ALPP
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Official Full Name
ALPP alkaline phosphatase, placental
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Synonyms
ALPP; alkaline phosphatase, placental; alkaline phosphatase, placental (Regan isozyme); alkaline phosphatase, placental type; Regan isozyme; PLAP-1; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme; ALP; PALP; PLAP; FLJ61142;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Cynomolgus
- Homo sapiens (Human)
- Human
- Rat
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Placenta
- In Vitro Cell Free System
- Insect Cell
- Mammalian cells
- Mouse
- Placental
- Rabbit
- Wheat Germ
- Yeast
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- ALPP Related Research Area
ALPP involved in several pathways and played different roles in them. We selected most pathways ALPP participated on our site, such as Folate biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALPP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Folate biosynthesis | ALPPL2;QDPRB1;QDPRB2;DHFR;FPGS;GCH2;QDPR;QDPRA;ALP3 |
Metabolic pathways | NDUFS3;INPP4A;CYP2S1;CKMT2;IDS;MECR;SPHK2;ALG1;HYAL6 |
ALPP has several biochemical functions, for example, alkaline phosphatase activity, magnesium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALPP itself. We selected most functions ALPP had, and list some proteins which have the same functions with ALPP. You can find most of the proteins on our site.
Function | Related Protein |
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alkaline phosphatase activity | ALP3;ALPI;ALPP;ALPL;ALPI.1;ALPPL2 |
magnesium ion binding | PGP;STK36;THTPA;ITPK1;CIB2;AASDHPPT;NT5C1AA;EPHX2;PKM2 |
protein binding | APBB2;DYRK1B;SCYL3;TSN;SLC14A2;TAF7L;GTF2I;MAP2K2;STOX1 |
zinc ion binding | NSD1;ZACN;ZNRD1;DPF2L;CA4B;MICALL2B;CA2;AGTPBP1;PAM |
ALPP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALPP here. Most of them are supplied by our site. Hope this information will be useful for your research of ALPP.
KRTAP5-9; KRTAP4-12; GPAA1; Cbx1; Erh; Cep76; Trim69; PIGK; A2M; SUMO3; SUMO1
- Q&As
- Reviews
Q&As (10)
Ask a questionALPP may serve as a diagnostic biomarker for specific diseases, allowing for disease detection and monitoring, and its targeting could hold therapeutic potential in certain pathological conditions.
ALPP participates in the metabolism and turnover of its substrate(s), including the hydrolysis of phosphoester bonds and the regulation of cellular phosphate homeostasis.
ALPP regulates downstream signaling pathways and molecular interactions involved in cellular processes like phosphate metabolism, intracellular signaling, and extracellular matrix remodeling.
ALPP gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in cellular homeostasis and disease processes.
ALPP is localized to specific cellular compartments, such as the plasma membrane, endoplasmic reticulum, or lysosomes, and its trafficking may be regulated by sorting signals and intracellular transport machinery.
ALPP activity can be modulated by factors such as pH, calcium, and inhibitors, which can affect its catalytic efficiency and cellular functions.
ALPP deficiency or dysregulation is associated with various diseases, including metabolic disorders, bone diseases, and certain cancers, highlighting its pathological implications.
Manipulating ALPP activity and function could offer strategies to modulate cellular processes and disease outcomes, potentially leading to therapeutic interventions and improved patient outcomes.
ALPP expression and activity exhibit dynamic changes during development, cellular differentiation, and disease progression, reflecting its roles in different physiological and pathological contexts.
ALPP shows a tissue-specific expression pattern, with higher levels in tissues such as liver, bone, and kidney, and lower levels in other organs.
Customer Reviews (3)
Write a reviewHigh-throughput screening compatibility.
Consistent protein expression analysis.
Precise protein quantification in ELISA.
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