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Official Full Name transforming growth factor, beta receptor 1
Background The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta,;transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine;protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple;transcript variants encoding different isoforms have been found for this gene.
Synonyms TGFBR1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kD); TGF-beta receptor type-1; activin A receptor type II like kinase; 53kDa; ACVRLK4; ALK 5; tbetaR-I; TGF-beta re
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • Fc
    • Fc Chimera
    • His
    • Flag
    • GST
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TGFBR1-001HCL Recombinant Human TGFBR1 cell lysate Insect Cell N/A
    Human TGFBR1-1495H Recombinant Human TGFBR1 (Active), GST-tagged Sf9 Insect Cell GST
    Human TGFBR1-1499H Recombinant Human TGFBR1, GST-tagged Sf9 Insect Cell GST
    Human TGFBR1-1543H Recombinant Human TGFBR1, Unactive, GST-tagged Sf9 Insect Cell GST
    Human TGFBR1-2346H Recombinant Human TGFBR1, Fc-His tagged Human Cell Fc/His
    Human TGFBR1-2482HCL Recombinant Human TGFBR1 cell lysate Human Cell N/A
    Human TGFBR1-31137TH Recombinant Human TGFBR1 Sf9 Insect Cell N/A
    Human TGFBR1-31138TH Recombinant Human TGFBR1 N/A
    Human TGFBR1-39H Recombinant Human TGFBR1 (T204D), GST-tagged Sf9 Insect Cell GST
    Human TGFBR1-5523H Recombinant Human Transforming Growth Factor, Beta Receptor 1 Sf9 Insect Cell N/A
    Human TGFBR1-589H Recombinant Human TGFBR1 Protein, His-tagged E.coli His
    Human TGFBR1-695H Recombinant Human TGFBR1, Fc-tagged, Biotinylated Human Cell Fc
    Human TGFBR1-696H Recombinant Human TGFBR1, Fc-tagged Human Cell Fc
    Human TGFBR1-701H Recombinant Human TGFBR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TGFBR1-716H Recombinant Human TGFBR1, GST-His Sf9 Insect Cell GST
    Human TGFBR1-83H Recombinant Human TGFBR1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human TGFBR1-8656H Recombinant Human TGFBR1, His-GST tagged Insect Cell His
    Mouse Tgfbr1-1777M Recombinant Mouse Tgfbr1 protein, His-tagged Insect Cell His
    Mouse Tgfbr1-439M Recombinant Mouse Tgfbr1, Fc Chimera Sf21 Insect Cell Fc Chimera
    Chicken TGFBR1-5819C Recombinant Chicken TGFBR1 Mammalian Cell His

    TGFBR1 involved in several pathways and played different roles in them. We selected most pathways TGFBR1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PRKCBA; MEF2C; FGF6A; CACNA2D4; FGFR2; MAP2K4; CASP3B; STK4; Pdgfa&Pdgfb; ARRB2B
    Cytokine-cytokine receptor interaction CXCL14; IL28RA; TNFRSF6B; BMP2; VEGFB; IL25; CSF1RA; TGFB3; CCL27B; MET
    FoxO signaling pathway PRKAG2; KLF2; FOXO1A; SGK3; TGFBR1A; PIK3CA; IGF1; SOS1; PIK3CG; FOXO1B
    Endocytosis IGF1R; ARPC5A; VTA1; PARD6A; ADRB2A; SNX2; CXCR2; AGAP2; HSPA6; RAB7A
    TGF-beta signaling pathway IFNG1-2; RHOAA; SPAW; BMP7; INHBAB; TFDP1; BMP6; LEFTY2; SMAD3A; TGFB2
    Osteoclast differentiation CYBB; TNFRSF1A; TGFB2; IL1A; ACP5; MAPK13; TAB2; FHL2; NCF4; TEC
    Hippo signaling pathway MPP5; APC; WNT3A; TEAD3; GDF7; TGFB1; WNT1; PPP2R2C; TCF7; WWTR1
    Adherens junction PTPRM; PTPRB; NLK1; ACTN2B; CSNK2A2; IGF1R; WAS; RAC2; EGFRA; SMAD2
    Chagas disease (American trypanosomiasis) CD3G; TICAM1; PPP2CA; CXCL8; NFKB1; FOS; GNAS; PIK3R1; IKBKB; PIK3R3
    Hepatitis B IL6; TRP53; NFATC4; PCNA; CCNA1; BAX; STAT1; IFNA4; BIRC5; IFNA12
    HTLV-I infection POLD4; BUB3; FZD8; APC; PPP3CC; XIAP; ANAPC11; WNT8A; SPI1; SLC2A1
    Pathways in cancer BID; GLI1; MSH2; CCNE1; HIF1A; BCR; SLC2A1; MAP2K2; NFKB1; LAMB4
    Colorectal cancer MSH3; AXIN1; CYCS; TCF7; MSH2; RHOA; RAF1; MLH1; RAC1; MAP2K1
    Pancreatic cancer RALB; TGFA; RAC2; AKT2; RAD51; TGFB3; RALBP1; PLD1; TRP53; IKBKG
    Chronic myeloid leukemia TGFB2; TGFBR2; CDK6; MAPK3; TRP53; TGFB1; PIK3R5; MECOM; PIK3CD; STAT5B

    TGFBR1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR1 itself. We selected most functions TGFBR1 had, and list some proteins which have the same functions with TGFBR1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ATP5A1; PMVK; P2RX7; ATP6V1B2; AK4; CBWD1; Adcy4; MYO1A; TGFBR2; NUAK1
    contributes_to growth factor binding TGFBR1; IL6ST; ERBB2; ACVR1B
    metal ion binding GDPD3; CALM4; CAR7; ZNF192; ZIC3; KDM8; ME2; ADAMTS7; EGR4; ENTPD7
    protein binding PRPF4B; TFDP2; CTDP1; AGTR1A; ASMTL; CD4; TGFBR3; DHX36; pab1; MRAP2
    protein kinase activity NTRK2B; CLK4B; STK4; MAP2K2A; CCL5; IRAK4; CSNK1A1; NRBP2; ACVR2AA; NPR2
    protein serine/threonine kinase activity DYRK2; SIK2A; ACVR1L; KALRN; GRK1B; CAMKK1A; LMTK3; MAP2K7; ULK3; CDKL5
    receptor signaling protein activity KLK1B3; IL4R; ARAF; CD19; BAG4; PLCG1; NGF; CD3E; PLCE1; DOK1
    receptor signaling protein serine/threonine kinase activity STK24A; BMPR1AA; ALPK2; NEK4; BMPR1A; OXSR1B; BMPR2; PANK1A; ACVR1; TGFBR2
    transforming growth factor beta binding VASN; TGFBR1; ACVR1; ACVRL1; TGFBR3; HYAL2; ENG; CD109; TGFB3; THBS1
    contributes_to transforming growth factor beta binding TGFBR2; TGFBR3; TGFBR1; ENG
    transforming growth factor beta receptor activity, type I BMPR1B; ACVR1; TGFBR1
    transforming growth factor beta-activated receptor activity BMPR2B; TGFBR3; ENG; TGFBR2; BMPR2A; TGFBR1; ACVRL1; LTBP1
    contributes_to transforming growth factor beta-activated receptor activity TGFBR1
    type II transforming growth factor beta receptor binding TGFBR1; ENG; TGFBR3; TGFB2; TGFB3; BAMBI; TGFB1A; TGFB1

    TGFBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR1.

    q99ib8-pro_0000045599; TGFB3; FKBP1A; YWHAZ; TGFB1; Rnf5


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