tnfrsf11a
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  • Official Full Name
  • tumor necrosis factor receptor superfamily, member 11a
  • Background
  • Murine sRANK-Ligand or Soluble Receptor Activator of NF-κB Ligand, also known as Tumor Necrosis Factor Ligand Superfamily Member 11, is a 316 amino acid cytokine protein expressed from the Tnfsf11 gene located on chromosome 14. The peptide chain that exists from residue 1-36 is the membrane form of the RANK-Ligand while the chain that exists from residue 139-178 is the soluble form of the RANK-Ligand. The soluble form of isoform 1 derives from the membrane form by proteolytic processing. The cleavage may be catalyzed by ADAM17. The sRANK-Ligand is the cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK and acts as an osteoclast differentiation and activation factor. Moreover, the sRANK-Ligand homotrimer augments the ability of dendritic cells to stimulate naive T- cell proliferation, and thus may be an important regulator of interactions between T-cells and dendritic cells as well as T- cell-dependent immune responses. It is highly expressed in thymus and lymph nodes, but not in non-lymphoid tissues and is abundantly expressed in T-cells but not in B-cells; a high level expression is also seen in the trabecular bone and lung. Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.
  • Synonyms
  • Ly109; ODFR; OFE; Rank; TRANCE-R; mRANK; osteoclast differentiation factor receptor; receptor activator of NF-KB; receptor activator of NF-kappaB; tumor necrosis factor receptor superfamily member 11A
Cat.#:TNFRSF11A-392HTag:MIgG2a Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF11A Protein, MIgG2a Fc-tagged, low endotoxin
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Cat.#:TNFRSF11A-184HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF11A Protein, His-tagged
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Cat.#:TNFRSF11A-1997HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF11A Protein
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Cat.#:Tnfrsf11a-185MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf11a Protein, His-tagged
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Cat.#:Tnfrsf11a-186RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tnfrsf11a Protein, His-tagged
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Cat.#:TNFRSF11A-1678HTag:FC/His
Source (Host):NS0Species:Human
Product nameRecombinant Human TNFRSF11A, Fc-His
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Cat.#:TNFRSF11A-30901THTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF11A, Fc-tagged
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Cat.#:TNFRSF11A-400HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF11A, Fc-tagged
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Cat.#:TNFRSF11A-401HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF11A, His-tagged
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Cat.#:TNFRSF11A-40HTag:HIgG/His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human TNFRSF11A Protein, hIgG-His-tagged
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Cat.#:TNFRSF11A-663HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TNFRSF11A, Fc-tagged, Biotinylated
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Cat.#:TNFRSF11A-17152MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TNFRSF11A Protein
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Cat.#:Tnfrsf11a-1775MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Tnfrsf11a
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Cat.#:Tnfrsf11a-472MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfrsf11a, Fc-tagged
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Cat.#:Tnfrsf11a-955MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf11a Protein, Fc Chimera
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Cat.#:TNFRSF11A-1084RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TNFRSF11A Protein, Fc-tagged
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Cat.#:TNFRSF11A-1085RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TNFRSF11A Protein, His-tagged
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Cat.#:TNFRSF11A-1642RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFRSF11A Protein
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Cat.#:TNFRSF11A-1643RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFRSF11A Protein, hIgG1-tagged
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Cat.#:TNFRSF11A-1644RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFRSF11A Protein, hIgG4-tagged
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Cat.#:TNFRSF11A-591HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF11A
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Cat.#:TNFRSF11A-1413RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TNFRSF11A cell lysate
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Involved Pathway

TNFRSF11A involved in several pathways and played different roles in them. We selected most pathways TNFRSF11A participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL20RB; Ifna11; TNF; BMPR2A; TSLP; ACVR1B; CCL27; IFNAR1; CCL13; CSF1RA
NF-kappa B signaling pathway
LBP; IRAK4; TLR4; LTBR; BCL2L1; ATM; PLCG1; BLNK; BCL2A1A; BIRC2
Osteoclast differentiation
NOX3; PPP3CB; PIK3R3; LCP2; SOCS3; LILRA2; PPP3CC; FYN; IL1A; NCF2
Prolactin signaling pathway
SHC4; PIK3CB; RAF1; IRF1; FOS; TH; NFKB1; CCND2; TNFRSF11A; KRAS
Rheumatoid arthritis
HLA-DRB4; HLA-DMB; ATP6V0C; IL1A; IL-8; CXCL5; IFNG; TLR4; TNFSF13; ATP6V0E2

Protein Function

TNFRSF11A has several biochemical functions, for example, cytokine binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF11A itself. We selected most functions TNFRSF11A had, and list some proteins which have the same functions with TNFRSF11A. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine binding
Related Protein ELANE; CRLF1; CNTFR; CHRD; KITB; KIT; CSF1R; KITA; PARK7; IL17F
Function metal ion binding
Related Protein TMEM129; RASAL1; TGFBR2; VAV3; ZDHHC21; ZNF613; GNA15; CYP17A2; S100T; ZFP580
Function protein binding
Related Protein KISS1; NUDT10; PDE9A; LDLRAD1; SERPINI2; WLS; MERTK; HIST1H2BF; CRYAA; WBP2
Function receptor activity
Related Protein CUBN; TNFRSF17; PVRL1A; TNPO3; TLR4; Siglece; KRT1; VMN1R54; ITGB8; VMN1R46
Function transmembrane signaling receptor activity
Related Protein SORL1; OR4F29; GP6; FZD1; TNFRSF8; SEMA4D; CD300C; CLEC1B; IL11RA; FZD8A
Function tumor necrosis factor-activated receptor activity
Related Protein TNFRSF19; TNFRSF4; TNFRSF11A; Tnfrsf26; CD27; TNFRSF21; TNFRSF9A; EDA2R; TNFRSF10C; NGFRB

Interacting Protein

TNFRSF11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF11A here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF11A.
TMPRSS15; TRAF5; TRAF2; TRAF6

TNFRSF11A Related Gene Family

TNF Cytokines