Bace2

  • Official Full Name

    beta-site APP-cleaving enzyme 2

  • Overview

    This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimers disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  • Synonyms

    BACE2; beta-site APP-cleaving enzyme 2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; beta-secretase 2; memapsin-1; theta-secretase; aspartyl protease 1; 56 kDa aspartic-like protease; Down syndrome region aspartic protease; transmembrane aspartic proteinase Asp1; membrane-associated aspartic protease 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • HIS
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BACE2-579TH Active Recombinant Human BACE2, His-tagged Insect Cell HIS
Human BACE2-1831H Recombinant Human BACE2 protein, His-tagged E.coli His
Human BACE2-579H Recombinant Human BACE2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BACE2-10121H Recombinant Human BACE2, GST-tagged E.coli GST
Human BACE2-578TH Recombinant Human BACE2, GST-tagged Wheat Germ GST
Human BACE2-2688HFL Recombinant Full Length Human BACE2 protein, Flag-tagged Mamanlian cells Flag
Human BACE2-2540H Recombinant Human BACE2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Bace2-527M Active Recombinant Mouse Beta-Site APP-Cleaving Enzyme 2, His-tagged Mammalian cells His
Mouse Bace2-1832M Recombinant Mouse Bace2 protein, His & GST-tagged E.coli His/GST
Mouse BACE2-1388MCL Recombinant Mouse BACE2 cell lysate Human Cell N/A
Mouse Bace2-1816M Recombinant Mouse Bace2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Bace2-947M-B Recombinant Mouse Bace2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Bace2-947M Recombinant Mouse Bace2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse BACE2-33M Active Recombinant Mouse BACE2 Protein, His-Tagged HEK293 His
Mouse Bace2-11M Active Recombinant Mouse Bace2 Protein (20-462aa), C-His-tagged HEK293 C-His
Rat Bace2-1833R Recombinant Rat Bace2 protein, His & GST-tagged E.coli His/GST
Rat BACE2-930R Recombinant Rat BACE2 Protein Mammalian Cell His
Rat BACE2-588R Recombinant Rat BACE2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BACE2-588R-B Recombinant Rat BACE2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Bace2 Related Research Area

Bace2 involved in several pathways and played different roles in them. We selected most pathways Bace2 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with Bace2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alzheimers diseaseNDUFS6;NDUFA4;CALML5;NDUFS8;COX8C;NDUFS2;COX5B;SDHA;CALML3

Bace2 has several biochemical functions, for example, aspartic-type endopeptidase activity, beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Bace2 itself. We selected most functions Bace2 had, and list some proteins which have the same functions with Bace2. You can find most of the proteins on our site.

Function Related Protein
aspartic-type endopeptidase activityDDI2;SPPL3;Casp3;NRIP2;CTSE;BACE2;PSEN2;SPPL2;REN2
beta-amyloid bindingLDLRAD3;GPRASP2;Apba1;COL25A1;IDE;APOEB;ARMCX5-GPRASP2;MAPK8IP2;TM2D1

Bace2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Bace2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Bace2.

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