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Recombinant Rat Tff3 protein, Flag-tagged

Cat.No. : TFF3-6030R
Product Overview : Recombinant Rat Tff3 fused with a 9 a.a C-terminal fusion of Flag-Tag (1 aa N-terminal+8 aa C-terminal) was expressed in E. coli.
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Description : Proteins of the TFF family are characterized by obtaining a minimum of 1 copy of the trefoil motif, a 40-amino acid domain that contains 3 conserved disulfides. Trefoil Factors are stable secretory proteins expressed in gastrointestinal mucosa which protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium.TFF2 inhibits gastric acid motility & secretion. TFF2 stabilizes glycoproteins in the mucus gel through interactions with carbohydrate side chains. TFF3 induces ciliogenesis and promotes airway epithelial ciliated cell differentiation, relatively through an epidermal growth factor receptor-dependent pathway. TFF3 overexpression is crucial for progression in mouse and human hepatocellular carcinogenesis. TFF-3 is normally expressed in hepatocellular carcinoma and its expression associates with tumor grade.
Source : E. coli
Species : Rat
Tag : Flag
Form : TFF3 protein filtered (0.4µm) and lyophilized in 0.5mg/ml in 20mM TRIS and 50mM NaCl, pH 7.5.
Molecular Mass : 7.7kDa
Protein length : 68 amino acid residues
AA Sequence : MQEFVGLSPS QCMVPANVRV DCGYPTVTSE QCNNRGCCFD SSIPNVPWCF KPLQETECT F DYKDDDDK.
Purity : Purity as determined by densitometric image analysis is greater than 95%.
Stability : Store lyophilized protein at -20 centigrade. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 centigrade for a limited period of time; it does not show any change after two weeks at 4 centigrade.
Reconstitution : It is recommended to add 200µl deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Gene Name : Tff3 trefoil factor 3, intestinal [ Rattus norvegicus ]
Official Symbol : Tff3
Synonyms : TFF3; trefoil factor 3, intestinal; trefoil factor 3; rITF; rP1.B; polypeptide P1.B; intestinal trefoil factor; Trefoil factor (intestinal); ITF; TREFOIL;
Gene ID : 25563
mRNA Refseq : NM_013042
Protein Refseq : NP_037174
UniProt ID : Q62395
Chromosome Location : 17 A3.3; 17 15.8 cM

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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