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Recombinant Human TLR5 protein, Fc-tagged

Cat.No. : TLR5-392H
Product Overview : Recombinant Human TLR5(aa 21-639) fused with Fc region of human IgG1 at N-terminal was expressed in CHO cells.
  • Specification
  • Gene Information
  • Related Products
Source : CHO
Species : Human
Tag : Fc
Form : 0.2 µm filtered solution in phosphate buffer with glycine, saccharose and stabilizing agents
Molecular Mass : Has an apparent molecular weight of 110 kDa on SDS-PAGE.
Applications : Neutralization, receptor binding assays
Storage : Store lyophilized product at -20 centigrade. Product is stable for at least 1 year.
Gene Name : TLR5 toll-like receptor 5 [ Homo sapiens ]
Official Symbol : TLR5
Synonyms : TLR5; toll-like receptor 5; FLJ10052; MGC126430; MGC126431; SLEB1; TIL3; Toll/interleukin 1 receptor like protein 3; toll/interleukin-1 receptor-like protein 3;
Gene ID : 7100
mRNA Refseq : NM_003268
Protein Refseq : NP_003259
MIM : 603031
UniProt ID : O60602
Chromosome Location : 1q32.3-q42
Pathway : Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Legionellosis, organism-specific biosystem; Legionellosis, conserved biosystem; MyD88 cascade initiated on plasma membrane, organism-specific biosystem; Pathogenic Escherichia coli infection, organism-specific biosystem; Pathogenic Escherichia coli infection, conserved biosystem;
Function : interleukin-1 receptor binding; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does TLR5 contribute to the modulation of gut microbiota and intestinal homeostasis? 10/19/2021

TLR5 helps regulate gut microbiota composition, maintaining intestinal health and preventing dysbiosis.

What role does TLR5 play in the defense against bacterial infections, particularly in the gut? 03/03/2021

TLR5 plays a crucial role in protecting against gut bacterial infections by recognizing flagellin and initiating immune defense.

What is the impact of TLR5 dysfunction on inflammatory bowel diseases like Crohn's disease and ulcerative colitis? 02/27/2021

Dysfunctional TLR5 can contribute to inflammatory bowel diseases, affecting gut inflammation and immune responses.

What are the mechanisms by which TLR5 modulates the inflammatory response and cytokine production? 08/08/2020

TLR5 modulates inflammation, influencing cytokine production and the body's response to infection.

How does TLR5 (Toll-Like Receptor 5) recognize bacterial flagellin and initiate immune responses? 06/20/2020

TLR5 detects bacterial flagellin, triggering signaling pathways that activate immune responses against infections.

How do alterations in TLR5 expression or function affect susceptibility to gastrointestinal infections and disorders? 11/15/2019

Variations in TLR5 function can alter susceptibility to gastrointestinal infections and related disorders.

How does TLR5 influence the development of systemic immunity following exposure to pathogens? 01/24/2019

TLR5 is involved in developing systemic immunity, enhancing the body's overall defense against pathogens.

Customer Reviews (3)

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Reviews
07/29/2022

    Outstanding protein-protein interaction studies, vital for our experiments.

    07/24/2019

      Accurate protein structural analysis, a cornerstone of our investigations.

      02/02/2018

        High-quality protein characterization, fundamental for our research.

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