| Species : |
Human |
| Source : |
HEK293 |
| Tag : |
His |
| Description : |
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. |
| Form : |
Lyophilized from a 0.2 µm filtered solution in PBS (pH 7.4). |
| Molecular Mass : |
160 kDa |
| Endotoxin : |
<0.5 EU per µg of the protein as determined by the LAL method. |
| Purity : |
>95% as determined by SDS-PAGE under reducing conditions and visualized by Coomassie blue staining. |
| Usage : |
This product is furnished for LABORATORY RESEARCH USE ONLY. Not for diagnostic or therapeutic use. |
| Storage : |
Upon arrival, the protein may be stored for 2 weeks at 4 centigrade. For long term storage, it is recommended to store at -20 centigrade or -80 centigrade in appropriate aliquots. Avoid repeated freeze-thaw cycles. |
| Concentration : |
Determined by BCA protein assay. |
| Reconstitution : |
Briefly spin the vial and bring the contents to the bottom prior to opening. It is recommended to reconstitute at 0.5 - 1.0 mg/mL with sterile deionized water. |
| Shipping : |
Ice packs |
