TLR5
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Official Full Name
toll-like receptor 5
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Overview
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease. -
Synonyms
TLR5; toll-like receptor 5; TIL3; SLEB1; FLJ10052; MGC126430; MGC126431; OTTHUMP00000036039; OTTHUMP00000036040; toll/interleukin-1 receptor-like protein 3; TLR 5; TLR5_HUMAN; Toll/interleukin 1 receptor like protein 3; TIL 3; Toll like receptor 5 precursor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- CHO
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Fc
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|S
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- TLR5 Related Articles
- TLR5 Related Research Area
TLR5 involved in several pathways and played different roles in them. We selected most pathways TLR5 participated on our site, such as Toll-like receptor signaling pathway, Pathogenic Escherichia coli infection, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Toll-like receptor signaling pathway | IFNB;IFNPHI1;TLR3;IFNA5;IFNB1;PIK3R2;CCL4;IRF5;MYD88 |
Pathogenic Escherichia coli infection | TUBA1A;NCL;TUBB2A;TUBB;ITGB1;TUBAL3;HCLS1;CDC42;CTTN |
Salmonella infection | KLC2;CCL3L3;FOS;LBP;FLNC;RAC1B;FLNB;WASLA;DYNC1LI2 |
Legionellosis | TLR4;RAB1A;CASP8;NFKB1;CXCL3;HSF1;APAF1;IL12B;IL18 |
Inflammatory bowel disease (IBD) | HLA-DMA;IL2RG;HLA-DRB4;RORC;TLR2;HLA-DRB3;TGFB1;H2-AA;FOXP3 |
TLR5 has several biochemical functions, for example, interleukin-1 receptor binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR5 itself. We selected most functions TLR5 had, and list some proteins which have the same functions with TLR5. You can find most of the proteins on our site.
Function | Related Protein |
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interleukin-1 receptor binding | TLR5;IL1RAP;IL1RN;IL36A;IL1B;IL36G;IRAK1;IL36RN;IL1A |
transmembrane signaling receptor activity | OR4N4;GPR133;CLDN4;P2RX6;SORL1;TNFRSF10D;HIST2H3C2;IL4R.1;KLRB1 |
TLR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR5.
PAUF; MYD88
- Q&As
- Reviews
Q&As (7)
Ask a questionTLR5 helps regulate gut microbiota composition, maintaining intestinal health and preventing dysbiosis.
TLR5 plays a crucial role in protecting against gut bacterial infections by recognizing flagellin and initiating immune defense.
Dysfunctional TLR5 can contribute to inflammatory bowel diseases, affecting gut inflammation and immune responses.
TLR5 modulates inflammation, influencing cytokine production and the body's response to infection.
TLR5 detects bacterial flagellin, triggering signaling pathways that activate immune responses against infections.
Variations in TLR5 function can alter susceptibility to gastrointestinal infections and related disorders.
TLR5 is involved in developing systemic immunity, enhancing the body's overall defense against pathogens.
Customer Reviews (3)
Write a reviewOutstanding protein-protein interaction studies, vital for our experiments.
Accurate protein structural analysis, a cornerstone of our investigations.
High-quality protein characterization, fundamental for our research.
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