RANGAP1

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RANGAP1

Official Full Name Ran GTPase activating protein 1
Background RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
Synonyms RANGAP1; Ran GTPase activating protein 1; SD, segregation distorter homolog (Drosophila); ran GTPase-activating protein 1; Fug1; KIAA1835; segregation distortion; segregation distorter homolog; SD; MGC20266
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RANGAP1-12H Recombinant Human RANGAP1 Protein, His-tagged E.coli His
    Human RANGAP1-2532HCL Recombinant Human RANGAP1 293 Cell Lysate HEK293 N/A
    Human RANGAP1-30474TH Recombinant Human RANGAP1, His-tagged E.coli His
    Human RANGAP1-38H Recombinant Human RANGAP1 protein, GST-tagged Wheat Germ GST
    Human RANGAP1-42H Recombinant Human RANGAP1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human RANGAP1-682H Recombinant Human Ran GTPase Activating Protein 1, GST-tagged E.coli GST
    Mouse RANGAP1-13916M Recombinant Mouse RANGAP1 Protein Mammalian Cell His
    Chicken RANGAP1-1384C Recombinant Chicken RANGAP1 Mammalian Cell His

    RANGAP1 involved in several pathways and played different roles in them. We selected most pathways RANGAP1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with RANGAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport CLNS1A; NUP93; PABPC1A; EIF4G1A; MAGOH; EEF1A1B; UBE2IA; GEMIN4; RPP38; NUP37

    RANGAP1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by RANGAP1 itself. We selected most functions RANGAP1 had, and list some proteins which have the same functions with RANGAP1. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity ARHGDIG; RGS9B; CDC42EP4; RAP1GAP2B; LLGL2; RASA1; ARHGAP36; SIPA1L2; ASAP2; IQGAP3
    Ran GTPase binding IPO9; IPO5; TNPO2; RANBP3; NUP153; IPO11; IPO13; XPO1; XPOT; NXT1
    protein binding TYRO3; INHBB; UBE2W; NPAS2; MIIP; SPHK1; NINJ1; NFKBIL2; XRCC2; MAP3K14
    ubiquitin protein ligase binding TUBA1B; UBE2L3; SKI; ANKRD32; KDM4A; UBE2G1B; STX8; SPG20; UCHL1; XBP1

    RANGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RANGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RANGAP1.

    UBE2I; SUMO1; Ranbp2; NXF1; GNAI1; HLA-B; GABARAPL2

    Berndt, A; Wilkinson, KA; et al. In vivo characterization of the properties of SUM01-specific monobodies. BIOCHEMICAL JOURNAL 456:385-395(2013).
    Tang, YA; Mackey, J; et al. Quantitative proteomic analysis of HER2 normal and overexpressing MCF-7 breast cancer cells revealed proteomic changes accompanied with HER2 gene amplification. JOURNAL OF PROTEOMICS 91:200-209(2013).

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