|Official Full Name||superoxide dismutase 2, mitochondrial|
|Background||This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]|
|Synonyms||SOD2; superoxide dismutase 2, mitochondrial; IPOB; MNSOD; MVCD6; superoxide dismutase [Mn], mitochondrial; indophenoloxidase B; Mn superoxide dismutase; mangano-superoxide dismutase; manganese-containing superoxide dismutase;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
SOD2 involved in several pathways and played different roles in them. We selected most pathways SOD2 participated on our site, such as FoxO signaling pathway, Peroxisome, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|FoxO signaling pathway||CDKN2B; MAP2K2; PCK2; PRKAB1; MAPK14B; EP300; PLK1; FOXG1A; GADD45AA; PLK4|
|Peroxisome||ACSL1B; AGPS; NUDT12; SLC25A17; PRDX1; ACOX3; ECH1; ABCD3A; PMVK; ABCD3|
|Huntingtons disease||TP53; GRM5; NDUFB7; ATP5D; NDUFB9; NDUFB3; NDUFB10; HAP1; SP1; ATP5C1|
SOD2 has several biochemical functions, for example, identical protein binding, manganese ion binding, superoxide dismutase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOD2 itself. We selected most functions SOD2 had, and list some proteins which have the same functions with SOD2. You can find most of the proteins on our site.
|identical protein binding||ADORA2A; CLDN17; ZDHHC17; MICU1; NUFIP1; IGF2R; Serpina1c; PVRL2; SOX10; THBS1|
|manganese ion binding||PPM1AB; WRN; PIM1; PAPOLA; XPNPEP1; PPEF1; HMGCL; NPEPL1; PPM1AA; B4GALT7|
|superoxide dismutase activity||SOD3A; SOD1; CCS; PRNPA; NQO1; SOD2|
SOD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOD2.
AURKA; RIPK2; SMARCA5; EIF1B; CST4; CST1; AMY1B; P4HB; MYH8; HSP90B1; MCC; MPG; HLA-B; VHL; RPL21; SMARCA2; ARF6; SCRN1