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TFF3

  • Official Full Name

    trefoil factor 3 (intestinal)

  • Overview

    Trefoil factor 3 is a protein that in humans is encoded by the TFF3 gene. Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
  • Synonyms

    TFF3; trefoil factor 3 (intestinal); trefoil factor 3; HITF; ITF; polypeptide P1.B; P1B; TFI;

  • Recombinant Proteins
  • Cattle
  • Dog
  • Human
  • Mouse
  • Pig
  • Rat
  • E.coli
  • HEK293
  • Human
  • Yeast
  • Flag
  • GST
  • His
  • His|Fc
  • His|GST
  • His|MBP
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TFF3-652H Recombinant Human TFF3 protein E.coli N/A 59
Human TFF3-973H Recombinant Human Trefoil Factor 3 E.coli N/A
Human TFF3-1046H Recombinant Human TFF3, His-tagged E.coli His
Human TFF3-4169H Recombinant Human Trefoil Factor-3 His Tag Human His
Human TFF3-3204H Recombinant Human TFF3, GST-tagged E.coli GST 1-80aa
Human TFF3-1760H Recombinant Human TFF3 protein, His & GST-tagged E.coli His/GST Met22~Phe80
Human TFF3-540H Recombinant Human TFF3 Protein, His-tagged HEK293 His Met1-Phe94
Human TFF3-6422H Recombinant Human TFF3 Protein (Met22-Val80), N-GST tagged E.coli N-GST Met22-Val80
Human TFF3-5527H Recombinant Human TFF3 protein, His-tagged Yeast His 29-80aa
Human TFF3-3564H Recombinant Human TFF3 protein, GST-tagged E.coli GST 29-80aa
Human TFF3-112T Active Recombinant Human TFF3 Protein (59 aa) E.coli 59
Mouse TFF3-16692M Recombinant Mouse Tff3 protein, His/Fc-tagged HEK293 His/Fc
Mouse Tff3-1761M Recombinant Mouse Tff3 protein, His & GST-tagged E.coli His/GST Ala23~Phe81 (Accession # Q62395)
Mouse Tff3-1762M Recombinant Mouse Tff3 protein, His & MBP-tagged E.coli His/MBP Ala23~Phe81 (Accession # Q62395)
Rat Tff3-1765R Recombinant Rat Tff3 protein, GST-tagged E.coli GST Gln23~Phe81 (Accession # Q03191)
Rat TFF3-6030R Recombinant Rat Tff3 protein, Flag-tagged E.coli Flag 68 amino acid residues
Dog TFF3-1759D Recombinant Dog TFF3 protein, His-tagged E.coli His Tyr24~Phe80
Cattle TFF3-1758C Recombinant Cattle TFF3 protein, His & GST-tagged E.coli His/GST Gly23~Phe81 (Accession # A8YXX7)
Pig TFF3-1763P Recombinant Pig TFF3 protein, His & GST-tagged E.coli His/GST Gly22~Phe80 (Accession # Q29183),
Pig TFF3-1764P Recombinant Pig TFF3 protein, His & MBP-tagged E.coli His/MBP Gly22~Phe80 (Accession # Q29183)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TFF3 Related Articles

TFF3 involved in several pathways and played different roles in them. We selected most pathways TFF3 participated on our site, such as HIF-1-alpha transcription factor network, IL4-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HIF-1-alpha transcription factor networkENG;NPM1;EGLN3;CITED2;PLIN2;ADM;CP;NDRG1;TFF3
IL4-mediated signaling eventsCCL26;TFF3;RETNLB;IRF4;IgG3;DOK2;PARP14;NIPAL1;EGR2

TFF3 has several biochemical functions, for example, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFF3 itself. We selected most functions TFF3 had, and list some proteins which have the same functions with TFF3. You can find most of the proteins on our site.

Function Related Protein
molecular_functionNPTX2;ASPSCR1;TMEM179;L3MBTL3;ARL6IP5B;HSPA12A;GM4307;KRT28;UBALD1B
protein bindingEXO1;SKAP2;PSMD2;MAP3K3;ZC3HAV1;USP46;UBA6;NUDT21;IDE

TFF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TFF3.

SGTA; PCBD1

Davidov, T; Nagar, M; et al. Carbonic anhydrase 4 and crystallin alpha-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. JOURNAL OF SURGICAL RESEARCH 190:565-574(2014).
Yue, L; Xiang, JY; et al. Inhibition of ErbB-2 induces TFF3 downregulation in breast cancer cell lines. APMIS 122:628-635(2014).
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