sod2
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  • Official Full Name
  • superoxide dismutase 2, mitochondrial
  • Background
  • This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SOD2; superoxide dismutase 2, mitochondrial; IPOB; MNSOD; MVCD6; superoxide dismutase [Mn], mitochondrial; indophenoloxidase B; Mn superoxide dismutase; mangano-superoxide dismutase; manganese-containing superoxide dismutase;
Cat.#:SOD2-355HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SOD2 Protein, His-tagged
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Cat.#:SOD2-1039HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD2
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Cat.#:SOD2-1636HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Superoxide Dismutase 2, Mitochondrial, GST-tagged
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Cat.#:SOD2-1181HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD2, None tagged
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Cat.#:SOD2-1568HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD2 protein, His-tagged
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Cat.#:SOD2-30343THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD2, His-tagged
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Cat.#:SOD2-31475THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD2
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Cat.#:SOD2-329HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD2 protein, His/MBP-tagged
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Cat.#:SOD2-330HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD2 protein, His/MBP-tagged
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Cat.#:SOD2-738HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SOD2, MYC-DDK-tagged
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Cat.#:SOD2-15750MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SOD2 Protein
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Cat.#:Sod2-56MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sod2, His-tagged
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Cat.#:Sod2-1569RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sod2 protein, His-tagged
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Cat.#:Sod2-34RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sod2, His-tagged
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Cat.#:SOD2-5667RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SOD2 Protein
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Cat.#:SOD2-957CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus SOD2 Protein, His-tagged
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Cat.#:SOD2-4406RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SOD2 Protein, His-tagged
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Cat.#:SOD2-5785CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SOD2
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Cat.#:SOD2-10339ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SOD2
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Cat.#:SOD2-1574HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SOD2 293 Cell Lysate
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Cat.#:SOD2-1575HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SOD2 293 Cell Lysate
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Involved Pathway

SOD2 involved in several pathways and played different roles in them. We selected most pathways SOD2 participated on our site, such as FoxO signaling pathway, Peroxisome, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
RAG2; GRB2B; BCL6A; PRKAB1; SGK1; PRKAA2; INSR; HOMER3; MAPK11; FOXO1
Peroxisome
PEX5L; PEX3; IDH1; PEX10; ACSL3; PEX11C; GNPAT; ABCD4; PEX7; PEX1
Huntingtons disease
COX6A2; ITPR1; COX7C; PPARGC1A; DNAH11; RCOR1; COX6B2; PLCB1; NDUFB1; COX8A

Protein Function

SOD2 has several biochemical functions, for example, identical protein binding, manganese ion binding, superoxide dismutase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOD2 itself. We selected most functions SOD2 had, and list some proteins which have the same functions with SOD2. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein DAPK3; TTN; COL1A1; FNBP1; SQSTM1; CRYAB; DES; MMP9; RNF4; NFKBIA
Function manganese ion binding
Related Protein PPM1A; PPM1B; CDIPT; B4GALT1; MRE11A; PPM1M; DYRK2; PPEF1; NUDT7; PPM1AA
Function superoxide dismutase activity
Related Protein SOD3A; SOD1; CCS; PRNPA; NQO1; SOD2

Interacting Protein

SOD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOD2.
AURKA; RIPK2; SMARCA5; EIF1B; CST4; CST1; AMY1B; P4HB; MYH8; HSP90B1; MCC; MPG; HLA-B; VHL; RPL21; SMARCA2; ARF6; SCRN1

SOD2 Related Articles

Kang, PT; Chen, CL; et al. Increased mitochondrial prooxidant activity mediates up-regulation of Complex I S-glutathionylation via protein thiyl radical in the murine heart of eNOS(-/-). FREE RADICAL BIOLOGY AND MEDICINE 79:56-68(2015).
Kang, PT; Chen, CL; et al. BCNU-induced gR2 DEFECT mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium. BIOCHEMICAL PHARMACOLOGY 89:490-502(2014).