rps6ka1
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  • Official Full Name
  • ribosomal protein S6 kinase, 90kDa, polypeptide 1
  • Background
  • RSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).
  • Synonyms
  • RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; ribosomal protein S6 kinase, 90kD, polypeptide 1; ribosomal protein S6 kinase alpha-1; HU 1; RSK; RSK1; RSK-1; p90S6K; p90RSK1; p90-RSK 1; MAPKAPK-1a; S6K-alpha 1; S6K-alpha-1; MAPKAP kinase 1a; ribosomal S6 kinase 1; MAPK-activated protein kinase 1a; ribosomal protein S6 kinase alpha 1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); HU-1; MAPKAPK1A
Cat.#:RPS6KA1-1934HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS6KA1 protein, His & T7-tagged
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Cat.#:RPS6KA1-2432HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS6KA1, GST-tagged
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Cat.#:RPS6KA1-30110THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RPS6KA1
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Cat.#:RPS6KA1-424HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RPS6KA1, GST-tagged, Active
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Cat.#:RPS6KA1-550HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RPS6KA1
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Cat.#:RPS6KA1-555HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human RPS6KA1, GST-tagged
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Cat.#:RPS6KA1-5172RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RPS6KA1 Protein
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Cat.#:RPS6KA1-3760CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RPS6KA1
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Cat.#:RPS6KA1-4852ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RPS6KA1
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Cat.#:RPS6KA1-2162HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RPS6KA1 293 Cell Lysate
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Involved Pathway

RPS6KA1 involved in several pathways and played different roles in them. We selected most pathways RPS6KA1 participated on our site, such as MAPK signaling pathway, Oocyte meiosis, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
GADD45G; GADD45AA; ARRB2B; CACNA1B; LAMTOR3; GADD45AB; ATF4B1; FGF22; MAP2K4; MECOM
Oocyte meiosis
ANAPC1; CAMK2D1; RPS6KA3B; PRKACB; RPS6KA1; PRKACG; CTH1; ADCY1A; PPP1CA; PRKACAB
mTOR signaling pathway
INS1; ULK1; TSC1; PIK3R3; ULK3; CAB39; PTENA; DDIT4; EIF4EA; PIK3CG
Long-term potentiation
ATF4; RAP1A; ARAF; PPP1R1A; NRAS; CALM4; PPP1CB; PPP3CA; PPP3R1; RPS6KA3
Neurotrophin signaling pathway
NTRK2; RAF1; NTRK1; ZFP110; RPS6KA3; CDC42; PDPK1; TP53; NTF4; KRAS
Progesterone-mediated oocyte maturation
PIK3R5; AKT2; RPS6KA3; MAPK8B; CDK1; PDE3B; ADCY1A; PIK3R3A; IGF1RA; MAPK14B
Insulin resistance
PIK3CG; OGT.1; PPP1R3D; RPS6KA3A; INSB; INSRA; PIK3CD; SLC2A2; PIK3R1; CREB5

Protein Function

RPS6KA1 has several biochemical functions, for example, ATP binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA1 itself. We selected most functions RPS6KA1 had, and list some proteins which have the same functions with RPS6KA1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DDX19; RPS6KA6; PRKACA; SRC; DNAH5; DHX8; CLCN4; CLK4; PRKAG2; PRPF4BB
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein BIRC7; PRDX5; ARRB1; IGF1RA; CD27; DPEP1; LEF1; AVP; VIL1; BIRC2
Function magnesium ion binding
Related Protein PCK1; PGM5; PKM2; STK3; SRPK2; PSPH; NT5C3L; ATP8B5; NT5C1A; SPHK1
Function protein binding
Related Protein GDNF; TNFSF13B; ELK3; SNX9; GEMIN4; SNRPF; TSSK1; MAL2; MBP; KLK5
Function protein serine/threonine kinase activity
Related Protein TRIOA; MELK; ATM; MYO3B; AAK1; STK40; TGFBR1; CLK2; SGK2B; IRAK1
Function protein serine/threonine/tyrosine kinase activity
Related Protein CLK4; RPS6KA2; TNK2; ACVR2B; DYRK1B; TESK1; SGK1; TESK2; PRKAA2; AKT1
Function ribosomal protein S6 kinase activity
Related Protein RPS6KB1B; RPS6KA6; RPS6KA3A; RPS6KA1; ALPK2; RPS6KA3B; RPS6KB2; RPS6KA2; RPS6KA4; RPS6KB1

Interacting Protein

RPS6KA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA1.
HSP90AB1; VASP; MAPT; CREB1; EIF4B; RPS6; xmd8-92; biotin_acyl-p_probe; YWHAB; ENAH; PPM1G; DDAH2; CFL1; GBP2; TTK; CCT4