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RPS6KA1

  • Official Full Name

    ribosomal protein S6 kinase, 90kDa, polypeptide 1

  • Overview

    RSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).
  • Synonyms

    RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; ribosomal protein S6 kinase, 90kD, polypeptide 1; ribosomal protein S6 kinase alpha-1; HU 1; RSK; RSK1; RSK-1; p90S6K; p90RSK1; p90-RSK 1; MAPKAPK-1a; S6K-alpha 1; S6K-alpha-1; MAPKAP kinase 1a; ribosomal S6 kinase 1; MAPK-activated protein kinase 1a; ribosomal protein S6 kinase alpha 1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); HU-1; MAPKAPK1A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RPS6KA1-555H Active Recombinant Human RPS6KA1, GST-tagged Sf9 Insect Cell GST
Human RPS6KA1-550H Recombinant Human RPS6KA1 Mammalian Cell His
Human RPS6KA1-30110TH Recombinant Human RPS6KA1 N/A
Human RPS6KA1-2432H Recombinant Human RPS6KA1, GST-tagged E.coli GST 432-735aa
Human RPS6KA1-424H Recombinant Human RPS6KA1, GST-tagged, Active Sf9 Insect Cell GST
Human RPS6KA1-2162HCL Recombinant Human RPS6KA1 293 Cell Lysate HEK293 N/A
Human RPS6KA1-3984H Recombinant Human RPS6KA1 protein, His-tagged E.coli His 432-735 aa
Human RPS6KA1-1934H Recombinant Human RPS6KA1 protein, His & T7-tagged E.coli His/T7 Phe62~Tyr321 (Accession # Q15418)
Human RPS6KA1-4414H Recombinant Human RPS6KA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RPS6KA1-1148H Recombinant Human RPS6KA1 Protein (Q33-T353), Tag Free Insect Cell No tag Q33-T353
Human RPS6KA1-6201H Recombinant Human RPS6KA1 Protein (Phe62-Tyr321), N-His tagged E.coli N-His Phe62-Tyr321
Human RPS6KA1-4010H Recombinant Human RPS6KA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RPS6KA1-8403HF Active Recombinant Full Length Human RPS6KA1 Protein, GST-tagged Insect (sf21) GST 1-735
Human RPS6KA1-4010H-B Recombinant Human RPS6KA1 Protein Pre-coupled Magnetic Beads HEK293
Human RPS6KA1-1149H Recombinant Human RPS6KA1 Protein (Q33-T353), His tagged Insect Cell His Q33-T353
Human RPS6KA1-6200H Recombinant Human RPS6KA1 Protein (Met1-Leu735), C-His tagged Mammalian cells C-His Met1-Leu735
Mouse Rps6ka1-5609M Recombinant Mouse Rps6ka1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat RPS6KA1-5172R Recombinant Rat RPS6KA1 Protein Mammalian Cell His
Rat RPS6KA1-4831R-B Recombinant Rat RPS6KA1 Protein Pre-coupled Magnetic Beads HEK293
Rat RPS6KA1-4831R Recombinant Rat RPS6KA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RPS6KA1-4852Z Recombinant Zebrafish RPS6KA1 Mammalian Cell His
Chicken RPS6KA1-3760C Recombinant Chicken RPS6KA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RPS6KA1 Related Research Area
  • RPS6KA1 Related Signal Pathway

RPS6KA1 involved in several pathways and played different roles in them. We selected most pathways RPS6KA1 participated on our site, such as MAPK signaling pathway, Oocyte meiosis, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayDDIT3;HRAS;HSPA2;CDC42L2;PLA2G4F;ARRB1;FGF1A;RPS6KA3B;ACVR1C
Oocyte meiosisCUL1B;CAMK2D1;YWHABA;ITPR1;CPEB4;ADCY1A;CALM3;INS2;PPP2R5E
mTOR signaling pathwayPOLDIP3;BRAF;HIF1A;CAB39;RRAGCB;PIK3R3A;RPS6KA2;TSC1B;RPS6KB1
Long-term potentiationRPS6KA3;ATF4;GRM5;MAPK3;PPP1CB;PLCB1;NRAS;PLCB3;ITPR1
Neurotrophin signaling pathwayRAP1B;BAX;NGFRAP1;ATF4;FOXO3;CAMK2A;PIK3R2;PRDM4;SH2B3
Progesterone-mediated oocyte maturationCPEB3;AKT2L;RPS6KA3B;PRKACB;PRKACBA;RAF1B;PRKACA;ANAPC11;MAD1L1
Insulin resistancePTPN1;PIK3R1;MLXIPL;PRKAG3B;PRKAG3;PPP1CC;CREB3L3L;PPP2R4;PTPN11

