TNFSF14
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Official Full Name
tumor necrosis factor (ligand) superfamily, member 14
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Overview
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. -
Synonyms
TNFSF14; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand superfamily member 14; CD258; HVEM L; LIGHT; LTg; delta transmembrane LIGHT; herpesvirus entry mediator A; herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; herpes virus entry mediator ligand; ligand for herpesvirus entry mediator; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT; TR2; HVEML;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rhesus monkey
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human
- Human Cell
- Human Cells
- Insect cell
- Mammalian cell
- Mammalian Cell
- Mammalian cells
- C
- His
- Myc
- DDK
- Fc
- Flag
- hFc
- His (Fc)
- Avi
- His|S
- human|IgG1|Fc
- Mouse|IgG2a|Fc
- N/A
- N
- rFc
- Involved Pathway
- Protein Function
- Interacting Protein
- TNFSF14 Related Articles
- TNFSF14 Related Gene Family
- TNFSF14 Related Signal Pathway
TNFSF14 involved in several pathways and played different roles in them. We selected most pathways TNFSF14 participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | TNFRSF10D;CCL20B;FLT4;TNFRSF19;CD27;CCL3L1;CCR9A;IL8L1;CCL27B |
NF-kappa B signaling pathway | LYN;ICAM1;IRAK1;CCL13;VCAM1;CFLAR;TRAF6;LAT;TNF |
Herpes simplex infection | CUL1A;SRSF7A;PER1;PPP1CAB;TBP;TAF10;FASLG;NXF1;HLA-DQA2 |
TNFSF14 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF14 itself. We selected most functions TNFSF14 had, and list some proteins which have the same functions with TNFSF14. You can find most of the proteins on our site.
Function | Related Protein |
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cysteine-type endopeptidase inhibitor activity involved in apoptotic process | XIAP;DPEP1;BIRC8;GAS6;VIL1;IGF1RB;PRDX3;TNFAIP8;SERPINB1A |
cytokine activity | GREM1;INHBC;GDF6B;TNFSF12;IL22;TGFB2;IL17F;PRL7D1;Il1f6 |
protein binding | HSPA4L;PRKD3;NFKBIL2;NCF2;MTPAP;C1QTNF9B-AS1;TECPR1;COPRS;TGFB2 |
receptor binding | ARPP19;SLC9A3R1;PIPOX;INSL4;FZD1;FGG;LTB;DVL3;KNG1 |
tumor necrosis factor receptor binding | TRADD;TNFSF11;TRAF4;TNF;TNFSF10L;TNFSF8;TNFSF10L3;TRAF3;TNFSF9 |
TNFSF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF14.
TNFRSF14; TNFRSF6B; LTB
- Q&As
- Reviews
Q&As (7)
Ask a questionTNFSF14, when delivered to or expressed within tumors, causes significant changes primarily through vascular normalization and generation of tertiary lymphoid structures.
While investigators have used multiple vectors to deliver TNFSF14 to tumor tissues, there are still improvements needed, and components within the human tumor microenvironment may impede translational efforts.
TNFSF14 stands for Tumor Necrosis Factor Superfamily Member 14.
TNFSF14's changes in the tumor microenvironment can synergize with methods inducing anti-tumor immune responses, such as checkpoint inhibitors and tumor vaccines, improving immunotherapeutic strategies against cancer.
TNFSF14 has been used in multiple tumor models, where it can be combined with other immunotherapy modalities to clear established solid tumors and treat metastatic events.
TNFSF14 has been in pre-clinical development for over a decade.
TNFSF14 shows promise in enhancing treatment approaches in cancer immunotherapy.
Customer Reviews (3)
Write a reviewThe extended longevity of results gave us the confidence to delve deeper into complex biological processes.
It was reassuring to know that the product's effects persisted, allowing for thorough and comprehensive research.
The ability to obtain enduring results positively influenced the depth of our investigations.
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