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TNFSF14

  • Official Full Name

    tumor necrosis factor (ligand) superfamily, member 14

  • Overview

    The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
  • Synonyms

    TNFSF14; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand superfamily member 14; CD258; HVEM L; LIGHT; LTg; delta transmembrane LIGHT; herpesvirus entry mediator A; herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; herpes virus entry mediator ligand; ligand for herpesvirus entry mediator; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT; TR2; HVEML;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rhesus monkey
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Human Cells
  • Insect cell
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Myc
  • DDK
  • Fc
  • Flag
  • hFc
  • His (Fc)
  • Avi
  • His|S
  • human|IgG1|Fc
  • Mouse|IgG2a|Fc
  • N/A
  • N
  • rFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFSF14-970H Active Recombinant Human TNFSF14 Mammalian cells N/A
Human TNFSF14-4603H Active Recombinant Human TNFSF14 protein, hFc-Myc-tagged Mammalian cell hFc-Myc 74-240aa
Human TNFSF14-1324H Acitve Recombinant Human TNFSF14 protein(Asp74-Val240), rFc-tagged HEK293 N-rFc Asp74-Val240
Human TNFSF14-392H Recombinant Human TNFSF14, FLAG-tagged CHO Flag
Human TNFSF14-217H Recombinant Human TNFSF14 protein, His-tagged HEK293 His Asp74-Val240
Human TNFSF14-29950TH Recombinant Human TNFSF14 N/A
Human TNFSF14-7782H Recombinant Human TNFSF14 protein, His & S-tagged E.coli His/S His62~Val240 (Accession# O43557)
Human TNFSF14-354H Recombinant Human Tumor Necrosis Factor (ligand) Superfamily, Member 14 Human N/A
Human TNFSF14-29946TH Recombinant Human TNFSF14, FLAG-tagged CHO Flag 152 amino acids
Human TNFSF14-891HCL Recombinant Human TNFSF14 293 Cell Lysate HEK293 N/A
Human TNFSF14-1326H Recombinant Human TNFSF14 Protein (Tyr69-Asp317), N-His tagged E.coli N-His Tyr69-Asp317
Human TNFSF14-552H Recombinant Human TNFSF14 protein, Fc-tagged HEK293 human/IgG1/Fc Asp74-Val240
Human TNFSF14-207H Recombinant Human TNFSF14 protein, His-tagged HEK293 His It contains Asp74-Val240.
Human TNFSF14-552HAF488 Recombinant Human TNFSF14 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc Asp74-Val240
Human TNFSF14-5236H Recombinant Human TNFSF14 Protein (Leu59-Val240), N-His tagged Mammalian cells N-His Leu59-Val240
Human TNFSF14-394H Recombinant Human TNFSF14 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc 167
Human TNFSF14-217HAF555 Recombinant Human TNFSF14 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Asp74-Val240
Human TNFSF14-4501H Recombinant Human TNFSF14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNFSF14-217HAF488 Recombinant Human TNFSF14 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Asp74-Val240
Human TNFSF14-144H Recombinant Human TNFSF14 protein, His-Flag-tagged HEK293 His-Flag It contains Asp74-Val240 Trimer Design.
Human TNFSF14-552HAF555 Recombinant Human TNFSF14 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc Asp74-Val240
Human TNFSF14-288H Recombinant Human TNFSF14 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human TNFSF14-150H Recombinant Human TNFSF14 Protein, His-tagged E.coli His
Human TNFSF14-4501H-B Recombinant Human TNFSF14 Protein Pre-coupled Magnetic Beads HEK293
Human TNFSF14-217HAF647 Recombinant Human TNFSF14 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Asp74-Val240
Human TNFSF14-0342H Active Recombinant Human TNFSF14 protein, Fc-tagged HEK293 Fc Asp74-Val240
Human TNFSF14-552HAF647 Recombinant Human TNFSF14 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc Asp74-Val240
Human TNFSF14-5237H Recombinant Human TNFSF14 Protein (Leu83-Val240), N-His tagged Mammalian cells N-His Leu83-Val240
Human TNFSF14-217HF Recombinant Human TNFSF14 Protein, His-tagged, FITC conjugated HEK293 His Asp74-Val240
Human TNFSF14-303H Active Recombinant Human TNFSF14 Protein (Arg64-Val240), C-His tagged, Animal-free, Carrier-free E.coli C-His Arg64-Val240
Human TNFSF14-552HF Recombinant Human TNFSF14 Protein, hFc-tagged, FITC conjugated HEK293 hFc Asp74-Val240
Human TNFSF14-151H Recombinant Human TNFSF14 Protein, His-tagged Human Cells His
Human TNFSF14-86H Recombinant Human TNFSF14 Protein, His-tagged Human Cell His
Human TNFSF14-1178H Recombinant Human TNFSF14 Protein (Asp74-Val240), N-His tagged E.coli N-His Asp74-Val240
Mouse Tnfsf14-948M Recombinant Mouse Tnfsf14 E.coli N/A
Mouse TNFSF14-17176M Recombinant Mouse TNFSF14 Protein Mammalian Cell His
Mouse Tnfsf14-7783M Recombinant Mouse Tnfsf14 protein, His & S-tagged E.coli His/S Thr51~Val239 (Accession # Q9QYH9)
Mouse TNFSF14-2020M Recombinant Mouse TNFSF14 protein E.coli N/A 168
Mouse TNFSF14-1544M Recombinant Mouse TNFSF14 Protein, His-tagged Insect cell His
Mouse TNFSF14-9484M-B Recombinant Mouse TNFSF14 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tnfsf14-6555M Recombinant Mouse Tnfsf14 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tnfsf14-243M Active Recombinant Mouse Tnfsf14 Protein (Arg58-Val239), C-His tagged, Animal-free, Carrier-free E.coli C-His Arg58-Val239
Mouse Tnfsf14-147M Recombinant Mouse Tnfsf14 Protein E.coli
Mouse TNFSF14-9484M Recombinant Mouse TNFSF14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tnfsf14-6750M Recombinant Mouse Tnfsf14 Protein (Asp72-Val239), N-His tagged Mammalian cells N-His Asp72-Val239
Rat Tnfsf14-7784R Recombinant Rat Tnfsf14 protein, His-tagged E.coli His Arg58~Ile239 (Accession # M0RCN2)
Rhesus monkey TNFSF14-1636R Recombinant Rhesus Monkey TNFSF14 Protein HEK293 N/A
Cynomolgus Monkey TNFSF14-1040C Recombinant Cynomolgus TNFSF14 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey TNFSF14-783C Recombinant Cynomolgus Monkey TNFSF14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey TNFSF14-783C-B Recombinant Cynomolgus Monkey TNFSF14 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL23757HF Recombinant Full Length Human Tumor Necrosis Factor Ligand Superfamily Member 14(Tnfsf14) Protein, His-Tagged E.coli expression system His Full Length (1-240)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TNFSF14 Related Articles
  • TNFSF14 Related Gene Family
  • TNFSF14 Related Signal Pathway

