagged E.coli His-SUMO 1-597aa
Human PTPN6-3129H Recombinant Human PTPN6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PTPN6-0697H Recombinant Human PTPN6 Protein (M1-K595), Tag Free E.coli No tag M1-K595
Human PTPN6-2501H Recombinant Human PTPN6 protein, His-tagged E.coli His 506-598 aa
Human PTPN6-6233H Recombinant Human PTPN6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTPN6-1360HFL Recombinant Full Length Human PTPN6 Protein, C-Flag-tagged Mammalian cells Flag
Human PTPN6-0698H Recombinant Human PTPN6 Protein (M1-K595), His/Strep tagged E.coli His/Strep M1-K595
Human PTPN6-1802H-B Recombinant Human PTPN6 Protein Pre-coupled Magnetic Beads HEK293
Human PTPN6-6096H Recombinant Human PTPN6 Protein (Lys243-Ile541), C-His tagged E.coli C-His Lys243-Ile541
Human PTPN6-6098H Recombinant Human PTPN6 Protein (Phe244-Phe515), N-His tagged E.coli N-His Phe244-Phe515
Mouse Ptpn6-8685M Recombinant Mouse Ptpn6, His-GST tagged Insect Cell His
Mouse PTPN6-001MCL Recombinant Mouse PTPN6 cell lysate Insect Cell N/A
Mouse PTPN6-0257M Recombinant Mouse PTPN6 protein, His&GST-tagged Insect Cells His/GST Ala207-Lys597
Mouse Ptpn6-1102M Recombinant Mouse Ptpn6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat PTPN6-4835R Recombinant Rat PTPN6 Protein Mammalian Cell His
Rat PTPN6-4494R Recombinant Rat PTPN6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTPN6-4494R-B Recombinant Rat PTPN6 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PTPN6-10326Z Recombinant Zebrafish PTPN6 Mammalian Cell His
Chicken PTPN6-3131C Recombinant Chicken PTPN6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTPN6 Related Articles

PTPN6 involved in several pathways and played different roles in them. We selected most pathways PTPN6 participated on our site, such as Adherens junction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adherens junctionRAC2;FYNB;ACTG1;CDC42L;ACP1;ACTN1;FGFR1;RAC1B;VCLA
Jak-STAT signaling pathwayIL11RA;IFNAR2;IL5;CCND2;CRFB2;CSF3R;IL2RB;CCND1;LIFR
Natural killer cell mediated cytotoxicityNCR2;TNFRSF10A;KIR2DS5;KLRC2;HLA-G;NCR3;ITGB2;GM-CSF;Raet1c
T cell receptor signaling pathwayCD3E;TNF;NFATC1;NFATC3;MAPK3;PDPK1;PIK3CB;PAK3;GSK3B
B cell receptor signaling pathwayAKT1;DOK1;PIK3CD;NEDD9;PPP3R1;NFKBIB;PIK3CA;LILRB3;ARPC4
LeishmaniasisNFKBIB;FCGR1A;NOS2;HLA-DPB1;PRKCB;MYD88;MAP3K7;NCF2;HLA-DQA2
Proteoglycans in cancerBRAF;FN1;CD63;MAPK11;WNT7A;ARAF;PIK3CB;CD44;MET

PTPN6 has several biochemical functions, for example, protein binding, protein kinase binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN6 itself. We selected most functions PTPN6 had, and list some proteins which have the same functions with PTPN6. You can find most of the proteins on our site.

Function Related Protein
protein bindingCIAPIN1;SMAD7;LAPTM5;ZNF544;NOP2;NPLOC4;CRTC1;CDC73;OTX2
protein kinase bindingRAD9;SLC12A7;CDK5RAP2;CDKN2C;RACGAP1;SKAP1;CDK5;MAPK8IP2;RPS19
protein tyrosine phosphatase activityDUSP3;SSH2B;PTPN6;PTPN22;CDC14B;DUSP13A;PTPN23;PTPRA;MTMR3
transmembrane receptor protein tyrosine phosphatase activityPTPRF;PTPRA;PTPRD;EVLA;PTPRC;PTPRN2;PTPRS;PTPRR;PTPRM

PTPN6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN6.

KIR2DL3; EPOR

Li, YF; Xu, SL; et al. Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool. NATURE COMMUNICATIONS 5:-(2014).
Youssef, G; Gillett, C; et al. Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: A potential novel prognostic marker for breast cancer. MODERN PATHOLOGY 27:361-374(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does PTPN6 function as a negative regulator in immune cells? 09/13/2022

PTPN6 acts as a phosphatase, removing phosphate groups from specific tyrosine residues in signaling molecules, thereby downregulating immune cell activation.

Can PTPN6 be a potential target for immunotherapy? 08/04/2020

Yes, PTPN6 modulation is being explored as a potential target for immunotherapies aimed at enhancing or suppressing immune responses based on the clinical context.

How does PTPN6 impact T cell signaling, and why is this important in clinical contexts? 09/09/2018

PTPN6 negatively regulates T cell receptor signaling, and its modulation can have implications in controlling excessive immune responses seen in autoimmune diseases.

Are there specific diseases where the clinical application of PTPN6 is being investigated? 10/02/2017

Yes, PTPN6 is being studied in diseases like rheumatoid arthritis, lupus, and certain types of leukemia and lymphoma.

In what ways can PTPN6 be targeted for therapeutic interventions? 08/24/2016

Researchers are exploring small molecule inhibitors and gene therapies to modulate PTPN6 activity, with potential applications in autoimmune disorders and cancer treatment.

Customer Reviews (3)

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Reviews
07/01/2020

    Structural biology researchers can leverage its properties to better understand the three-dimensional architecture and conformational changes of proteins, gaining valuable insights into their function and interactions.

    04/03/2018

      PTPN6 protein is highly recommended for various research applications, including ELISA and protein electron microscopy structure analysis.

      12/07/2017

        PTPN6 protein might have biomarker properties, meaning its levels or activity could be indicative of disease progression or treatment response.

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