Recombinant Human ALPP Protein, His tagged
Cat.No. : | ALPP-302H |
Product Overview : | Recombinant Human ALPP Protein with His tag was expressed in HEK293. |
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Description : | The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. |
Source : | HEK293 |
Species : | Human |
Tag : | C-His |
Form : | Lyophilized |
Molecular Mass : | The protein has a calculated MW of 53 kDa. |
AA Sequence : | IIPVEEENPDFWNREAAEALGAAKK LQPAQTAAKNLIIFLGDGMGVSTVT AARILKGQKKDKLGPEIPLAMDRFP YVALSKTYNVDKHVPDSGATATAYL CGVKGNFQTIGLSAAARFNQCNTTR GNEVISVMNRAKKAGKSVGVVTTTR VQHASPAGTYAHTVNRNWYSDADVP ASARQEGCQDIATQLISNMDIDVIL GGGRKYMFRMGTPDPEYPDDYSQGG TRLDGKNLVQEWLAKRQGARYVWNR TELMQASLDPSVTHLMGLFEPGDMK YEIHRDSTLDPSLMEMTEAALRLLS RNPRGFFLFVEGGRIDHGHHESRAY RALTETIMFDDAIERAGQLTSEEDT LSLVTADHSHVFSFGGYPLRGSSIF GLAPGKARDRKAYTVLLYGNGPGYV LKDGARPDVTESESGSPEYRQQSAV PLDEETHAGEDVAVFARGPQAHLVH GVQEQTFIAHVMAFAACLEPYTACD LAPPAGTTDVDHHHHHH |
Endotoxin : | < 0.01 EU/μg by LAL |
Purity : | > 95% by SDS-PAGE |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4, 10% trehalose |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.56 mg/mL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | ALPP alkaline phosphatase, placental [ Homo sapiens ] |
Official Symbol : | ALPP |
Synonyms : | ALPP; alkaline phosphatase, placental; alkaline phosphatase, placental (Regan isozyme); alkaline phosphatase, placental type; Regan isozyme; PLAP-1; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme; ALP; PALP; PLAP; FLJ61142; |
Gene ID : | 250 |
mRNA Refseq : | NM_001632 |
Protein Refseq : | NP_001623 |
MIM : | 171800 |
UniProt ID : | P05187 |
Products Types
◆ Recombinant Protein | ||
ALPP-329H | Recombinant Human ALPP Protein, His (Fc)-Avi-tagged | +Inquiry |
ALPP-125H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-124H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-495H | Recombinant Human ALPP Protein, GST-tagged | +Inquiry |
ALPP-67H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
ALPP-8347H | Native Human ALPP | +Inquiry |
ALPP-8005H | Native Human Placental Alkaline Phosphatase | +Inquiry |
◆ Lysates | ||
ALPP-8893HCL | Recombinant Human ALPP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALPP may serve as a diagnostic biomarker for specific diseases, allowing for disease detection and monitoring, and its targeting could hold therapeutic potential in certain pathological conditions.
ALPP participates in the metabolism and turnover of its substrate(s), including the hydrolysis of phosphoester bonds and the regulation of cellular phosphate homeostasis.
ALPP regulates downstream signaling pathways and molecular interactions involved in cellular processes like phosphate metabolism, intracellular signaling, and extracellular matrix remodeling.
ALPP gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in cellular homeostasis and disease processes.
ALPP is localized to specific cellular compartments, such as the plasma membrane, endoplasmic reticulum, or lysosomes, and its trafficking may be regulated by sorting signals and intracellular transport machinery.
ALPP activity can be modulated by factors such as pH, calcium, and inhibitors, which can affect its catalytic efficiency and cellular functions.
ALPP deficiency or dysregulation is associated with various diseases, including metabolic disorders, bone diseases, and certain cancers, highlighting its pathological implications.
Manipulating ALPP activity and function could offer strategies to modulate cellular processes and disease outcomes, potentially leading to therapeutic interventions and improved patient outcomes.
ALPP expression and activity exhibit dynamic changes during development, cellular differentiation, and disease progression, reflecting its roles in different physiological and pathological contexts.
ALPP shows a tissue-specific expression pattern, with higher levels in tissues such as liver, bone, and kidney, and lower levels in other organs.
Customer Reviews (3)
Write a reviewHigh-throughput screening compatibility.
Consistent protein expression analysis.
Precise protein quantification in ELISA.
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