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Official Full Name tumor necrosis factor, alpha-induced protein 3
Background NF-B (nuclear factor B) regulates the expression of a large number of genes that play critical roles in apoptosis, viral replication, tumorigenesis, various autoimmune diseases and inflammation. The zinc finger protein A20 is a tumor necrosis factor and interleukin 1 (IL-1)-inducible protein that negatively regulates NF-B gene expression by interferring with a novel TNF-induced and RIP-or TRAF2-mediated pathway that is different from the NIK-IB kinase pathway. A20, an 70 kDa protein, is expressed at low levels in most organs, the highest expression levels being in lymphoid tissues.
Synonyms TNFAIP3; tumor necrosis factor, alpha-induced protein 3; tumor necrosis factor alpha-induced protein 3; A20; OTUD7C; TNFAIP3 (A20); zinc finger protein A20; TNF alpha-induced protein 3; OTU domain-containing protein 7C; putative DNA-binding protein A20; tumor necrosis factor inducible protein A20; TNFA1P2; MGC104522; MGC138687; MGC138688
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Tnfaip3-6542M Recombinant Mouse Tnfaip3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human TNFAIP3-156H Recombinant Human TNFAIP3, GST-tagged E.coli GST
    Human TNFAIP3-159H Recombinant Human TNFAIP3 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TNFAIP3-2154H Recombinant Human TNFAIP3 Protein, GST-tagged Wheat Germ GST
    Human TNFAIP3-2156H Recombinant Human TNFAIP3 Protein, GST-tagged Wheat Germ GST
    Human TNFAIP3-567H Recombinant Human TNFAIP3 Protein, His-tagged E.coli His
    Cynomolgus Monkey TNFAIP3-1039C Recombinant Cynomolgus TNFAIP3 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque TNFAIP3-4862R Recombinant Rhesus monkey TNFAIP3 Protein, His-tagged Mammalian Cell His

    TNFAIP3 involved in several pathways and played different roles in them. We selected most pathways TNFAIP3 participated on our site, such as NF-kappa B signaling pathway, NOD-like receptor signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFAIP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway TRAF1; TNFRSF11A; PLCG1; ZAP70; BIRC2; MYD88; NFKB2; RELA; PIDD1; TRIM25
    NOD-like receptor signaling pathway CXCL1; NFKB1; NFKBIAA; BIRC2; RIPK2; MAPK12A; MAPK12; RELA; NFKBIB; IL-8
    TNF signaling pathway CXCL1; RIPK1; PIK3CG; RPS6KA5; TRAF2; MAP3K14; TNFRSF1A; MMP14; IL15; CFLAR
    Epstein-Barr virus infection POLR1C; POLR2J; HSPB2; PRKACB; PSMD7; H2-Q10; PSMC4; TRAF1; NEDD4; POLR2A

    TNFAIP3 has several biochemical functions, for example, DNA binding, K63-linked polyubiquitin binding, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFAIP3 itself. We selected most functions TNFAIP3 had, and list some proteins which have the same functions with TNFAIP3. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding PHOX2BB; GTF2E2; HOXC8A; PCBP4; RX3; H2AFX; BAZ2B; DDIT3; SP100; ZNF445
    K63-linked polyubiquitin binding SPRTN; TNFAIP3; SQSTM1; OTUD7B; ZRANB3; PRPF8; UIMC1; TAB2; ZRANB1B; ATRIP
    kinase binding MIDN; PARK2; UBQLN1; SP100; TRADD; CHP; PFKFB1; CEBPA; ABI2; GFAP
    ligase activity HUWE1; TRAF2; ZNRF2B; RNF13; HECW1; UBE2KB; MEX3C; TRIM11; RTCB; NEDD4L
    protease binding TRIP4; SERPINA1; Cstb; TIMP1; SERPINE1; CRADD; TIMP4; NDUFS7; UBC; SERPINA1A
    protein binding KLHL2; MORF4L1; SMARCB1; FYCO1; HCST; FAM154A; KLK13; CDC27; BLVRA; ZNF490
    protein self-association VAMP2; CTSC; SLC2A1; S100A7A; SYP; AGTR1B; RYR2; SHANK3; CNTN2; AXIN1
    ubiquitin binding MARK4; KCNS1; FAM125A; D17WSU92E; UCHL1; OTUB1A; UBXN2B; UBAP1; RNF31; OTUB2
    ubiquitin-protein transferase activity ZNF738; SMURF1; BIRC2; FBXO2; MYLIP; HECW1B; TOPORS; HECTD1; CBLL1; UBE2D2
    ubiquitin-specific protease activity USP43A; USP28; OTUD5A; USP8; USP4; OTUD4; USP31; USP10; COPS5; USP40
    zinc ion binding TRIM42; CHURC1; POLR3K; SOD1; RNF112; TGFB1I1; TET1; MMP14B; MYT1; USP13

    TNFAIP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFAIP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFAIP3.


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