tgfbr1
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  • Official Full Name
  • transforming growth factor, beta receptor 1
  • Background
  • The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta,;transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine;protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple;transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • TGFBR1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kD); TGF-beta receptor type-1; activin A receptor type II like kinase; 53kDa; ACVRLK4; ALK 5; tbetaR-I; TGF-beta re
Cat.#:TGFBR1-5523HTag:N/A
Source (Host):Sf9 insect cellsSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta Receptor 1
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Cat.#:TGFBR1-701HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR1 Protein, MYC/DDK-tagged
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Cat.#:TGFBR1-1499HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TGFBR1, GST-tagged
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Cat.#:TGFBR1-2346HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR1, Fc-His tagged
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Cat.#:TGFBR1-31137THTag:
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TGFBR1
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Cat.#:TGFBR1-31138THTag:
Source (Host):Species:Human
Product nameRecombinant Human TGFBR1
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Cat.#:TGFBR1-39HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TGFBR1 (T204D), GST-tagged
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Cat.#:TGFBR1-589HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFBR1 Protein, His-tagged
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Cat.#:TGFBR1-695HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TGFBR1, Fc-tagged, Biotinylated
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Cat.#:TGFBR1-696HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TGFBR1, Fc-tagged
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Cat.#:TGFBR1-716HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TGFBR1, GST-His
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Cat.#:TGFBR1-83HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human TGFBR1 protein, Flag-tagged, Biotinylated
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Cat.#:TGFBR1-8656HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TGFBR1, His-GST tagged
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Cat.#:Tgfbr1-1777MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Tgfbr1 protein, His-tagged
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Cat.#:Tgfbr1-439MTag:Fc Chimera
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Tgfbr1, Fc Chimera
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Cat.#:TGFBR1-5819CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TGFBR1
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Cat.#:TGFBR1-1495HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TGFBR1 (Active), GST-tagged
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Cat.#:TGFBR1-1543HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TGFBR1, Unactive, GST-tagged
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Cat.#:TGFBR1-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TGFBR1 cell lysate
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Cat.#:TGFBR1-2482HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR1 cell lysate
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Involved Pathway

TGFBR1 involved in several pathways and played different roles in them. We selected most pathways TGFBR1 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
TGFB1; CACNG7A; ELK1; TGFB1A; MEF2CB; MAPK8IP3; STK4; AKT2L; PPM1NB; GADD45B
Cytokine-cytokine receptor interaction
CSF1RA; IL11RA2; CCL11; ACVR2B; IL9R; CSF2; IL3RA; CCL16; IL6ST; IFNPHI1
FoxO signaling pathway
INSR; HOMER1B; RAG2; PIK3R3A; HRASB; FOXO3B; MAPK8; BCL6A; AKT2; NLK1
Endocytosis
ARRB2B; SNX1; ARF6B; PDCD6IP; RAB22A; STAMBPB; CAV3; TGFBR2; SMAD3; PIP5K1BA
TGF-beta signaling pathway
ZFYVE16; TFDP1; CUL1A; RHOAB; BAMBI; BMPR1AA; BMP2B; PITX2; ID2; BAMBIA
Osteoclast differentiation
LILRA2; SIRPA; PIK3R5; MAPK13; NFATC1; NFKB2; STAT2; NOX1; CYBB; AKT2
Hippo signaling pathway
CCND2; SOX2; BMPR2; TEAD2; CRB2; LATS2; PRKCI; SAV1; TGFBR1; PPP1CA
Adherens junction
NLK; WASF1; LEF1; WASB; EP300; ACTN3; FYNB; ACTB1; IGF1RA; WASF3
Chagas disease (American trypanosomiasis)
SERPINE1; MAP2K4; GNA15; PLCB2; GNAL; TICAM1; C1QA; CD247; C1QB; PIK3R1
Hepatitis B
PRKCG; STAT1; CYCS; NFKBIA; MAP2K4; IRF3; MYD88; NFKB1; AKT1; EP300
HTLV-I infection
TGFB2; SPI1; RRAS; VDAC2; SFPI1; RAN; MSX2; XIAP; PPP3CC; PIK3R2
Pathways in cancer
WNT8B; RXRA; FGF12; FGF4; PTCH2; LAMA3; HSP90AB1; LAMA4; GNG11; RARA
Colorectal cancer
PIK3R5; SMAD4; TGFB1; CYCS; GSK3B; PIK3R1; MAPK8; TP53; PIK3CB; ARAF
Pancreatic cancer
PIK3CA; ARHGEF6; RALGDS; SMAD2; PIK3R2; BAD; STAT1; PIK3CB; RAD51; IKBKG
Chronic myeloid leukemia
CBL; KRAS; CTBP2; PIK3R3; TP53; NRAS; MDM2; PIK3R2; RB1; PTPN11

