Recombinant Human Ran GTPase Activating Protein 1, GST-tagged

• Cat.No.: RANGAP1-682H
• Product Overview: Recombinant human RanGAP1 produced inE. coliis fused to a GST-tag.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: RanGTPase-activating RanGAP1 was the first protein shown to be post-translationally modified with SUMO. In higher eukaryotes, the cellular localization of RanGAP1 is regulated by SUMOylation of its C-terminal domain. The target lysines of RanGAP1, as well as the C-terminus of mature SUMO-1, lie within mobile regions of the two proteins. Upon SUMOylation, RanGAP1 and SUMO-1 behave as "beads-on-a-string" joined by a flexible isopeptide tether and their structures and local dynamic features do not change significantly beyond the site of this covalent linkage.
• Source/Host: E. coli.
• Application: RanGAP1 acts as a very good control substrate for use in SUMOylation assays producing a product with a single SUMO modification as shown above.
• Long Term Storage: -80°C.

Gene Information

• Gene Name: RANGAP1 Ran GTPase activating protein 1 [ Homo sapiens ]
• Synonyms: Ran GTPase activating protein 1; SD; Fug1; KIAA1835; MGC20266; RANGAP1; ran GTPase-activating protein 1; segregation distortion; segregation distorter homolog; segregation distorter homolog (Drosophila); OTTHUMP00000198756; OTTHUMP00000198757; RanGAP1
• Gene ID: 5905
• mRNA Refseq: NM_002883
• Protein Refseq: NP_002874
• MIM: 602362
• UniProt ID: P46060
• Chromosome Location: 22q13
• Pathway: Cell Cycle, Mitotic
• Function: GTPase activator activity; Ran GTPase activator activity; protein binding