Recombinant Full Length Human TNFAIP3 Protein, C-Flag-tagged

• Cat.No.: TNFAIP3-1013HFL
• Product Overview: Recombinant Full Length Human TNFAIP3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 89.4 kDa
• AA Sequence: MAEQVLPQALYLSNMRKAVKIRERT PEDIFKPTNGIIHHFKTMHRYTLEM FRTCQFCPQFREIIHKALID RNIQATLESQKKLNWCREVRKLVAL KTNGDGNCLMHATSQYMWGVQDTDL VLRKALFSTLKETDTRNFKF RWQLESLKSQEFVETGLCYDTRNWN DEWDNLIKMASTDTPMARSGLQYNS LEEIHIFVLCNILRRPIIVI SDKMLRSLESGSNFAPLKVGGIYLP LHWPAQECYRYPIVLGYDSHHFVPL VTLKDSGPEIRAVPLVNRDR GRFEDLKVHFLTDPENEMKEKLLKE YLMVIEIPVQGWDHGTTHLINAAKL DEANLPKEINLVDDYFELVQ HEYKKWQENSEQGRREGHAQNPMEP SVPQLSLMDVKCETPNCPFFMSVNT QPLCHECSERRQKNQNKLPK LNSKPGPEGLPGMALGASRGEAYEP LAWNPEESTGGPHSAPPTAPSPFLF SETTAMKCRSPGCPFTLNVQ HNGFCERCHNARQLHASHAPDHTRH LDPGKCQACLQDVTRTFNGICSTCF KRTTAEASSSLSTSLPPSCH QRSKSDPSRLVRSPSPHSCHRAGND APAGCLSQAARTPGDRTGTSKCRKA GCVYFGTPENKGFCTLCFIE YRENKHFAAASGKVSPTASRFQNTI PCLGRECGTLGSTMFEGYCQKCFIE AQNQRFHEAKRTEEQLRSSQ RRDVPRTTQSTSRPKCARASCKNIL ACRSEELCMECQHPNQRMGPGAHRG EPAPEDPPKQRCRAPACDHF
  GNAKCNGYCNECFQFKQMYGTRTRP LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: NOD-like receptor signaling pathway

Gene Information

• Gene Name: TNFAIP3 TNF alpha induced protein 3 [ Homo sapiens (human) ]
• Official Symbol: TNFAIP3
• Synonyms: A20; AISBL; AIFBL1; OTUD7C; TNFA1P2
• Gene ID: 7128
• mRNA Refseq: NM_006290.4
• Protein Refseq: NP_006281.1
• MIM: 191163
• UniProt ID: P21580