Protein Function

TGFBR1 has several biochemical functions, for example, ATP binding, I-SMAD binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR1 itself. We selected most functions TGFBR1 had, and list some proteins which have the same functions with TGFBR1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KIF5B; CSNK2A2; DGKB; PRPF4BA; ATP13A3; CKMT1; PRKCBA; SARS; KATNAL1; AGK
Function I-SMAD binding
Related Protein SMAD1; TGFBR1; AXIN2; SMAD6; AXIN1; CTNNB1; SMAD7; SMURF1; SMAD2; SMAD4
Function SMAD binding
Related Protein SKI; AXIN1; ACVR1B; PML; PRDM16; BMPR1A; DAB2; CREBBP; SNW1; TGFBRAP1
Function contributes_to growth factor binding
Related Protein TGFBR1; ACVR1B; ERBB2; IL6ST
Function metal ion binding
Related Protein ZNF215; AGBL1; GNA15; KCNH7; ZFP11; FHL2B; ZNF750; HENMT1; HNRNPA0L; ITGA2B
Function protein binding
Related Protein ROBO1; ARHGEF6; ZMYM2; MATN3; TXNRD1; C1orf50; STRAP; SSNA1; BICC1; MAP4K3
Function protein kinase activity
Related Protein KITB; FASTKD5; RIPK1L; NAT1; BRAF; MAP4K1; DAPK2A; GM711; PAN3; TGFBR1B
Function protein serine/threonine kinase activity
Related Protein ARAF; CAMK2D; NUAK2; PAK2B; MAPK13; STK32C; PAK3; NEK11; CDC42BPB; PAK7
Function receptor signaling protein activity
Related Protein CD3E; KLK1B3; RAF1B; RAF1A; PLCG1; FLRT3; PLCE1; TYROBP; cgr2b; IFITM1
Function receptor signaling protein serine/threonine kinase activity
Related Protein TGFBR1A; ACVRL1; STK24A; ACVR1BA; SBK3; BMPR2B; ALPK2; BMPR1BB; PAK2A; STK25B
Function transforming growth factor beta binding
Related Protein TGFB3; LTBP4; ACVR1; HYAL2; THBS1; CD109; TGFBR3; ITGAV; ENG; TGFBR2
Function contributes_to transforming growth factor beta binding
Related Protein TGFBR3; TGFBR2; ENG; TGFBR1
Function transforming growth factor beta receptor activity, type I
Related Protein BMPR1B; TGFBR1; ACVR1
Function transforming growth factor beta-activated receptor activity
Related Protein LTBP1; TGFBR1; BMPR2A; TGFBR3; ACVRL1; BMPR2B; TGFBR2; ENG
Function contributes_to transforming growth factor beta-activated receptor activity
Related Protein TGFBR1
Function type II transforming growth factor beta receptor binding
Related Protein ENG; TGFB1; TGFBR1; TGFB3; TGFB1A; BAMBI; TGFB2; TGFBR3

Interacting Protein

TGFBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR1.
q99ib8-pro_0000045599; TGFB3; FKBP1A; YWHAZ; TGFB1; Rnf5

TGFBR1 Related Gene Family

TGF