RPS6KA1 has several biochemical functions, for example, ATP binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA1 itself. We selected most functions RPS6KA1 had, and list some proteins which have the same functions with RPS6KA1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCLPX;KSR1;CCT2;VPS4B;APAF1;MYHZ1.2;RBM4.3;ACVR2A;CAMK2D
cysteine-type endopeptidase inhibitor activity involved in apoptotic processRPS6KA3;BIRC3;TFAP2B;SNCA;PRDX3;NAIP1;XIAP;BIRC8;RPS6KA1
magnesium ion bindingATP10A;IMPAD1;NLRC4;PRPS1L1;PPM1AA;LHPP;PRPSAP1;PGM1;PRPS1A
protein bindingKDM2B;ECM1;MYO1C;PAPOLA;ZNHIT3;TTC25;MC3R;RB1CC1;COL6A2
protein serine/threonine kinase activityCSNK1G1;CLK3;TNK2;AURKB;CSNK1A1L;MAPK12;MAPK14B;LIMK1;MAP4K6
protein serine/threonine/tyrosine kinase activityRPS6KB1;DSTYK;DYRK2;PRKACA;PRKCG;MAP2K2;DYRK1AA;RPS6KA1;MAP2K1
ribosomal protein S6 kinase activityRPS6KA3;RPS6KA6;RPS6KA1;RPS6KB2;RPS6KA3A;RPS6KB1B;ALPK2;RPS6KA3B;RPS6KB1

RPS6KA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA1.

HSP90AB1; VASP; MAPT; CREB1; EIF4B; RPS6; xmd8-92; biotin_acyl-p_probe; YWHAB; ENAH; PPM1G; DDAH2; CFL1; GBP2; TTK; CCT4

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the impact of RPS6KA1 dysregulation on metabolic disorders, such as diabetes and obesity? 10/29/2020

Dysregulation of RPS6KA1 impacts metabolic processes, influencing conditions like diabetes and obesity.

What are the mechanisms by which RPS6KA1 modulates the cell cycle and apoptosis? 01/27/2020

RPS6KA1 modulates the cell cycle and apoptosis, playing a role in cell proliferation and programmed cell death.

How does RPS6KA1 influence neuronal development and function, especially in learning and memory processes? 07/20/2019

RPS6KA1 is involved in neuronal development and function, affecting processes like learning and memory.

How do genetic mutations in RPS6KA1 contribute to the development of certain cancers and other diseases? 06/24/2019

Genetic mutations in RPS6KA1 are linked to certain cancers and diseases, affecting its kinase activity and signaling functions.

How does RPS6KA1 interact with other kinases and signaling molecules in cellular signaling networks? 03/25/2019

RPS6KA1 interacts with various kinases and signaling molecules, integrating multiple cellular signaling pathways.

What role does RPS6KA1 play in cellular responses to stress, particularly in cancer cells? 09/16/2018

RPS6KA1 plays a crucial role in stress responses in cancer cells, influencing cell survival and adaptation mechanisms.

How does RPS6KA1 regulate protein synthesis and cell growth through the mTOR signaling pathway? 01/06/2018

RPS6KA1 regulates protein synthesis and cell growth by modulating the mTOR pathway, affecting ribosomal protein activity.

Customer Reviews (3)

Write a review
Reviews
07/10/2022

    Exceptional protein purification, highly recommended for research.

    06/02/2022

      Dependable mass spectrometry analysis; enhances our proteomics research.

      05/26/2020

        Quick and precise protein expression, a valuable service.

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