| Description : |
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
N-His |
| Form : |
Lyophilized powder |
| Molecular Mass : |
Recombinant human A2M protein has a calculated molecular mass of 160 kDa. For unknown reason, the purified A2M protein can not enter SDS-PAGE gel. The identity of purified A2M protein was confirmed by Sandwich ELISA using specific antibodies. |
| Protein Length : |
Ser24-Ala1474 |
| Purity : |
> 95% |
| Storage : |
Upon arrival, the lyophilized protein may be stored for 2 weeks at 4 centigrade. For long term storage, it is recommended to store desiccated below -20 centigrade in a manual defrost freezer. Following reconstitution, the protein may be stored for 2 weeks under sterile conditions at -20 centigrade. For long term storage, it is recommended to make appropriate aliquots and store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : |
Lyophilized from a 0.2 μm filtered solution in PBS (pH 7.4) |
| Reconstitution : |
Briefly spin the vial and bring the contents to the bottom prior to opening. It is recommended to reconstitute at 0.5-1.0 mg/mL with sterile deionized water. |
| Shipping : |
Ice packs |
