tlr5
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  • Official Full Name
  • toll-like receptor 5
  • Background
  • This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
  • Synonyms
  • TLR5; toll-like receptor 5; TIL3; SLEB1; FLJ10052; MGC126430; MGC126431; OTTHUMP00000036039; OTTHUMP00000036040; toll/interleukin-1 receptor-like protein 3; TLR 5; TLR5_HUMAN; Toll/interleukin 1 receptor like protein 3; TIL 3; Toll like receptor 5 precursor
Cat.#:TLR5-2075HTag:His|S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR5 protein, His & S-tagged
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Cat.#:TLR5-2076HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR5 protein, His-tagged
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Cat.#:TLR5-30142THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TLR5
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Cat.#:TLR5-392HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TLR5 protein, Fc-tagged
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Cat.#:TLR5-902HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TLR5 protein, MYC/DDK-tagged
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Cat.#:TLR5-903HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR5 protein, His-tagged
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Cat.#:TLR5-989HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR5 protein, GST-tagged
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Cat.#:Tlr5-2077MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tlr5 protein, His & GST-tagged
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Cat.#:Tlr5-392MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Tlr5 protein, Fc-tagged
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Cat.#:Tlr5-2078RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tlr5 protein, His & GST-tagged
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Cat.#:TLR5-4734RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TLR5 Protein, His-tagged
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Cat.#:TLR5-2190CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TLR5
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Cat.#:TLR5-1045HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TLR5 293 Cell Lysate
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Involved Pathway

TLR5 involved in several pathways and played different roles in them. We selected most pathways TLR5 participated on our site, such as Toll-like receptor signaling pathway, Pathogenic Escherichia coli infection, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Toll-like receptor signaling pathway
CCL3; IL8L1; RIPK1; MAPK14A; IFNA12; CD40; IFNA16; IRAK4; CD80; MAPK3
Pathogenic Escherichia coli infection
ARHGEF2; TUBB6; NCK1; ITGB1; TUBB1; TUBB2B; WAS; PRKCA; TUBAL3; TUBA4A
Salmonella infection
CCL3L3; CXCL2; DYNC1I2A; RHOGB; WASLA; MAPK8B; RAC1B; KLC2; IFNG; IL1A
Legionellosis
CASP9; IL1B; ITGAM; SEC22B; HSPA2; BNIP3; CYCS; SAR1B; NFKB1; ITGB2
Inflammatory bowel disease (IBD)
HLA-DRB4; RELA; IL2RG; MAF; STAT3; HLA-DMA; Il4ra; RORC; STAT1; GATA3

Protein Function

TLR5 has several biochemical functions, for example, interleukin-1 receptor binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR5 itself. We selected most functions TLR5 had, and list some proteins which have the same functions with TLR5. You can find most of the proteins on our site.
Function
Related Protein
Function interleukin-1 receptor binding
Related Protein IL1F10; TLR5; IRAK1; IL36A; TRIP6; IL1A; IL1B; IL36G; TLR9; IL1RAP
Function transmembrane signaling receptor activity
Related Protein ICAM1; DCC; GP6; TLR18; MPL; BAI2; FCAMR; CLEC4A; TNFRSF11A; GPR126

Interacting Protein

TLR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR5.
PAUF; MYD88

TLR5 Related Articles

Nishi, H; Maeda, N; et al. Differential regulation of epidermal growth factor receptor by hydrogen peroxide and flagellin in cultured lung alveolar epithelial cells. EUROPEAN JOURNAL OF PHARMACOLOGY 748:133-142(2015).
Lockner, JW; Eubanks, LM; et al. Flagellin as Carrier and Adjuvant in Cocaine Vaccine Development. MOLECULAR PHARMACEUTICS 12:653-662(2015).