Recombinant Mouse A2m Protein, His-tagged

• Cat.No.: A2m-02M
• Product Overview: Recombinant Mouse A2m Protein (Ser1022-Ala1495) with N-His tag was expressed in E. coli.

Specification

• Description: Predicted to enable several functions, including cytokine binding activity; growth factor binding activity; and serine-type endopeptidase inhibitor activity. Acts upstream of or within stem cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; embryo mesenchyme; liver; meninges; and retina. Human ortholog(s) of this gene implicated in COVID-19; background diabetic retinopathy; multiple sclerosis; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin).
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 56.1 kDa
  Accurate Molecular Mass: 56 kDa
• Protein length: Ser1022-Ala1495
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1 mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: A2m alpha-2-macroglobulin [ Mus musculus (house mouse) ]
• Official Symbol: A2m
• Synonyms: A2M; alpha-2-macroglobulin; alpha-2-macroglobulin-P; A2mp
• Gene ID: 232345
• mRNA Refseq: NM_175628
• Protein Refseq: NP_783327
• UniProt ID: Q6GQT1

Reviews

04/19/2022

It can be seen that the production process of A2M pays great attention to purity and biological activity, which makes its products have extremely high application value.

05/23/2020

Short half-life and high clearance of A2M make them more suitable for use in emergency medical situations and provide more treatment options for patients.

03/09/2020

The production process of A2M achieves efficient use of energy, reduces energy consumption, reduces carbon emissions, and is very environmentally friendly.

Q&As

What role does A2M protein play in the immune system?

It play an important role in the immune system, binding and neutralizing viruses, bacteria, reducing inflammation, and participating in immune regulation.

What is the relationship between A2M protein and lung disease?

Studies of the A2M protein in lung disease have shown that it may work by inhibiting inflammation and reducing lung tissue damage.

In which organs or tissues are A2M proteins expressed high?

The expression of A2M protein in organs or tissues such as liver, kidney, and lymphoid tissue is high.

How does A2M protein remove harmful proteins from the body?

Proteins eventually clear harmful proteins by capturing and binding to harmful proteins and then entering the cell through internalization.

Can A2M protein be used as a potential therapeutic target for cardiovascular disease?

A2M proteins show potential therapeutic targets in cardiovascular diseases and may have effects on cardiovascular diseases by modulating inflammatory responses and blood clotting.

In which neurological diseases are A2M proteins studied?

A2M proteins are studied in many neurological diseases, such as Parkinson's disease, stroke, etc., and may be involved in processes such as inflammation and oxidative stress.