zbtb16
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  • Official Full Name
  • zinc finger and BTB domain containing 16
  • Background
  • This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.
  • Synonyms
  • ZBTB16; zinc finger and BTB domain containing 16; zinc finger protein 145 (Kruppel like, expressed in promyelocytic leukemia) , ZNF145; zinc finger and BTB domain-containing protein 16; PLZF; zinc finger protein PLZF; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia); ZNF145
Cat.#:ZBTB16-5253RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ZBTB16 Protein, His-tagged
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Cat.#:ZBTB16-741HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ZBTB16 lysate
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Involved Pathway

ZBTB16 involved in several pathways and played different roles in them. We selected most pathways ZBTB16 participated on our site, such as Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZBTB16 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pathways in cancer
ROCK1; TGFB1; MET; LAMA4; BIRC5; WNT9B; RXRG; TGFA; RXRB; VEGFA
Transcriptional misregulation in cancer
RUNX1T1; ARNT2; GZMB; HIST2H3A; ZBTB17; SPI1; KLF3; MET; IGF1; HIST1H3C
Acute myeloid leukemia
KRAS; AKT1; CCNA1; SOS1; RELA; JUP; PIK3CG; PIK3CA; PIM2; PIK3R5

Protein Function

ZBTB16 has several biochemical functions, for example, DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZBTB16 itself. We selected most functions ZBTB16 had, and list some proteins which have the same functions with ZBTB16. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein GSX1; RARGA; HIST1H4J; RAD51C; MYO18A; NKX1.2LA; CDKN2A; SIX6; IRF2A; ESR2B
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein MSC; NR5A2; NR2F6; CDX2; H2AFZ; ATF2; POU4F1; T; SOX10; GATA2
Function identical protein binding
Related Protein LUC7L; MRI1; UBQLN4; AKT1; VWF; VPS41; GSTM3; LEPR; FXR2; DAAM1
Function metal ion binding
Related Protein GRIN2A; KCNH7; CYB561D2; KLK1B4; ZNHIT2; KSR1; MICALL2A; RHOU; ZFP668; ASNA1
Function protein C-terminus binding
Related Protein ATF4; SIRT1; SCLT1; CAV3; VTA1; MED12; TBL1X; LCK; AP2A1; PEX16
Function protein binding
Related Protein GPR128; KRTAP3-1; RTDR1; DPM2; SULT1A2; MGAT5B; C4BPA; CPSF2; CISD2; MKNK2
Function protein domain specific binding
Related Protein Ar; HGS; EFS; CNOT1; DDX20; MED12; YWHAH; UNC13A; VRK2; LIN7C
Function protein homodimerization activity
Related Protein KIAA1804; SRM; IKZF4; PDGFC; VEGFB; PVR; TSG101; FLT3LG; XCL1; ATP2A1
Function transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein BACH1; ZBTB16; ARX; PROP1; PAX4; BACH2; MSC; GZF1

Interacting Protein

ZBTB16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZBTB16 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZBTB16.
PML; EEF1A1; IL6; Hoxa1; TRAF2

ZBTB16 Related Articles

Zheng, Y; Thomas, A; et al. Quantitative detection of human spermatogonia for optimization of spermatogonial stem cell culture. HUMAN REPRODUCTION 29:2497-2511(2014).
Pomerantz, RG; Mirvish, ED; et al. Novel approach to gene expression profiling in Sezary syndrome. BRITISH JOURNAL OF DERMATOLOGY 163:1090-1094(2010).