rangap1
Share
  • Official Full Name
  • Ran GTPase activating protein 1
  • Background
  • RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
  • Synonyms
  • RANGAP1; Ran GTPase activating protein 1; SD, segregation distorter homolog (Drosophila); ran GTPase-activating protein 1; Fug1; KIAA1835; segregation distortion; segregation distorter homolog; SD; MGC20266
Cat.#:RANGAP1-30474THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RANGAP1, His-tagged
+Inquiry
Cat.#:RANGAP1-38HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human RANGAP1 protein, GST-tagged
+Inquiry
Cat.#:RANGAP1-42HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RANGAP1 protein, MYC/DDK-tagged
+Inquiry
Cat.#:RANGAP1-682HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ran GTPase Activating Protein 1, GST-tagged
+Inquiry
Cat.#:RANGAP1-13916MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RANGAP1 Protein
+Inquiry
Cat.#:RANGAP1-1384CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RANGAP1
+Inquiry
Cat.#:RANGAP1-2532HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RANGAP1 293 Cell Lysate
+Inquiry

Involved Pathway

RANGAP1 involved in several pathways and played different roles in them. We selected most pathways RANGAP1 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with RANGAP1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RNA transport
STRAP; SEH1L; RBM8A; UBE2IA; GEMIN8; NUP54; SUMO4; POP1; ELAC1; EIF3F

Protein Function

RANGAP1 has several biochemical functions, for example, GTPase activator activity, Ran GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RANGAP1 itself. We selected most functions RANGAP1 had, and list some proteins which have the same functions with RANGAP1. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein ACAP1; ARHGAP33; TBC1D16; ARHGDIB; RGS14; GIT1; TBC1D3C; LLGL2; NF1; DAB2IPB
Function Ran GTPase binding
Related Protein IPO11; TNPO2; XPO4; BIRC5; XPO1; IPO7; TNPO1; IPO13; XPO7; RANGRF
Function protein binding
Related Protein OSGIN1; HELT; BBS9; VEGFA; LCP2; PPP2R3A; PCNA; ZNF167; STOML1; RAD1
Function ubiquitin protein ligase binding
Related Protein BAG6; PRDX6; LRPPRC; DAXX; NEDD8; GPI1; OTUB1; GLMN; SLC22A18; TPI1

Interacting Protein

RANGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RANGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RANGAP1.
UBE2I; SUMO1; Ranbp2; NXF1; GNAI1; HLA-B; GABARAPL2

RANGAP1 Related Articles

Berndt, A; Wilkinson, KA; et al. In vivo characterization of the properties of SUM01-specific monobodies. BIOCHEMICAL JOURNAL 456:385-395(2013).
Tang, YA; Mackey, J; et al. Quantitative proteomic analysis of HER2 normal and overexpressing MCF-7 breast cancer cells revealed proteomic changes accompanied with HER2 gene amplification. JOURNAL OF PROTEOMICS 91:200-209(2013).