tgfb3
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  • Official Full Name
  • transforming growth factor, beta 3
  • Background
  • This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1.
  • Synonyms
  • TGFB3; transforming growth factor, beta 3; ARVD; FLJ16571; TGF-beta3; transforming growth factor beta-3; TGF-beta-3; MGC105479; MGC118722; TGF beta 3; TGF beta3; TGFB 3; TGFB3_HUMAN; transforming growth factor beta 3; OTTHUMP00000246179; OTTHUMP00000246180
Cat.#:TGFB3-349HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 3
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Cat.#:TGFB3-376HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 3
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Cat.#:TGFB3-65HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transforming Growth Ffactor, Beta 3
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Cat.#:TGFB3-017HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB3 Protein
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Cat.#:TGFB3-018HTag:
Source (Host):CHO cellSpecies:Human
Product nameRecombinant Human TGFB3 Protein
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Cat.#:TGFB3-126HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human TGFB3
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Cat.#:TGFB3-128HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human TGFB3 Active
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Cat.#:TGFB3-12HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB3, His-tagged
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Cat.#:TGFB3-1571HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human TGFB3, Active
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Cat.#:TGFB3-468HTag:N/A
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 3, Dimeric Form
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Cat.#:TGFB3-6038RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tgfb3 protein, His-tagged
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Cat.#:TGFB3-4688RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TGFB3 Protein, His-tagged
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Cat.#:TGFB3-7004CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TGFB3
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Cat.#:TGFB3-9736ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TGFB3
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Cat.#:TGFB3-2003CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle TGFB3 protein, His & GST-tagged
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Cat.#:TGFB3-2004PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig TGFB3 protein, His & T7-tagged
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Cat.#:TGFB3-598HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 3
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Cat.#:TGFB3-006NTag:N/A
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 3, Dimeric Form
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Cat.#:TGFB3-007NTag:N/A
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 3, Monomeric Form
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Cat.#:TGFB3-1118HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TGFB3 293 Cell Lysate
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Cat.#:TGFB3-104HGTag:
Source (Host):Insect cellSpecies:Human
Product nameGMP Recombinant Human TGFB3 Protein
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Cat.#:TGFB3-31HTag:
Source (Host):Species:Human
Product nameHuman Transforming Growth Factor-BETA 3 Reference standard
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Involved Pathway

TGFB3 involved in several pathways and played different roles in them. We selected most pathways TGFB3 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
BDNF; RAP1A; CACNA2D2; RPS6KA4; FGF11; STK3; NTRK2; TRAF2; STK4; CACNA1BA
Cytokine-cytokine receptor interaction
TGFBR1B; NGFR; IL6ST; THPO; LIFRA; IL1A; CSF1RA; IFNG1-2; Pdgfa&Pdgfb; CD40LG
FoxO signaling pathway
IGF1RA; RAF1; STK11; IL6; NRAS; FBXO25; CCNB3; TGFBR1; PRKAA1; TGFBR2
Cell cycle
YWHAH; MYC; NCAPD2; CDKN1BB; MYBL2; NUDC; SDCCAG8; CDK7; PCM1; DCTN1A
Endocytosis
SMURF2; HSP70; ERBB3B; WIPF2B; GRK1; EGFRA; CHMP6; GRK1B; RAB5AB; WASB
TGF-beta signaling pathway
CHD; SMAD6; RBX1; AMH; IFNG1-2; BMPR1AA; RPS6KB1B; ACVR1L; FST; AMHR2
Hippo signaling pathway
PPP2R2B; WNT7B; WTIP; FRMD6; BMP5; DLG1; TCF7L2; SCRIB; BMP2; WWC1
Leishmaniasis
NFKB1; FOS; H2-AA; MAP3K7; MYD88; HLA-DMB; TGFB1; IRAK1; CYBA; ITGB2
Chagas disease (American trypanosomiasis)
NFKB1; SERPINE1; FADD; PPP2R1B; PPP2CA; Ccl12; IRAK1; IL12A; CD3E; CD3E; CD3D
Malaria
COMP; CSF3; GYPA; HBB-B2; CD81; SELE; GYPC; TGFB1; PECAM1; LRP1
Toxoplasmosis
GNAI1; PDPK1; TLR4; IKBKG; STAT3; PIK3R1; SOCS1; LAMA5; NOS2; IRAK1
Amoebiasis
LAMA3; PIK3R5; SERPINB2; CD1d1; PRKCA; IL-8; IL12A; IL1R2; LAMA5; PIK3R2
Tuberculosis
HLA-DMA; HLA-DPB1; EP300; PPP3CC; IRAK2; LSP1; FCGR1; CASP9; TLR4; CYCS
Hepatitis B
NRAS; TBK1; CREB3L1; MYD88; PIK3R3; CASP10; SRC; IFNA10; EP300; STAT1
HTLV-I infection
EGR2; PIK3R1; ELK1; CD3E; IKBKG; CREM; TBP; WNT1; POLE2; MAP3K3
Pathways in cancer
FGF18; GNA11; HGF; DAPK3; BAD; RAF1; TRAF3; FGF17; NFKB2; PLD1
Colorectal cancer
TGFBR1; LEF1; CYCS; APPL1; PIK3R3; TCF7; SMAD2; RAC1; PIK3CD; PIK3R1
Renal cell carcinoma
ETS1; MET; HIF1A; TGFB1; PIK3R1; BRAF; ARAF; FH; EGLN2; RAP1B
Pancreatic cancer
TGFB3; IKBKG; PIK3CB; BCL2L1; PIK3R1; TGFBR2; TGFB1; PIK3CA; BRAF; VEGFA
Chronic myeloid leukemia
MAPK1; HDAC1; SHC4; TGFB3; TGFBR2; BCL2L1; IKBKB; PIK3R1; CDK6; SMAD4
Inflammatory bowel disease (IBD)
IL18RAP; HLA-DQA1; IL23; Il23a; Il12b; GATA3; IL22; RORA; IL17F; Il23a; IL21
Rheumatoid arthritis
ATP6V1H; CCL3L3; VEGFA; TGFB1; TNFSF11; HLA-DMA; IL18; ATP6V1E1; HLA-DQA2; MMP1A
Hypertrophic cardiomyopathy (HCM)
TNNC1; LAMA2; CACNB4; ITGA10; TGFB3; CACNB1; ITGAV; SLC8A1; ITGA4; PRKAG1
Dilated cardiomyopathy
MYH7; SGCD; ITGB4; SGCB; ITGA10; CACNA2D4; Itga10&Itgb1; ITGA1; TNNI3; TPM2

