tnfsf14
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  • Official Full Name
  • tumor necrosis factor (ligand) superfamily, member 14
  • Background
  • The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
  • Synonyms
  • TNFSF14; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand superfamily member 14; CD258; HVEM L; LIGHT; LTg; delta transmembrane LIGHT; herpesvirus entry mediator A; herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; herpes virus entry mediator ligand; ligand for herpesvirus entry mediator; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT; TR2; HVEML
Cat.#:TNFSF14-1544MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse TNFSF14 Protein, His-tagged
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Cat.#:TNFSF14-394HTag:MIgG2a Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF14 Protein, MIgG2a Fc-tagged, low endotoxin
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Cat.#:TNFSF14-552HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF14 Protein, Fc-tagged
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Cat.#:TNFSF14-2020MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse TNFSF14 Protein
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Cat.#:TNFSF14-217HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF14 Protein, His-tagged
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Cat.#:TNFSF14-29946THTag:Flag
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TNFSF14, FLAG-tagged
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Cat.#:TNFSF14-29950THTag:
Source (Host):Species:Human
Product nameRecombinant Human TNFSF14
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Cat.#:TNFSF14-392HTag:Flag
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TNFSF14, FLAG-tagged
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Cat.#:TNFSF14-7782HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF14 protein, His & S-tagged
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Cat.#:TNFSF14-970HTag:
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human TNFSF14
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Cat.#:TNFSF14-17176MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TNFSF14 Protein
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Cat.#:Tnfsf14-7783MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfsf14 protein, His & S-tagged
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Cat.#:Tnfsf14-948MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfsf14
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Cat.#:Tnfsf14-7784RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tnfsf14 protein, His-tagged
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Cat.#:TNFSF14-1040CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFSF14 Protein, His-tagged
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Cat.#:TNFSF14-1636RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFSF14 Protein
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Cat.#:TNFSF14-354HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor (ligand) Superfamily, Member 14
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Cat.#:TNFSF14-891HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TNFSF14 293 Cell Lysate
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Involved Pathway

TNFSF14 involved in several pathways and played different roles in them. We selected most pathways TNFSF14 participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IFNA6; TGFB1; CCL23; LEPR; LTA; CCL13; IL13; IL12B; ACVR2B; CCR5
NF-kappa B signaling pathway
XIAP; BTK; TNFSF14; GADD45B; CXCL12; RIPK1; PTGS2; IKBKB; Ccl21c; NFKB1
Herpes simplex infection
IFNA1; OAS3; FAS; DDX58; IFNA10; C3A.3; NFKBIA; SRSF7; HLA-DMA; EEF1D

Protein Function

TNFSF14 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF14 itself. We selected most functions TNFSF14 had, and list some proteins which have the same functions with TNFSF14. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein ARRB1; SERPINB1A; C1QL4L; TFAP2B; BIRC2; TNFAIP8; XIAP; BIRC8; LEF1; SNCA
Function cytokine activity
Related Protein VEGFA; TNFSF12; TNFSF15; ILTIFB; GDF3; RNF207B; IFNA2; CMTM2B; IL13; MSTNB
Function protein binding
Related Protein TBX3; NCKIPSD; PTGES3; CHMP4A; FCGR2B; EIF4A1; RAB1; DPYSL5; RAVER2; RTN3
Function receptor binding
Related Protein AMACR; H2-Q10; Ifnl2; SRMS; ANKRD13C; NUDT19; FGF6B; MIF; EPB49; IL28A
Function tumor necrosis factor receptor binding
Related Protein TNFSF11; TNFSF10L4; CD70; TNFSF15; TNFSF4; Fasl; TNFSF8; TNFSF13B; LTA; LTB

Interacting Protein

TNFSF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF14.
TNFRSF14; TNFRSF6B; LTB

TNFSF14 Related Articles

del Rio, ML; Fernandez-Renedo, C; et al. Therapeutic Blockade of LIGHT Interaction With Herpesvirus Entry Mediator and Lymphotoxin beta Receptor Attenuates In Vivo Cytotoxic Allogeneic Responses. TRANSPLANTATION 98:1165-1174(2014).
Kojima, R; Kajikawa, M; et al. Molecular Basis for Herpesvirus Entry Mediator Recognition by the Human Immune Inhibitory Receptor CD160 and Its Relationship to the Cosignaling Molecules BTLA and LIGHT. JOURNAL OF MOLECULAR BIOLOGY 413:762-772(2011).

TNFSF14 Related Gene Family

TNF