Native Mouse Alpha-2-Macroglobulin

• Cat.No.: A2m-367M
• Product Overview: Native Mouse A2m isprepared from Mouse Serum.

Specification

• Cat. No.: A2m-367M
• Description: A2mis a serum protease inhibitor that consists of two major polypeptides withmolecular weights of approximately 163 kDa and 35 kDa together with a minorpolypeptide of 185 kDa. A2m is able to inactivate an enormous variety ofproteinases (including serine-, cysteine-, aspartic-, andmetalloproteinases). A2m uses a bait region to bind proteinases. Theproteinase- A2m complex is recognized by macrophage receptors and clearedfrom the system. A2m function as an inhibitor of coagulation by inhibitingthrombin. A2m also functions as an inhibitor of fibrinolysis by inhibitingplasmin and kallikrein.
• Form: 150 mM NaCl+10 mMSodium Phosphate pH 7.2
• Source: Mouse Serum
• Purity: > 90% by SDS-PAGE
• Concentration: Typically>0.5mg/mL
• Storage: Store ≤ -20°C.
• Pathways: Complement and Coagulation Cascades
• Tag: Non

Gene Information

• Gene Name: A2m alpha-2-macroglobulin [ Musmusculus ]
• Official Symbol: A2m
• Synonyms: A2m;alpha-2-macroglobulin; A2mp; alpha-2-macroglobulin-P
• Gene ID: 232345
• mRNA Refseq: NM_175628
• Protein Refseq: NP_783327
• MIM: Q6GQT1
• Chromosome Location: 6
• Function: endopeptidaseinhibitor activity; enzyme binding; growth factor binding; interleukin-1binding; peptidase inhibitor activity; serine-type endopeptidase inhibitoractivity; tumor necrosis factor binding

Reviews

04/19/2022

It can be seen that the production process of A2M pays great attention to purity and biological activity, which makes its products have extremely high application value.

05/23/2020

Short half-life and high clearance of A2M make them more suitable for use in emergency medical situations and provide more treatment options for patients.

03/09/2020

The production process of A2M achieves efficient use of energy, reduces energy consumption, reduces carbon emissions, and is very environmentally friendly.

Q&As

What role does A2M protein play in the immune system?

It play an important role in the immune system, binding and neutralizing viruses, bacteria, reducing inflammation, and participating in immune regulation.

What is the relationship between A2M protein and lung disease?

Studies of the A2M protein in lung disease have shown that it may work by inhibiting inflammation and reducing lung tissue damage.

In which organs or tissues are A2M proteins expressed high?

The expression of A2M protein in organs or tissues such as liver, kidney, and lymphoid tissue is high.

How does A2M protein remove harmful proteins from the body?

Proteins eventually clear harmful proteins by capturing and binding to harmful proteins and then entering the cell through internalization.

Can A2M protein be used as a potential therapeutic target for cardiovascular disease?

A2M proteins show potential therapeutic targets in cardiovascular diseases and may have effects on cardiovascular diseases by modulating inflammatory responses and blood clotting.

In which neurological diseases are A2M proteins studied?

A2M proteins are studied in many neurological diseases, such as Parkinson's disease, stroke, etc., and may be involved in processes such as inflammation and oxidative stress.