TNFSF14 involved in several pathways and played different roles in them. We selected most pathways TNFSF14 participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCCR6A;BMPR1AA;IL17RB;IL5;IL10RA;TNFSF9;IL22RA1;IL1RAP;XCL2
NF-kappa B signaling pathwayTNF;PLAU;CD14;Ccl21c;ZAP70;CCL21;CD40;TNFRSF13C;LRDD
Herpes simplex infectionHCFC1;CFP;SRSF5;OAS1B;CUL1A;IFNG1-2;HLA-G;SFRS9;TAP1

TNFSF14 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF14 itself. We selected most functions TNFSF14 had, and list some proteins which have the same functions with TNFSF14. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase inhibitor activity involved in apoptotic processIGF1RB;NOL3;SERPINB1A;BIRC2;RPS6KA1;LEF1;BIRC7;DPEP1;SNCA
cytokine activityIL36G;CMTM2B;IL36RN;ADIPOQ;CSF1A;Flt3l;IL24;CMTM8;BMP4
protein bindingRGR;TERF1;RELL2;NR4A2;LAPTM4B;TAF2;SLC4A1A;RCC1;RINT1
receptor bindingItga10&Itgb1;MSTN;DPP4;CADM2A;GNPAT;PVRL2L;BAAT;C3;PTK2
tumor necrosis factor receptor bindingTRAF3;TNFSF11;ERAP1;TNFSF10L3;TNFSF9;TNF;CD40LG;TRAF4;TRAP1

TNFSF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF14.

TNFRSF14; TNFRSF6B; LTB

del Rio, ML; Fernandez-Renedo, C; et al. Therapeutic Blockade of LIGHT Interaction With Herpesvirus Entry Mediator and Lymphotoxin beta Receptor Attenuates In Vivo Cytotoxic Allogeneic Responses. TRANSPLANTATION 98:1165-1174(2014).
Kojima, R; Kajikawa, M; et al. Molecular Basis for Herpesvirus Entry Mediator Recognition by the Human Immune Inhibitory Receptor CD160 and Its Relationship to the Cosignaling Molecules BTLA and LIGHT. JOURNAL OF MOLECULAR BIOLOGY 413:762-772(2011).
TNF
  • Q&As
  • Reviews

Q&As (7)

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What are the primary changes induced by TNFSF14 in the tumor microenvironment? 05/19/2022

TNFSF14, when delivered to or expressed within tumors, causes significant changes primarily through vascular normalization and generation of tertiary lymphoid structures.

What challenges remain in utilizing TNFSF14 for cancer immunotherapy? 07/02/2021

While investigators have used multiple vectors to deliver TNFSF14 to tumor tissues, there are still improvements needed, and components within the human tumor microenvironment may impede translational efforts.

What does TNFSF14 stand for? 02/05/2021

TNFSF14 stands for Tumor Necrosis Factor Superfamily Member 14.

How can TNFSF14 synergize with other immunotherapy modalities? 02/22/2020

TNFSF14's changes in the tumor microenvironment can synergize with methods inducing anti-tumor immune responses, such as checkpoint inhibitors and tumor vaccines, improving immunotherapeutic strategies against cancer.

In what context has TNFSF14 been utilized to combat cancer? 02/06/2018

TNFSF14 has been used in multiple tumor models, where it can be combined with other immunotherapy modalities to clear established solid tumors and treat metastatic events.

How long has TNFSF14 been in pre-clinical development? 06/11/2017

TNFSF14 has been in pre-clinical development for over a decade.

What is the primary promise of TNFSF14 in the field of cancer immunotherapy? 08/15/2016

TNFSF14 shows promise in enhancing treatment approaches in cancer immunotherapy.

Customer Reviews (3)

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Reviews
07/28/2020

    The extended longevity of results gave us the confidence to delve deeper into complex biological processes.

    08/01/2018

      It was reassuring to know that the product's effects persisted, allowing for thorough and comprehensive research.

      06/19/2016

        The ability to obtain enduring results positively influenced the depth of our investigations.

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