tnfrsf14
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  • Official Full Name
  • tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
  • Background
  • TNFRSF14, also known as HVEM (herpes virus entry mediator), TR2 (TNF receptor like molecule) and ATAR (another TRAF-associated receptor), is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.
  • Synonyms
  • TNFRSF14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); TR2; ATAR; HVEA; HVEM; LIGHTR; CD40-like protein; OTTHUMP00000000866; OTTHUMP00000204095; OTTHUMP00000204096; OTTHUMP00000204097; herpesvirus entry mediator A; herpes virus entry mediator A; tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2; CD270
Cat.#:TNFRSF14-1996HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF14 Protein, MYC/DDK-tagged
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Cat.#:TNFRSF14-1691HTag:FC/His
Source (Host):NS0Species:Human
Product nameRecombinant Human TNFRSF14, Fc-His
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Cat.#:TNFRSF14-2443HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human TNFRSF14, His-tagged
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Cat.#:TNFRSF14-30480THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human TNFRSF14, Fc-tagged
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Cat.#:TNFRSF14-5144HTag:N/A
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry Mediator)
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Cat.#:TNFRSF14-555HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF14, His tagged
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Cat.#:TNFRSF14-613HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TNFRSF14
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Cat.#:TNFRSF14-624HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TNFRSF14, Fc-tagged, Biotinylated
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Cat.#:TNFRSF14-625HTag:Fc/Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF14 Protein, Fc & Avi-tagged, Biotinylated
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Cat.#:TNFRSF14-756HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF14, Fc-His tagged
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Cat.#:TNFRSF14-877HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human TNFRSF14 Protein, DDK/His-tagged
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Cat.#:TNFRSF14-878HTag:Fc
Source (Host):Hi-5 Insect cellsSpecies:Human
Product nameRecombinant Human TNFRSF14 Protein, Fc-tagged
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Cat.#:TNFRSF14-945HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TNFRSF14, Fc Chimera
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Cat.#:Tnfrsf14-1062MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf14 protein, His-tagged
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Cat.#:Tnfrsf14-428MTag:FC/His
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf14, His-Fc tagged
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Cat.#:Tnfrsf14-757MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfrsf14, Fc-His tagged
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Cat.#:Tnfrsf14-869MTag:Fc
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf14 Protein, Fc Chimera
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Cat.#:TNFRSF14-75CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFRSF14, Fc tagged
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Cat.#:TNFRSF14-4868RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TNFRSF14 Protein, His-tagged
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Cat.#:TNFRSF14-2155HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF14 cell lysate
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Cat.#:TNFRSF14-001MCLTag:
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse TNFRSF14 cell lysate
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Cat.#:TNFRSF14-2420MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TNFRSF14 cell lysate
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Cat.#:TNFRSF14-1133CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFRSF14 cell lysate
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Involved Pathway

TNFRSF14 involved in several pathways and played different roles in them. We selected most pathways TNFRSF14 participated on our site, such as Cytokine-cytokine receptor interaction, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF14 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TGFB1A; Kitl; TNFRSF1B; CCL15; CXCL6; GM13304; BMPR1AA; TNFSF14; CCL20; IL11
Herpes simplex infection
SRSF9; EP300; OAS1A; BMA1; PPP1CAB; HLA-DRB1; MAPK8B; IKBKG; PER1B; TBP

Protein Function

TNFRSF14 has several biochemical functions, for example, protein binding, tumor necrosis factor-activated receptor activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF14 itself. We selected most functions TNFRSF14 had, and list some proteins which have the same functions with TNFRSF14. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein CEP170L; GALNT2; VPS54; FOXO4; BAIAP2L1; TAF12; AZIN1; ZNF274; IL6; SPARC
Function tumor necrosis factor-activated receptor activity
Related Protein TNFRSF1A; CD40; TNFRSF8; LTBR; TNFRSFA; TNFRSF1B; Tnfrsf26; RELT; NGFR; FAS
Function ubiquitin protein ligase binding
Related Protein MC4R; CUL5; XRCC5; UBE2J2; SLC25A5; ACTG1; YWHAE; TCP1; POLR2A; TXNIP
Function virus receptor activity
Related Protein GPR172B; TYRO3; HSPA1A; IDE; ITGB7; CD46; HLA-DRB1; ITGAV; CCR5; TNFRSF14

Interacting Protein

TNFRSF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF14.
TRAF5; TRAF2; TNFSF14; TRAF2; gD; q65zq1_human; PER2

TNFRSF14 Related Articles

del Rio, ML; Fernandez-Renedo, C; et al. Therapeutic Blockade of LIGHT Interaction With Herpesvirus Entry Mediator and Lymphotoxin beta Receptor Attenuates In Vivo Cytotoxic Allogeneic Responses. TRANSPLANTATION 98:1165-1174(2014).
Herraez, DL; Martinez-Bueno, M; et al. Rheumatoid Arthritis in Latin Americans Enriched for Amerindian Ancestry is Associated With Loci in Chromosomes 1, 12, and 13, and the HLA Class II Region. ARTHRITIS AND RHEUMATISM 65:1457-1467(2013).

TNFRSF14 Related Gene Family

TNF Cytokines