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Official Full Name superoxide dismutase 2, mitochondrial
Background This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Synonyms SOD2; superoxide dismutase 2, mitochondrial; IPOB; MNSOD; MVCD6; superoxide dismutase [Mn], mitochondrial; indophenoloxidase B; Mn superoxide dismutase; mangano-superoxide dismutase; manganese-containing superoxide dismutase;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SOD2-06H Recombinant Human SOD2 Protein E.coli
    Human SOD2-2681H Recombinant Human SOD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SOD2-355H Recombinant Human SOD2 protein, His-tagged E.coli His
    Mouse Sod2-6041M Recombinant Mouse Sod2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Sod2-7342M Recombinant Mouse Sod2 Protein, His-tagged E.coli His
    Human SOD2-1039H Recombinant Human SOD2 E.coli N/A
    Human SOD2-1181H Recombinant Human SOD2, None tagged E.coli N/A
    Human SOD2-1568H Recombinant Human SOD2 protein, His-tagged E.coli His
    Human SOD2-1574HCL Recombinant Human SOD2 293 Cell Lysate HEK293 N/A
    Human SOD2-1575HCL Recombinant Human SOD2 293 Cell Lysate HEK293 N/A
    Human SOD2-1636H Recombinant Human Superoxide Dismutase 2, Mitochondrial, GST-tagged E.coli GST
    Human SOD2-30343TH Recombinant Human SOD2, His-tagged E.coli His
    Human SOD2-31475TH Recombinant Human SOD2 E.coli N/A
    Human SOD2-329H Recombinant Human SOD2 protein, His/MBP-tagged E.coli His/MBP
    Human SOD2-330H Recombinant Human SOD2 protein, His/MBP-tagged E.coli His/MBP
    Human SOD2-738H Recombinant Human SOD2, MYC-DDK-tagged HEK293 Myc/DDK
    Mouse SOD2-15750M Recombinant Mouse SOD2 Protein Mammalian Cell His
    Mouse Sod2-56M Recombinant Mouse Sod2, His-tagged E.coli His
    Rat Sod2-1569R Recombinant Rat Sod2 protein, His-tagged E.coli His
    Rat Sod2-34R Recombinant Rat Sod2, His-tagged E.coli His
    Rat SOD2-5667R Recombinant Rat SOD2 Protein Mammalian Cell His
    Cynomolgus Monkey SOD2-957C Recombinant Cynomolgus SOD2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque SOD2-4406R Recombinant Rhesus monkey SOD2 Protein, His-tagged Mammalian Cell His
    Chicken SOD2-5785C Recombinant Chicken SOD2 Mammalian Cell His
    Zebrafish SOD2-10339Z Recombinant Zebrafish SOD2 Mammalian Cell His

    SOD2 involved in several pathways and played different roles in them. We selected most pathways SOD2 participated on our site, such as FoxO signaling pathway, Peroxisome, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway CDKN2B; MAP2K2; PCK2; PRKAB1; MAPK14B; EP300; PLK1; FOXG1A; GADD45AA; PLK4
    Peroxisome ACSL1B; AGPS; NUDT12; SLC25A17; PRDX1; ACOX3; ECH1; ABCD3A; PMVK; ABCD3
    Huntingtons disease TP53; GRM5; NDUFB7; ATP5D; NDUFB9; NDUFB3; NDUFB10; HAP1; SP1; ATP5C1

    SOD2 has several biochemical functions, for example, identical protein binding, manganese ion binding, superoxide dismutase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOD2 itself. We selected most functions SOD2 had, and list some proteins which have the same functions with SOD2. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding ADORA2A; CLDN17; ZDHHC17; MICU1; NUFIP1; IGF2R; Serpina1c; PVRL2; SOX10; THBS1
    manganese ion binding PPM1AB; WRN; PIM1; PAPOLA; XPNPEP1; PPEF1; HMGCL; NPEPL1; PPM1AA; B4GALT7
    superoxide dismutase activity SOD3A; SOD1; CCS; PRNPA; NQO1; SOD2

    SOD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOD2.


    Kang, PT; Chen, CL; et al. Increased mitochondrial prooxidant activity mediates up-regulation of Complex I S-glutathionylation via protein thiyl radical in the murine heart of eNOS(-/-). FREE RADICAL BIOLOGY AND MEDICINE 79:56-68(2015).
    Kang, PT; Chen, CL; et al. BCNU-induced gR2 DEFECT mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium. BIOCHEMICAL PHARMACOLOGY 89:490-502(2014).

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