Recombinant Human BACE2, GST-tagged

• Cat.No.: BACE2-10121H
• Product Overview: Recombinant Human BACE2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 39-398a.a.
• Description: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimers disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the Down critical region of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: BACE2 beta-site APP-cleaving enzyme 2 [ Homo sapiens ]
• Official Symbol: BACE2
• Synonyms: BACE2; beta-site APP-cleaving enzyme 2; AEPLC; beta-secretase 2; ALP56; CEAP1; DRAP; asp 1; memapsin-1; theta-secretase; beta secretase 2; aspartyl protease 1; 56 kDa aspartic-like protease; aspartic-like protease 56 kDa; down region aspartic protease; beta-site APP cleaving enzyme 2; Down syndrome region aspartic protease; transmembrane aspartic proteinase Asp1; membrane-associated aspartic protease 1; beta-site amyloid precursor protein cleaving enzyme 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; ASP1; BAE2; ASP21; CDA13
• Gene ID: 25825
• mRNA Refseq: NM_012105
• Protein Refseq: NP_036237
• MIM: 605668
• UniProt ID: Q9Y5Z0
• Chromosome Location: 21q22.3
• Pathway: Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem
• Function: aspartic-type endopeptidase activity; peptidase activity