Protein Function

TGFB3 has several biochemical functions, for example, cytokine activity, growth factor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFB3 itself. We selected most functions TGFB3 had, and list some proteins which have the same functions with TGFB3. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein NDR1; EDN1; IL7; SCG2; GDF6B; BMP7A; SECTM1; IFNA8; AIMP1; CCL6
Function growth factor activity
Related Protein HBEGFB; CXCL12; Pdgfa&Pdgfb; AMBN; FGF10B; IGF1; LACRT; GDF10B; WISP3; DKK1
Function identical protein binding
Related Protein AXIN1; GOT1L1; PSMA7; LUC7L; DPP9; CALHM1; KDM6A; TRIM55; CAV1; LZTFL1
Function protein binding
Related Protein MAP2K6; NAA35; CACNA1SB; CTTN; TOMM20; MST1; FBXO9; MLLT1; FAM188A; GPA33
Function protein heterodimerization activity
Related Protein BNIP3L; H2AFVA; ALG2; UNC13A; THRA; PIK3R1; POLA2; SYCP2; HIST1H3F; KCNA3
Function transforming growth factor beta binding
Related Protein ACVRL1; ACVR1; CD109; TGFB3; THBS1; LTBP1; ENG; HYAL2; ITGAV; TGFBR3
Function type I transforming growth factor beta receptor binding
Related Protein TGFB1; ENG; TGFBR2; SMAD2; SNX25; SMAD7; FKBP1A; SMAD6; TGFB3
Function type II transforming growth factor beta receptor binding
Related Protein TGFB1A; TGFB3; TGFBR1; ENG; BAMBI; TGFBR3; TGFB2; TGFB1
Function type III transforming growth factor beta receptor binding
Related Protein TGFB3; TGFBR2; TGFB2; TGFB1

Interacting Protein

TGFB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFB3.
TGFBR2; TGFBR1; TGFBR3; CHMP2A; SDC4; CCL20

TGFB3 Related Articles

Petra, H; Eva, H; et al. Molecular Profiling of Acute and Chronic Rejections of Renal Allografts. CLINICAL & DEVELOPMENTAL IMMUNOLOGY :-(2013).
Le, M; Naridze, R; et al. Transforming Growth Factor Beta 3 Is Required for Excisional Wound Repair In Vivo. PLOS ONE 7:-(2012).