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TLR5

  • Official Full Name

    toll-like receptor 5

  • Overview

    This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
  • Synonyms

    TLR5; toll-like receptor 5; TIL3; SLEB1; FLJ10052; MGC126430; MGC126431; OTTHUMP00000036039; OTTHUMP00000036040; toll/interleukin-1 receptor-like protein 3; TLR 5; TLR5_HUMAN; Toll/interleukin 1 receptor like protein 3; TIL 3; Toll like receptor 5 precursor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Fc
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLR5-2038H Active Recombinant Human TLR5 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human TLR5-30142TH Recombinant Human TLR5 Wheat Germ N/A 118 amino acids
Human TLR5-902H Recombinant Human TLR5 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TLR5-392H Recombinant Human TLR5 protein, Fc-tagged CHO Fc
Human TLR5-989H Recombinant Human TLR5 protein, GST-tagged E.coli GST
Human TLR5-2076H Recombinant Human TLR5 protein, His-tagged E.coli His Leu303~Leu514 (Accession # O60602)
Human TLR5-903H Recombinant Human TLR5 protein, His-tagged E.coli His
Human TLR5-2075H Recombinant Human TLR5 protein, His & S-tagged E.coli His/S Asn46~Ala205 (Accession # O60602)
Human TLR5-1045HCL Recombinant Human TLR5 293 Cell Lysate HEK293 N/A
Human TLR5-6701HFL Recombinant Full Length Human TLR5 protein, Flag-tagged Mamanlian cells Flag
Human TLR5-2954H Recombinant Human TLR5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TLR5-6464H Recombinant Human TLR5 Protein (Ile21-Phe115), N-His tagged E.coli N-His Ile21-Phe115
Mouse Tlr5-392M Active Recombinant Mouse Tlr5 protein, Fc-tagged CHO Fc
Mouse Tlr5-2077M Recombinant Mouse Tlr5 protein, His & GST-tagged E.coli His/GST Lys327~Glu646 (Accession # Q9JLF7)
Mouse Tlr5-6454M Recombinant Mouse Tlr5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Tlr5-2078R Recombinant Rat Tlr5 protein, His & GST-tagged E.coli His/GST Asp325~Glu644 (Accession # G3V6F8)
Rhesus Macaque TLR5-4734R Recombinant Rhesus monkey TLR5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TLR5-4548R Recombinant Rhesus Macaque TLR5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TLR5-4548R-B Recombinant Rhesus Macaque TLR5 Protein Pre-coupled Magnetic Beads HEK293
Chicken TLR5-2190C Recombinant Chicken TLR5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TLR5 Related Articles
  • TLR5 Related Research Area

TLR5 involved in several pathways and played different roles in them. We selected most pathways TLR5 participated on our site, such as Toll-like receptor signaling pathway, Pathogenic Escherichia coli infection, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Toll-like receptor signaling pathwayTLR7;MAP2K4;AKT2;TNF;MAPK11;MAP2K1;PIK3R1;MAPK13;IFNB1
Pathogenic Escherichia coli infectionEZR;TUBA1B;ARPC5L;TUBA3D;LY96;NCK2;CDH1;TUBA8;TUBAL3
Salmonella infectionFLNC;KLC1B;TLR4;KLC1;CD14;CXCL8B.3;NOS2A;RAC1B;IFNGR2
LegionellosisTLR4;IL1B;HSPA1L;ITGAM;HSPA1B;CASP9;NAIP7;HSPA8;RAB1B
Inflammatory bowel disease (IBD)NFKB1;IL21R;RORA;HLA-DQA1;IL12A;IFNG;HLA-DRB4;IL4R;IL13

TLR5 has several biochemical functions, for example, interleukin-1 receptor binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR5 itself. We selected most functions TLR5 had, and list some proteins which have the same functions with TLR5. You can find most of the proteins on our site.

Function Related Protein
interleukin-1 receptor bindingIL1F10;IL36G;IL36B;IL1RN;Il1f6;IRAK1;TLR5;TLR9;IL36A
transmembrane signaling receptor activitySPN;CELSR1;LAG3;CD97;TLR3;PTH1RA;GHRHR2;CLDN4;KLRC1

TLR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR5.

PAUF; MYD88

Nishi, H; Maeda, N; et al. Differential regulation of epidermal growth factor receptor by hydrogen peroxide and flagellin in cultured lung alveolar epithelial cells. EUROPEAN JOURNAL OF PHARMACOLOGY 748:133-142(2015).
Lockner, JW; Eubanks, LM; et al. Flagellin as Carrier and Adjuvant in Cocaine Vaccine Development. MOLECULAR PHARMACEUTICS 12:653-662(2015).
  • Q&As
  • Reviews

Q&As (7)

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How does TLR5 contribute to the modulation of gut microbiota and intestinal homeostasis? 10/19/2021

TLR5 helps regulate gut microbiota composition, maintaining intestinal health and preventing dysbiosis.

What role does TLR5 play in the defense against bacterial infections, particularly in the gut? 03/03/2021

TLR5 plays a crucial role in protecting against gut bacterial infections by recognizing flagellin and initiating immune defense.

What is the impact of TLR5 dysfunction on inflammatory bowel diseases like Crohn's disease and ulcerative colitis? 02/27/2021

Dysfunctional TLR5 can contribute to inflammatory bowel diseases, affecting gut inflammation and immune responses.

What are the mechanisms by which TLR5 modulates the inflammatory response and cytokine production? 08/08/2020

TLR5 modulates inflammation, influencing cytokine production and the body's response to infection.

How does TLR5 (Toll-Like Receptor 5) recognize bacterial flagellin and initiate immune responses? 06/20/2020

TLR5 detects bacterial flagellin, triggering signaling pathways that activate immune responses against infections.

How do alterations in TLR5 expression or function affect susceptibility to gastrointestinal infections and disorders? 11/15/2019

Variations in TLR5 function can alter susceptibility to gastrointestinal infections and related disorders.

How does TLR5 influence the development of systemic immunity following exposure to pathogens? 01/24/2019

TLR5 is involved in developing systemic immunity, enhancing the body's overall defense against pathogens.

Customer Reviews (3)

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Reviews
07/29/2022

    Outstanding protein-protein interaction studies, vital for our experiments.

    07/24/2019

      Accurate protein structural analysis, a cornerstone of our investigations.

      02/02/2018

        High-quality protein characterization, fundamental for our research.

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