PTPN6
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Official Full Name
protein tyrosine phosphatase, non-receptor type 6
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Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] -
Synonyms
PTPN6; protein tyrosine phosphatase, non-receptor type 6; HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1; tyrosine-protein phosphatase non-receptor type 6; hematopoietic cell phosphatase; protein-tyrosine phosphatase 1C; protein-tyrosine phosphatase SHP-1; hematopoietic cell protein-tyrosine phosphatase;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Strep
- SUMO
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- PTPN6 Related Articles
PTPN6 involved in several pathways and played different roles in them. We selected most pathways PTPN6 participated on our site, such as Adherens junction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adherens junction | RAC2;FYNB;ACTG1;CDC42L;ACP1;ACTN1;FGFR1;RAC1B;VCLA |
Jak-STAT signaling pathway | IL11RA;IFNAR2;IL5;CCND2;CRFB2;CSF3R;IL2RB;CCND1;LIFR |
Natural killer cell mediated cytotoxicity | NCR2;TNFRSF10A;KIR2DS5;KLRC2;HLA-G;NCR3;ITGB2;GM-CSF;Raet1c |
T cell receptor signaling pathway | CD3E;TNF;NFATC1;NFATC3;MAPK3;PDPK1;PIK3CB;PAK3;GSK3B |
B cell receptor signaling pathway | AKT1;DOK1;PIK3CD;NEDD9;PPP3R1;NFKBIB;PIK3CA;LILRB3;ARPC4 |
Leishmaniasis | NFKBIB;FCGR1A;NOS2;HLA-DPB1;PRKCB;MYD88;MAP3K7;NCF2;HLA-DQA2 |
Proteoglycans in cancer | BRAF;FN1;CD63;MAPK11;WNT7A;ARAF;PIK3CB;CD44;MET |
PTPN6 has several biochemical functions, for example, protein binding, protein kinase binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN6 itself. We selected most functions PTPN6 had, and list some proteins which have the same functions with PTPN6. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | CIAPIN1;SMAD7;LAPTM5;ZNF544;NOP2;NPLOC4;CRTC1;CDC73;OTX2 |
protein kinase binding | RAD9;SLC12A7;CDK5RAP2;CDKN2C;RACGAP1;SKAP1;CDK5;MAPK8IP2;RPS19 |
protein tyrosine phosphatase activity | DUSP3;SSH2B;PTPN6;PTPN22;CDC14B;DUSP13A;PTPN23;PTPRA;MTMR3 |
transmembrane receptor protein tyrosine phosphatase activity | PTPRF;PTPRA;PTPRD;EVLA;PTPRC;PTPRN2;PTPRS;PTPRR;PTPRM |
PTPN6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN6.
KIR2DL3; EPOR
- Q&As
- Reviews
Q&As (5)
Ask a questionPTPN6 acts as a phosphatase, removing phosphate groups from specific tyrosine residues in signaling molecules, thereby downregulating immune cell activation.
Yes, PTPN6 modulation is being explored as a potential target for immunotherapies aimed at enhancing or suppressing immune responses based on the clinical context.
PTPN6 negatively regulates T cell receptor signaling, and its modulation can have implications in controlling excessive immune responses seen in autoimmune diseases.
Yes, PTPN6 is being studied in diseases like rheumatoid arthritis, lupus, and certain types of leukemia and lymphoma.
Researchers are exploring small molecule inhibitors and gene therapies to modulate PTPN6 activity, with potential applications in autoimmune disorders and cancer treatment.
Customer Reviews (3)
Write a reviewStructural biology researchers can leverage its properties to better understand the three-dimensional architecture and conformational changes of proteins, gaining valuable insights into their function and interactions.
PTPN6 protein is highly recommended for various research applications, including ELISA and protein electron microscopy structure analysis.
PTPN6 protein might have biomarker properties, meaning its levels or activity could be indicative of disease progression or treatment response.
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