BECN1
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Official Full Name
beclin 1, autophagy related
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Overview
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration -
Synonyms
BECN1; beclin 1, autophagy related; ATG6; VPS30; beclin1; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); ATG6 autophagy related 6 homolog (S. cerevisiae); Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; Protein GT197; GT197; ATG6 autophagy related 6 homolog; ATG6; VPS30; beclin1; Bcl-2-interacting protein beclin;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|MBP
- His|SUMO
- Myc
- DDK
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- BECN1 Related Research Area
BECN1 involved in several pathways and played different roles in them. We selected most pathways BECN1 participated on our site, such as Regulation of autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with BECN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Regulation of autophagy | IFNA17;ATG4B;IFNA7;ATG14;ULK1;IFNA1;ATG5;BECN1;INS2 |
BECN1 has several biochemical functions, for example, phosphatidylinositol 3-kinase binding, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BECN1 itself. We selected most functions BECN1 had, and list some proteins which have the same functions with BECN1. You can find most of the proteins on our site.
Function | Related Protein |
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phosphatidylinositol 3-kinase binding | FYN;IGF1RB;INSRB;DAB1;PIK3R1;INSRA;INSR;LCK;IRS1 |
protein binding | SUN1;SORCS1;RPRD1B;KLRB1F;LIN7A;UBE2D3;WIBG;XAGE3;YIF1A |
ubiquitin protein ligase binding | RRAGA;YWHAZ;LRPPRC;BRCA1;CUL2;SNX9;DLG3;PARK2;SCAMP3 |
BECN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BECN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BECN1.
ATG14
- Q&As
- Reviews
Q&As (7)
Ask a questionBECN1 is involved in cancer, influencing both tumor suppression and survival.
It helps maintain cellular health by regulating the degradation and recycling of cellular components.
BECN1, a key autophagy protein, initiates the autophagic process, crucial for cellular waste disposal.
BECN1 interacts with a network of autophagy proteins, coordinating the autophagic response.
Altered BECN1 activity is linked to neurodegeneration, as autophagy is essential for neuronal health.
Targeting BECN1 could provide new treatments for cancer and neurodegenerative diseases by modulating autophagy.
Genetic mutations in BECN1 can lead to dysfunctional autophagy, affecting cell survival and health.
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